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NewQuestions: Anyone suffering from hypersensitivity/kindling effect tried Ketamine?

NewQuestions

By NewQuestions
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NewQuestions Newbie

NewQuestions

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New here.

 

I was on Zoloft for 7 or 8 years.  It pooped out and otherwise made me feel tired and lethargic with crazy brain fog.  I transitioned to Lexapro, then basically

every other drug (SSRI, SNRI, BENZOS, MAOI and others) for the next 6 years but nothing worked.  It took me a while to figure it out but I became hypersensitive to the drugs.  I decided to taper off them in 2009.  After a couple of months, my brain crashed.  Headache, dizziness, difficult concentrating, internal restlessness, tingling, hypersensitivity to light/sun/exercise. Its 24/7 and lasted since 2009.

 

Because of the hypersensitivity, I am convinced that any drug that targets serotonin receptors I will overreact too.

 

Since Ketamine works in a different way, I am considering giving it a try.  My understanding is that it is an NMDA receptor antagonist. It binds to the NMDA receptor protein on cell membranes and blocks glutamate from binding there.

 

Has anyone suffering from hypersensitivity/kindling tried Ketamine?

1995-2003: Zoloft (experienced poopout/adverse affects such as lethargy and brain fog)

2004-2005: Lexapro (same problems)

2005-2008: Cycled through other drugs but overreacted to everything

2008: Concluded I was hypersenitive and went off everything

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  • KenA changed the title to NewQuestions: Anyone suffering from hypersensitivity/kindling effect tried Ketamine?
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FireflyFyte Contributor

FireflyFyte

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  • Moderator
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Hi NewQuestions,

 

Welcome to SA. Please summarize your drug history in your signature by following the instructions at How to Summarize Your Drug History in Your Signature. You may need to be on a computer to complete this.

 

We do not recommend ketamine as a treatment but we do have a thread dedicated to it at Ketamine and esketamine treatment

 

Thanks,

 

Firefly

 

Pre- October 2022: Wellbutrin, Escitalopram, Citalopram, Sertraline, Adderall IR, Vyvanse, Propranolol, Buspar, Ativan, and Latuda

Oct 13, 2022 - Oct 24, 2022 and Oct 31, 2022 - Present: Zyprexa (2.5 mg). Jan 14, 2023 -> Began transition to liquid suspension. Jan 29, 2023 = 2.375mg -> Feb 12, 2023 = 2.25mg -> Feb 27, 2023 = 2.14mg -> Mar 12, 2023 = 2.025mg -> Mar 27, 2023 = 1.93mg -> Apr 10, 2023 = 1.82mg -> Apr 23, 2023 = 1.74mg -> May 7, 2023 = 1.64mg -> May 21, 2023 = 1.56mg -> June 4, 2023 = 1.48mg -> June 19, 2023 = 1.4mg -> July 2, 2023 = 1.33mg -> July 16, 2023 = 1.26mg -> July 31, 2023 = 1.2mg -> Aug 13, 2023 = 1.14mg -> Aug 27, 2023 = 1.08mg -> Sep 13, 2023 = 1.02mg -> Jan 22, 2024 = 0.97mg -> Feb 4, 2024 = 0.92mg -> Feb 19, 2024 = 0.87mg -> Mar 3, 2024 = 0.83mg -> Mar 17, 2024 = 0.78mg -> Mar 31, 2024 = 0.74mg -> Apr 14, 2023 = 0.7mg

Oct 14, 2022 - Present: Prozac (40mg) upped from 20mg on Nov 1, 2022.

Oct 31, 2022 - Present: Gabapentin (300mg 3x day) -> May 3, 2023 = 300mg 2x day -> Oct 1, 2023 = 570mg -> Oct 15, 2023 = 540mg -> Oct 29, 2023 = 510mg -> Nov 13, 2023 = 484mg -> Nov 27, 2023 = 460mg -> Dec 9, 2023 = 436mg -> Dec 24, 2023 = 414mg -> Jan 7, 2024 = 400mg

 

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