RemeronHell: Remeron adverse reaction and fallout

[RemeronHell]

Almost 20months out now. Some of the side effects continue to improve. However, in the last 1-2 months have now been basically not able to sleep more than 5 hours. prior to this, was gettting 7avg most nights. Now, no matter what i do or take before bed, i always wake up after 5 hours. I think my REM sleep has basically disappeared. I know mirtazapine can cause issues with REM, didnt realize could be this far out still!    So this has now become my biggest issue im dealing with, whilst others have improved.   Any ideas or tips how to stay asleep?  ive tried magneisum, ashwaghanda, valerian root, herbal teas, L theanine, etc. 

[Chompoo]

@RemeronHell how are you? Has your insomnia improved? I'm like you. I developed an immediate adverse reaction to Remeron after only one dose (15mg). Hope you are doing fine.

[Kristyb1130]

Hi 

I had a reaction after one doze of Lexapro.

but my daughters friends mom took me to the hospital. They gave me other meds and it was a domino effect. I’m off all meds now but have had damage since 9/2020

[RemeronHell]

Sleep is still an issue, most nights waking up after 5 hours, sometimes around 6 and if very lucky 6.5.  I did stop all the vitamins that i was taking. I have a feeling that Tongkat Ali (testosterone booster) which has a potential side effect as insomnia seems to maybe have aggravated my situation. 

[ask2266]

Remeron Hell,

 

I wanted to tell you that your hunch about serotonin syndrome may be correct. People that have trouble getting off Remeron tend to be those with histamine issues already, that is, people who were close to having a histamine disorder before they went on the Remeron. I say this based on observations on these boards that many people I see with benzo or Remeron problems have had other histamine problems like chronic fastigue syndrome, lyme, long covid, mold sensitivity, thyroid problems, autoimmunity, etc.

 

HIstamine disorders are caused when folks have too much histamine in their bodies whether from a lack of enzymes to break histamine down or from mast cells getting activated and not turning off for whatever reason (toxicity, chronic infection, autoimmunity, etc) . I think when people come off Remeron (and benzos), it can trigger mast cell activation in some that gets stuck in the "on" position, no different than when you have a chronic infection for example.  Mast cells release a ton of histamine, and they also release a ton of serotonin. 

 

I actually got serotonin syndrome during my withdrawal from Remeron and had to cold turkey my celexa that I was on because it got so bad. I was having mast cell activation from tapering the Remeron and from covid that I had. There are reports of people getting serotonin syndrome from covid even when they aren't taking any antidepressants, just from the mast cell activaiton caused from fighting the covid. So I think if you were already someone with a low level mast cell histamine problem and you added the serotonin boost from Remeron, I think you conceivably could have had serotonin syndrome.

 

One thing that took away 100% of my Remeron withdrawal symptoms (and some of my long covid symptoms which are similar bc they are both histamine symptoms) was taking the DAO enzyme, which is the enzyme made by your kidneys and your gut that normally eats histamine. You can get it on Amazon. 

 

I wish you continued recovery. All the best, Quinn

[SlowVeil]

hi remeronhell,

 

i found that we share many similar symptoms but our recovery timeline is very different. it's surprising that your muscle twitching/jerking is one of the first symptoms to improve. how is your tinnitus and muscle twitching now? do you still have numbness in your hands and feet?

 

[Kristyb1130]

I was on Albilfy too.. that’s a strong medication 

are you on any meds now? 
im off all meds since 2021 Nov 

[RemeronHell]

Sorry for the delay in reply.  The sleep issue i was last talking about improved and essentially I felt like life was virtually back to normal.   So i was finally able to get my life back !         And everything was generally fine  (tinnitus is the only issue that seems like it will be permanent,   but it doesnt bother me so much). 

 

However, this last 1wk i started to experience certain symptoms that closely resembled those side effects when i was taking Mirt  (light headedness,  headache, feeling like want to pass out, generalized weakness).   The timeline seems to match the following:  I did start to take 2 new supplements (Moringa and L-Carnitine). I was taking the moringa as part of a banana smoothie i was making each day, and then L carnitine was 1 small "shot" bottle which is used pre exercise (3000mg L-Carnitine for energy boost).   I later looked up online and realised that both of these supplements can increase noradrenline, dopamine and serotonin.    The L Carnitine also specifically mentions side effects which are reflected in some of the things i expereinced.    I am  now concerned that, even after basically being OK for over a year,  I have  "rekindled" myself and maybe am in a light new "wave"  or mini withdrawal episode ? 

 

Has anyone experienced or read about anything like this?    I am hoping this will just last a few days or week or so....i would hate to think I have to go back to months on end of enduring this   all over again (granted, this time around feels not as bad as the initial Mirt side effect + WD episode, which was hell).