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Tips for tapering off Seroquel (quetiapine)


mutley
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I just tried the suspension in liquid. 25mg in 25ml and followed the video. I waited 4 hours for it to "dissolve" even if it's not really disolving. But there is a lot of particles dropped at the bottom, even by shaking, it's like if a lot of it is heavier than water. The water is still white so I probably got medecine from it, but I don't know if my 6.25ml contains really 6.25mg, even 6mg. It's kind of worrying. I should know the result pretty fast since insomnia strikes somewhere under 6mg. Usually, I know at 3am when my sleep is totally disabled and that I will not sleep at all of the night. Since we are in the week-end, it should not have too much consequences, but I can't do this more than 2 nights. I will have to sleep at least to work for monday. So in case of total failure, I will have to take 6.25 in solid form again before to find another way. I will just stay positive for now and hope for the best. I've also a worry that I may never be able to sleep again without seroquel, but well, in August when I tried cold-turkey from 50mg xr, the third night I was able to get one to two hours or sleep even if it tooks until 6am...So it was showing some kind of progress I guess, letting think it will not stay forever. But without 3 nights of sleep I was too broken to continue. I felt those 3 days like 3 weeks and I've decided to not screw my holidays anymore and wait later for another solution. At least I knew against what I was fighting. You know, I got not a trace of insomnia before, from 400 to 12.5. I got some at 6.25 "sometimes" because the cut cannot be straight and accurate, probably, so I must have maybe 4-5mg one day, 7 the other and 6 when I'm lucky... I think there is a trigger somewhere under 6.25 that disable sleep. I thought that if I was able to find it, for example at 5mg, I could wait above at 5.5mg some days, wait for it to vanish, and then go to 5, wait again, and finally get rid of this until 0. But seeing all those suspended particles, I'm worried for now.

1999-2003: not really remember. Tried Wellbutrin for a week, being mostly on Paxil

2004-2009: zoloft 200mg

2009-2010: zoloft fast withdrawal (-25mg per week), added celexa a few months, minimum dose)

2010: zoloft 200mg + zyprexa

2011: zoloft 200mg + seroquel XR 400mg, zyprexa removed

2014 (April): zoloft 0mg tapered -25mg per 2 weeks. Still having seroquel XR 400mg

2014 (July): restarted zoloft 25mg for unbearable symptoms. Still having seroquel XR 400mg

2018 (May): zoloft 0mg tapered -25mg per 2 weeks. Still having seroquel XR 400mg

2020 (May to August): seroquel XR -100, -100, -50, -50, -50 = 0mg on August 4th, reinstated to 50mg XR after 4 days

2020 Sept 21: seroquel 25mg

2020 Oct 12: seroquel 12.5mg

2020 Nov 2: seroquel 6.25mg, 21: seroquel 5mg, 22: seroquel 4mg, 24: seroquel 3mg, 28: seroquel 2mg. Dec 4 : 1mg, 5: 0.5mg, Dec 19: 2mg, 2021 Jan 16: 1.5mg, Jan 22: 1mg, Jan 23: 0.5mg, Jan 29: 0.25mg, Feb 06: 0.125mg, Feb 07: 0.06mg, Fev 11: 0.125mg, Fev 18: 0.1875mg, Mar 13: 0.09mg + clonazepam 0.25mg, Mar 19: seroquel 0mg, clonazepam 0.25mg, Apr 23: clonazepam 0.5mg, Oct 21: clonazepam 0.75mg

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Seroquel has a solubility rate of 3.3mg/mL of water. So there should be  no problem with all the active ingredient dissolving into the water. The particles you are seeing are bits of filler material that no longer matter.

20 years on Paxil starting at 20mg and working up to 40mg. Sept 2011 started 10% every 6 weeks taper (2.5% every week for 4 weeks then hold for 2 additional weeks), currently at 7.9mg. Oct 2011 CTed 15oz vodka a night, to only drinking 2 beers most nights, totally sober Feb 2013.

Since I wrote this I have continued to decrease my dose by 10% every 6 weeks (2.5% every week for 4 weeks and then hold for an additional 2 weeks). I added in an extra 6 week hold when I hit 10mg to let things settle out even more. When I hit 3mgpw it became hard to split the drop into 4 parts so I switched to dropping 1mgpw (pill weight) every week for 3 weeks and then holding for another 3 weeks.  The 3 + 3 schedule turned out to be too harsh so I cut back to dropping 1mgpw every 4 weeks which is working better.

Final Dose 0.016mg.     Current dose 0.000mg 04-15-2017

 

"It's also important not to become angry, no matter how difficult life is, because you can loose all hope if you can't laugh at yourself and at life in general."  Stephen Hawking

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41 minutes ago, brassmonkey said:

Seroquel has a solubility rate of 3.3mg/mL of water. So there should be  no problem with all the active ingredient dissolving into the water. The particles you are seeing are bits of filler material that no longer matter.

Reading this do me a lot of good. Thank you. I really hope it will work.

1999-2003: not really remember. Tried Wellbutrin for a week, being mostly on Paxil

2004-2009: zoloft 200mg

2009-2010: zoloft fast withdrawal (-25mg per week), added celexa a few months, minimum dose)

2010: zoloft 200mg + zyprexa

2011: zoloft 200mg + seroquel XR 400mg, zyprexa removed

2014 (April): zoloft 0mg tapered -25mg per 2 weeks. Still having seroquel XR 400mg

2014 (July): restarted zoloft 25mg for unbearable symptoms. Still having seroquel XR 400mg

2018 (May): zoloft 0mg tapered -25mg per 2 weeks. Still having seroquel XR 400mg

2020 (May to August): seroquel XR -100, -100, -50, -50, -50 = 0mg on August 4th, reinstated to 50mg XR after 4 days

2020 Sept 21: seroquel 25mg

2020 Oct 12: seroquel 12.5mg

2020 Nov 2: seroquel 6.25mg, 21: seroquel 5mg, 22: seroquel 4mg, 24: seroquel 3mg, 28: seroquel 2mg. Dec 4 : 1mg, 5: 0.5mg, Dec 19: 2mg, 2021 Jan 16: 1.5mg, Jan 22: 1mg, Jan 23: 0.5mg, Jan 29: 0.25mg, Feb 06: 0.125mg, Feb 07: 0.06mg, Fev 11: 0.125mg, Fev 18: 0.1875mg, Mar 13: 0.09mg + clonazepam 0.25mg, Mar 19: seroquel 0mg, clonazepam 0.25mg, Apr 23: clonazepam 0.5mg, Oct 21: clonazepam 0.75mg

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  • 3 weeks later...

I got a confirmation from a pharmacist that a liquid solution will likely to degrade in efficiency with days, that we don't know much also about efficiency in water. I'm at 1mg so efficiency is very important for stability. So the found solution is to prepare a new solution every day to be sure to have the same amount/efficiency of med each time (again suggested by the pharmacist). So I report it if it may help someone at tiny doses like me. Also, do we know if the 4h are really necessary for let the pill in water? I use 25mg, it spread very fast and I don't really have the time each day to prepare this 4h before taking it. 2h for example, would be easier, but I don't want to screw up the total suspension process. Do we know if it works under 4h for 25mg? Thanks.

1999-2003: not really remember. Tried Wellbutrin for a week, being mostly on Paxil

2004-2009: zoloft 200mg

2009-2010: zoloft fast withdrawal (-25mg per week), added celexa a few months, minimum dose)

2010: zoloft 200mg + zyprexa

2011: zoloft 200mg + seroquel XR 400mg, zyprexa removed

2014 (April): zoloft 0mg tapered -25mg per 2 weeks. Still having seroquel XR 400mg

2014 (July): restarted zoloft 25mg for unbearable symptoms. Still having seroquel XR 400mg

2018 (May): zoloft 0mg tapered -25mg per 2 weeks. Still having seroquel XR 400mg

2020 (May to August): seroquel XR -100, -100, -50, -50, -50 = 0mg on August 4th, reinstated to 50mg XR after 4 days

2020 Sept 21: seroquel 25mg

2020 Oct 12: seroquel 12.5mg

2020 Nov 2: seroquel 6.25mg, 21: seroquel 5mg, 22: seroquel 4mg, 24: seroquel 3mg, 28: seroquel 2mg. Dec 4 : 1mg, 5: 0.5mg, Dec 19: 2mg, 2021 Jan 16: 1.5mg, Jan 22: 1mg, Jan 23: 0.5mg, Jan 29: 0.25mg, Feb 06: 0.125mg, Feb 07: 0.06mg, Fev 11: 0.125mg, Fev 18: 0.1875mg, Mar 13: 0.09mg + clonazepam 0.25mg, Mar 19: seroquel 0mg, clonazepam 0.25mg, Apr 23: clonazepam 0.5mg, Oct 21: clonazepam 0.75mg

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  • 1 year later...

Tapering quetiapine, advice as taking XR.. how to taper in small amounts on XR? Switch to instant?

 

I’m on quetiapine 112.5 

I take 2 50mg Extended release and a quarter of the 50mg for the 12.5 which makes it instant. 
 

I need to taper down more, my Phyc has said to switch completely over to instant, I have always taken the XR and came from taking 400mg ! 
 

needing to do a slow taper and cut pills. 
some People say take one 50mg XR and the rest 25mgs instant and cut them. So it’s half and half … 

 

I take this at night.

any advice welcomed ! 
xx

 

Edited by ChessieCat
added topic title before merging with existing topic

- Nov 2020 –  Feb 2021 Lorazepam (1mg) for tinnitus. 

-(1,5- 2mg) till April (2021), tapered off for 1 week, reinstated in May 1mg - 2mg got worse

- Switched Ativan to diazepam 10mg 5 weeks from 10mg -3,5mg got worse

- March 2021 6 weeks Lexapro 15mg, quit (tapered of in 3weeks) took for anxiety made me a vegetable, better once off.

May Hospital - quetiapine once at 50mg, then olanzepine, hypotension I stopped everything. Severe symptoms, not sleeping.

- 2021 - 2mg ativan given twice in hospital drug induced Psychosis - July 2021 hospital  risperidone 2mg-6mg in 1 week  +30mg Mirtazipine total 2 weeks - I stopped for 1 week ( thought I was being poisoned ) had window of 10 days slowly some normality,  started at 3mg Risp for 10days + 15mg Mirtazipine because I worried for withdrawal, but too late was hit with intense withdrawal, uncontrollable symptoms 

- Sept 3 hospital  – Oct 13th -quetiapine within 1 week 50mg-400mg + 30 mg mirtazapine 

- 6 weeks in hospital  - Home -  300 mg for 4 weeks

 - Reinstated 24th Nov - 0.5 Ativan - stabilised - 1st Dec went to 150mg quetia - 24thDec went to 100mg - Went to 31st Dec 112.5 - 30th Jan 100mg holding. Dropped -22nd March, Mirt -26mg - 9th May, Mirt -25mg.  I take Quetiapine and MIrtazipine at night before bed 22pm, I take Ativan in the morning 9am-10am and in the early eve 17.00 splitting the 0.5

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  • Moderator Emeritus

@Emma86

 

Have you read post #1 of this topic?

 VIDEO:   Antidepressant Withdrawal Syndrome and its Management

 

MISSION ACCOMPLISHED:    (6 year taper)      0mg Pristiq      on 13th November 2021

Woohoo!!!  Finally off Pristiq    Post 0 updates start here

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering from Oct 2015 - 13 Nov 2021   LAST DOSE 0.0025mg

My full tapering program     My Intro (goes to my tapering graph)    My website

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions.  Please DO NOT TAG me - thank you.

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22 hours ago, Emma86 said:

I need to taper down more, my Phyc has said to switch completely over to instant, I have always taken the XR and came from taking 400mg ! 
 

You are used to XR release. In my opinion not a good idea to switch to instant release. Since you are not stable yet and since you are taking also the Lorazepam and Mirtazapine, I would not change any form of a drug you are taking. Keep everything as stable as it is. There is not one good reason to change from XR to instant release.

 

You can easily combine XR (50 mg pills) and add the extra needed dosage in instant release. In that way most of the dosage taken will remain XR. Keep things as most as possible stable during tapering.

1993    Anafranil (Clomipramine) for a few months. Later in 1993 Paxil for a few months 1993- 2006      No medication

2006   Effexor, Cymbalta, some Benzo’s. All for short periods. Later in 2006 Lexapro (escitalopram) 10 mg and shortly after Wellbutrin XR 150mg, against side effects Lexapro 

Since 2006 until end of 2015: Several times on and off Lexapro and Wellbutrin and several slight dosage changes. Mostly taken dosages: 5mg Lexapro and 150mg Wellbutrin

2016  Dosage change Lexapro from 5mg to 2,5 mg. Wellbutrin stayed om 150mg

November 2016 – April 2017 Down from 2,5mg to 0,6mg Lexapro (in steps) without much problems. Wellbutrin down from 150mg to 66mg. Also without much problems.

April 2017 – March 2019       Lexapro 0,6 mg        April 2017 - August 2018       Wellbutrin in small steps down from 66mg in to 37,5 mg . Quite heavy WD after each step.

March 2019 – May 2019 Lexapro down from 0,6 to 0,3mg then Prozac to 0,6 mg switch because severe discontinuation effects (may also have been from Wellbutrin..)    

Wellbutrin down from 37,5mg to 35,3mg 

October 2019        Seroquel 12,5 mg for 4 weeks because of extreme sleeping problems, then weaning off in 2 weeks       Prozac up dosage to 1,2 mg

March 2020     Wellbutrin in 2 steps down from 35,3mg to 33,3mg   Extreme withdrawal affects during 8 months. Stopped tapering Wellbutrin  until total off Prozac. 

February 2020 – November 2020   Prozac down in steps from 1,2mg to 0,57mg. 

Jan 2021  Prozac down to:  0,55> 0,53>0,51mg,   Feb 0,47mg ,  Mar 0,42mg,   Apr 0,37, longer hold because of WD symptoms July 0,36 and hold again, Sept 19 0,35, Sept 26 0,34mg, Oct 3 0,33mg  

January 20, 2022:  Wellbutrin from 33,3 to 32,3mg

March 22, 2022 Prozac down from 0,33mg to: 0,30mg, Apr 0,29, May 0,28, 0,27, June 0,26, 0,25, July 0,24, 0,23, 0,22, 0,21, Aug 

 

Supplements: Fish Oil (3000mg), Magnesium 100 mg, 2 drops of Lavender Oil when feeling anxiety. 50mg of L-Theanine when severe discontinuation effects caused by Wellbutrin

 

Please note this is NOT a medical advice. Discuss all your medical issues with a doctor who understands psychical drugs and really knows how to withdraw from them. I wish that you will find one.

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I've read somewhere in this thread that it can be a big hit to go from XR to standard. And I tested it myself. After the minimal XR pill, I switched to standard and got sudden muscle fatigue and pain in all articulations, so much that nothing could explain this otherwise. I was even not able to carry a backpack above 10min when normally, I was doing it often during all summer and for hours. It happened during the first week, and it was brutal. So tapering from XR itself is a kind of parallel taper it seems.

1999-2003: not really remember. Tried Wellbutrin for a week, being mostly on Paxil

2004-2009: zoloft 200mg

2009-2010: zoloft fast withdrawal (-25mg per week), added celexa a few months, minimum dose)

2010: zoloft 200mg + zyprexa

2011: zoloft 200mg + seroquel XR 400mg, zyprexa removed

2014 (April): zoloft 0mg tapered -25mg per 2 weeks. Still having seroquel XR 400mg

2014 (July): restarted zoloft 25mg for unbearable symptoms. Still having seroquel XR 400mg

2018 (May): zoloft 0mg tapered -25mg per 2 weeks. Still having seroquel XR 400mg

2020 (May to August): seroquel XR -100, -100, -50, -50, -50 = 0mg on August 4th, reinstated to 50mg XR after 4 days

2020 Sept 21: seroquel 25mg

2020 Oct 12: seroquel 12.5mg

2020 Nov 2: seroquel 6.25mg, 21: seroquel 5mg, 22: seroquel 4mg, 24: seroquel 3mg, 28: seroquel 2mg. Dec 4 : 1mg, 5: 0.5mg, Dec 19: 2mg, 2021 Jan 16: 1.5mg, Jan 22: 1mg, Jan 23: 0.5mg, Jan 29: 0.25mg, Feb 06: 0.125mg, Feb 07: 0.06mg, Fev 11: 0.125mg, Fev 18: 0.1875mg, Mar 13: 0.09mg + clonazepam 0.25mg, Mar 19: seroquel 0mg, clonazepam 0.25mg, Apr 23: clonazepam 0.5mg, Oct 21: clonazepam 0.75mg

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  • 2 weeks later...
  • Moderator Emeritus

I have moved posts about Emma's questions with the responses to Emma86's Introduction topic which you can find here:

 

 

 VIDEO:   Antidepressant Withdrawal Syndrome and its Management

 

MISSION ACCOMPLISHED:    (6 year taper)      0mg Pristiq      on 13th November 2021

Woohoo!!!  Finally off Pristiq    Post 0 updates start here

ADs since ~1992:  25+ years - 1 unknown, Prozac (muscle weakness), Zoloft; citalopram (pooped out) CTed (very sick for 2.5 wks a few months after); Pristiq:  50mg 2012, 100mg beg 2013 (Serotonin Toxicity)  Tapering from Oct 2015 - 13 Nov 2021   LAST DOSE 0.0025mg

My full tapering program     My Intro (goes to my tapering graph)    My website

PLEASE NOTE:  I am not a medical professional.  I provide information and make suggestions.  Please DO NOT TAG me - thank you.

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  • 3 weeks later...

Somebody has ever tapering the XR version by dry cutting and using a scale? I'm going to taper 50 mg of quetiapine XR and see many places saying that it is not possible to cut these. I'm afraid of switch to IR and have more side effects because in the past I took 100mg IR and had blood pressure issues after take the dose. In the case of taking 25mg at night and 25mg in the morning, it can make more sleepy than with the XR during the day? Can I made something like  37.5mg at night and 12.5 in the morning and see if it works?

2015-2016: Start treatment for anxiety and gastrointestinal issues due to it. Almost 1 year on lexapro and become worst. Tried zoloft for 2 months and had severe diarrhea. May 2016: Extreme irritability with paroxetine (1 month) lead to Bipolar 2 diagnosis (now I know it was a medical error) 

2016-2018: Quetiapine XR started at 150mg, down to 50mg due to somnolence. Doc put a lot of mood stabilizers and antipsychotics with bad reactions, most of them taken during 1-2 months. Only Depakote was used for almost 1 year. 

jul-aug 2018: Bad reaction to lamotrigine put me on severe depression (never had something like that in my life)

sep 2018: Quetiapine XR 100, Amisulpride 100mg to deal with severe depression induced by lamotrigine (now I know it was a medical error) - 2019: Reduced Quetiapine XR to 50mg and Amisulpride to 0 in 6 months without issues.

2020: Quetiapine XR 50mg. Feels good.

Apr 2021: Medical error lead me to take 300mg of Quetiapine. Was at hospital for 5 days with heart issues but not was found. Realize at home the wrong dosage and went back to 50mg. 

May 2021: Due to change of dosage, had a 3 month withdrawal without knowing it. Doc said I was with anxiety and panic. Introduced again 50mg Amisulpride. Couldn't tolerate and after two days went down to half a pill (25mg). 

Jun 2021: Still in withdrawal. Doc put me on 1.25 olanzapine (he wanted 2.5, but I was afraid of some bad reaction) and 1mg clonazepam. 

Jul 2021: Started tapering clonazepam by reduced one drop per week.

Sep 2021: End clonazepam tapering. Start to have withdrawal again. Two weeks in bed. Start to suspect my doc was insane and look for another. Found a doctor who was not too pro-med. After three sessions he told me I was not bipolar. I have anxiety and he wants to treat with therapy. Start reducing olanzapine (he said it's a bad drug) to 0.9325mg.

Oct 2021: Quetiapine XR 50mg, Amisulpride 25mg, Olanzapine 0.625mg

Nov 2021: Quetiapine XR 50mg, Amisulpride 25mg, Olanzapine 0.3125mg. Things went bad, had two nights of inmsonia, nausea and extreme anxiety. After that, things start improving slowly. 1 1/2 week later I'm better, but still have some tiredness and chest pressure. Most of the days I sleep well, but last night I didn't sleep good. 

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