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I have chronic insomnia from histamine intolerance after tapering off Remerom 3 years ago. I also have Chronic Akathisia for 5 years from tapering off Chlonazapam. Drs. can’t help. I’m down to eating mostly meat since plant based food increases histamine.  I just stumble through my days still looking for answers. Right now I take tryptophan and Benedryl but it won’t help if I eat something wrong. I have taken anti depressants most of my life but can’t anymore. Weaned off of Cymbalta 6 years ago. Also took Vicodin for years. Now only take Propanolol for blood pressure. Just looking for support now. 

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  • ChessieCat changed the title to Oldlady123: intro
  • Moderator Emeritus

Welcome to SA, Oldlady123.  I'm sorry you're going through this. I think you'll find the members and moderators here helpful and supportive.


I know after all this time you've researched just about everything.  Some members have found relief with weighted blankets and bed tents.

Weighted blankets & bed tents for restlessness, akathisia ...

Here's a link on histamine food intolerance.  I hope it contains information that might be helpful to you.

Histamine food intolerance - Symptoms and self-care ...

It has been our experience here that withdrawal symptoms eventually do fade.  As you are experiencing, it can take a frustratingly long time.


We don't recommend a lot of supplements on SA, as many members report being sensitive to them due to our over-reactive nervous systems, but two supplements that we do recommend are magnesium and omega 3 (fish oil). Your diet issues might preclude your taking them, but many people find these to be calming to the nervous system. 


Magnesium, nature's calcium channel blocker 


Omega-3 fatty acids (fish oil) 


Add in one at a time and at a low dose in case you do experience problems.


This is your Introduction topic, where you can ask questions and connect with other members.  We're glad you found your way here.










Gridley Introduction


Lexapro 20 mg since 2004.  Begin Brassmonkey Slide Taper Jan. 2017.   

End 2017 year 1 of taper at 9.25mg 

End 2018 year 2 of taper at 4.1mg

End 2019 year 3 of taper at 1.0mg  

Oct. 30, 2020  Jump to zero from 0.025mg.  Current dose: 0.000mg

3 year, 10 month taper is 100% complete.


Ativan 1 mg to 1.875mg 1986-2020, two CT's and reinstatements

Nov. 2020, 7-week Ativan-Valium crossover to 18.75mg Valium

Feb. 2021, begin 10%/4 week taper of 18.75mg Valium 

End 2021  year 1 of Valium taper at 6mg

End 2022 year 2 of Valium taper at 2.75mg 

End 2023 year 3 of Valium taper at 1mg

Jan. 24, 2024: Hold at 1mg and shift to Imipramine taper.

Taper is 95% complete.


Imipramine 75 mg daily since 1986.  Jan.-Sept. 2016 tapered to 14.4mg  

March 22, 2022: Begin 10%/4 week taper

Aug. 5, 2022: hold at 9.5mg and shift to Valium taper

Jan. 24, 2024: Resume Imipramine taper.  Current dose as of May 2: 6.1mg

Taper is 92% complete.  


Supplements: multiple, quercetin, omega-3, vitamins C, E and D3, magnesium glycinate, probiotic, zinc, melatonin .3mg, iron, serrapeptase, nattokinase

I am not a medical professional and this is not medical advice but simply information based on my own experience, as well as other members who have survived these drugs.

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Thanks Gridley for the info. I have a weighted blanket and supplements that help but this week I have been exhausted every day. My list of foods is getting pretty narrow. I might try meat only. I have heard it helps those with overactive immune systems   

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  • Moderator Emeritus

Hi and welcome from me too,


Please create your drug signature so that we can see your drug history at a glance.  It will appear below every post you make.  Thank you.


Instructions:  Withdrawal History Signature

Account Settings – Create or Edit a signature


MISSION ACCOMPLISHED:  (6 year taper)      0mg Pristiq  on 13th November 2021

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering from Oct 2015 - 13 Nov 2021   LAST DOSE 0.0025mg

Post 0 updates start here    My tapering program     My Intro (goes to tapering graph)

 VIDEO:   Antidepressant Withdrawal Syndrome and its Management

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  • 2 weeks later...

Hi oldlady123


I have also been off remeron for  20 months, and my food intolerance has increased after a year off remeron. I was doing well in winter, and able to to eat more foods.


I am not really sure if our problems are due to histamine intolerance, or due to faulty histamine receptor functioning after stopping remeron.  


I can eat most foods without issues, but when I am in the sleep/wake cycle is when I get a lot of GI flare-ups (mainly gas)

that wake me up or keep me from sleeping. This occurs between midnight and 4am, and  I am guessing that its due to an overload of mast cell activity that could be due to not just food, but also environment (heat, pollen, smoke) and stress (emotional, physical).


My theory is that the nervous system reacts to any significant change in our food and environment - the smaller the change, the less likely to have a histamine flare.


This week I ran an experiment to keep my food mostly consistent, but avoided all protein (esp lentils) at night, and this has helped me get 4 successive nights of sleep until today. I was able to have very small portions of foods that were new or I had not had in a while, without reacting.


Today everything was off the charts - I introduced many new changes - hemp seed, chicken, alcohol, salsa, in addition to attending a funeral outdoors on a smoky and hot day..  and dealing with multiple symptoms - temperature sensitivity, tingling all over, and gut issues.


While we are recovering, it's absolutely important to go very slow and avoid triggering the nervous system.


Chronic IBS since 1990

Former smoker (1992- Jun 2017)

Prescribed mirtazapine for sleep in Aug 2017 after IBS flare-up following Nicotine cessation.

Mirtazapine 7.5mg 8/17 to 5/18

Mirtazapine 3.75mg 5/18 to 1/19

Off Mirtazapine since 2/19.

Vit B, Vit D+K2 and Magnesium Glycinate as needed.

On Ayurvedic herbs for GI issues - Guduchi since Jul 2020, Indukantham since Oct 2020

On Ashwagandha 1g since Nov 2020



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