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Amanda23: in desperate need of advice


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I started Mirtazapine in March 2020 at 7.5mg. After a month or two I told my pcp about increased appetite and was told to take 15mg. In June I said it’s not giving me any benefits only side effects and was told to discontinue which made me very sick. I went back on after 1 week at 15mg. I did get relief after a few days but I’ve had bouts of depression I’ve never had, weird physical symptoms. I haven’t been the same since. About 2-3 weeks ago I started 15 every other day for about a week and a half then 7.5 every other for a few days now ive taken 7.5 the last three nights consecutively. I don’t know what to do and I really need help. I was prescribed this for panic attacks. Weird thing is each time I’ve either stopped or cut dosage my anxiety/panic have decreased since the first time CT in June. I have a weird dry skin type rash around my mouth, it’s not itchy at all though. The last 2 nights my sleep is a bit better but I’m exhausted all day. Should I just stop so my body can actually recover? I’m so lost and desperately need help. 

March 2020- started mirtazipine 7.5 for panic attacks 

April 2020- DR increased me to 15mg

June 2020- was told to completely discontinue

5 days later- horrible w/d, 2 days later reinstated at original dose

August 2020- decreased to 7.5

October 2020- following doctors advice I started an alternating taper schedule because I wanted to get off completely. I did it for 1-2 weeks before stopping altogether

2020-present- given 1mg Ativan PRN for severe panic attacks which I take infrequently. Since discontinuing mirtazipine they don't give me the same relief. Once I got worse, all other times it helped a nominal amount as compared to before where it would make it much much better

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  • ChessieCat changed the title to Amanda23: in desperate need of advice
  • Moderator Emeritus

Welcome to SA, Amanda23.


To give members the best information, we ask them to summarize their medication history in a signature -- drugs, doses, dates, and discontinuations & reinstatements, in the last 12-24 months particularly.


Account Settings – Create or Edit a signature.


As I understand it, your drug history is as follows:


March, 2020  Mirtazapine 7.5mg

April or May, 2020 Mirtazapine 15mg

June, 2020 CT Mirtazapine 15mg.  Reinstated 15mg after 1 week.

Approx. mid-August, 2020 began taking 15mg every other day for 1 1/2weeks, then 7.5 lor a few days

August 26, 2020 began taking 7.5 every day


If this is correct, please put this information in the link above and press "save."  If you've been on any other psychiatric medication, please include that in your signature, with doses and dates.


You are suffering from withdrawal from your cold turkey of 15mg in June, your skipping doses and changing doses.  You mentioned depression and "weird physical symptoms."  Please describe these physical symptoms.


What is withdrawal syndrome.


Daily Checklist of Antidepressant Withdrawal Symptoms (PDF) 


Right now you need to stabilize on a constant dose, taken every day.  Never dose every other day.  This makes the amount of the drug in your blood stream go up and down, battering your nervous system and making withdrawal worse.   I suggest you stay at 7.5mg until you feel stable.  I would not just stop.  

Your body has become dependent on the drug at this point, and a cold turkey cessation will make withdrawal worse.


After you have stabilized, you can taper slowly off the drug.  We recommend tapering by no more than 10% of your current dose every four weeks.


Why taper by 10% of my dosage?


This link is specifically about tapering Mirtazapine, including how to get the non-standard doses you'll need for your 10% taper when you're ready to start it.


Tips for tapering off mirtazapine (Remeron)


We don't recommend a lot of supplements on SA, as many members report being sensitive to them due to our over-reactive nervous systems, but two supplements that we do recommend are magnesium and omega 3 (fish oil). Many people find these to be calming to the nervous system. 


Magnesium, nature's calcium channel blocker 


Omega-3 fatty acids (fish oil) 


Add in one at a time and at a low dose in case you do experience problems.


This is your Introduction topic, where you can ask questions and connect with other members.  We're glad you found your way here.





Gridley Introduction


Lexapro 20 mg since 2004.  Begin Brassmonkey Slide Taper Jan. 2017.   

End 2017 year 1 of taper at 9.25mg 

End 2018 year 2 of taper at 4.1mg

End 2019 year 3 of taper at 1.0mg  

Oct. 30, 2020  Jump to zero from 0.025mg.  Current dose: 0.000mg

3 year, 10 month taper is 100% complete.


Ativan 1 mg to 1.875mg 1986-2020, two CT's and reinstatements

Nov. 2020, 7-week Ativan-Valium crossover to 18.75mg Valium

Feb. 2021, begin 10%/4 week taper of 18.75mg Valium 

End 2021  year 1 of Valium taper at 6mg

End 2022 year 2 of Valium taper at 2.75mg 

End 2023 year 3 of Valium taper at 1mg

Jan. 24, 2024: Hold at 1mg and shift to Imipramine taper.

Taper is 95% complete.


Imipramine 75 mg daily since 1986.  Jan.-Sept. 2016 tapered to 14.4mg  

March 22, 2022: Begin 10%/4 week taper

Aug. 5, 2022: hold at 9.5mg and shift to Valium taper

Jan. 24, 2024: Resume Imipramine taper.  Current dose as of May 2: 6.1mg

Taper is 92% complete.  


Supplements: multiple, quercetin, omega-3, vitamins C, E and D3, magnesium glycinate, probiotic, zinc, melatonin .3mg, iron, serrapeptase, nattokinase

I am not a medical professional and this is not medical advice but simply information based on my own experience, as well as other members who have survived these drugs.

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  • 5 months later...

Hi Amanda!

How is your problem with urination now? I have the same problems. I can’t sleep on abdomen because of pressure 

25 November 2020 - 22 December 2020 - Zoloft (3 weeks - 12.5 mg, 1 week - 25 mg); 1 January 2021 - Zoloft (12.5 mg)

18-24 December 2020 - Teraligen 2.5 mg-3.75 mg (Russian antipsychotic)

18-28 December 2020 - Eglonil 100 mg (Sulpiride)


Supplements: magnesium


Symptoms since stopping Zoloft: overactive/painful bladder, pelvic pressure, PGAD, severe anxiety




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