reachingforthestars Posted November 5, 2016 Share Posted November 5, 2016 Can some one help how to calculate how much SSRI accumulates or builds up after reaching steady dose? If the half life is 24 hours then for example the daily dose of 1mg builds up daily to 1.5mg, right? But what about those AD's that have longer half life like 32 hours or 3 days? Citalopram 40mg from 2003-2015 Jan 2015 started tapering first dropped to 35mg, Feb 30mg, March 25mg, April 20mg, May 17,5mg, June 15mg, July 12,5mg, Aug 12,5mg, Sep 0mg for 5 days because of stomac flu and after I raised to 7,5mg. All the symptoms of acute WD shaking, diarrhea, vomiting, barely could walk ect. Still didn't realize that it wasn't only stomac flu but I was also going through WD. Oct 2,5mg and crashed again badly and quickly raised to 4mg. It was then when I knew my symptoms were due to WD. Then in November after a month holding on 4mg raised to 5mg due to muscle weakness and had a VERY BAD reaction to reinstatement: akathisia(lasted for one or two weeks), insomnia, anhedonia... Drop quicly back to 4mg, Dec 3mg Jan 2016 2,6mg( in the middle of Jan after I had been on 2,6mg for a week I tried to updose to 2,8mg and immediately had bad reaction to it: akathisia for a day, andehonia got worse. The next day dropped back to 2,6mg), Feb 2,4mg( a new symptom PGAD lasted 24/7 for 2 months after that on and off), March 2,4mg, April 2,3mg, May 2,2mg, June 2,1mg, July 2,0mg( Pgad almost nonexisting, sleeping pretty good, still some anhedonia but there has been a lot of gradual progress), Aug 1,97mg-1,89mg, Sep 1,88mg-1,49mg, Oct 1,48mg- 1,70mg, Nov 0,65mg- current dose 0,5mg Link to comment Share on other sites More sharing options...
AliG Posted November 5, 2016 Share Posted November 5, 2016 RFTS. I'm not sure if I understand what you're getting at. Perhaps someone with a scientific bent could answer. I guess it builds more but what are you in doubt about ? I'm not sure if there is an answer to your question, but maybe we'll see. Many SSRI's and SSNRI's over 20 years. Zoloft for 7 years followed by Effexor, Lexapro, Prozac, Cymbalta, Celexa, Pristiq, Valdoxan, Mianserin and more - on and off. No tapering. Cold turkey off Valdoxan - end of May 2014 Psych Drug - free since May 2014 . Link to comment Share on other sites More sharing options...
Moderator Emeritus scallywag Posted November 5, 2016 Moderator Emeritus Share Posted November 5, 2016 It depends what you mean by build up. This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.1997-1999 Effexor; 2002-2005 Effexor XR 37.5 mg linear taper, dropping same #beads/week with bad results Cymbalta 60 mg 2012 - 2015; 2016: 20 mg to 7 mg exact doses and dates in this post; 2017: 6.3 mg to 0.0 mg Aug. 12; details here scallywag's IntroductionOnline spreadsheet for dose taper calculations and nz11's THE WORKS spreadsheet Link to comment Share on other sites More sharing options...
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