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Tips for tapering off Seroquel (quetiapine)


mutley

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I just tried the suspension in liquid. 25mg in 25ml and followed the video. I waited 4 hours for it to "dissolve" even if it's not really disolving. But there is a lot of particles dropped at the bottom, even by shaking, it's like if a lot of it is heavier than water. The water is still white so I probably got medecine from it, but I don't know if my 6.25ml contains really 6.25mg, even 6mg. It's kind of worrying. I should know the result pretty fast since insomnia strikes somewhere under 6mg. Usually, I know at 3am when my sleep is totally disabled and that I will not sleep at all of the night. Since we are in the week-end, it should not have too much consequences, but I can't do this more than 2 nights. I will have to sleep at least to work for monday. So in case of total failure, I will have to take 6.25 in solid form again before to find another way. I will just stay positive for now and hope for the best. I've also a worry that I may never be able to sleep again without seroquel, but well, in August when I tried cold-turkey from 50mg xr, the third night I was able to get one to two hours or sleep even if it tooks until 6am...So it was showing some kind of progress I guess, letting think it will not stay forever. But without 3 nights of sleep I was too broken to continue. I felt those 3 days like 3 weeks and I've decided to not screw my holidays anymore and wait later for another solution. At least I knew against what I was fighting. You know, I got not a trace of insomnia before, from 400 to 12.5. I got some at 6.25 "sometimes" because the cut cannot be straight and accurate, probably, so I must have maybe 4-5mg one day, 7 the other and 6 when I'm lucky... I think there is a trigger somewhere under 6.25 that disable sleep. I thought that if I was able to find it, for example at 5mg, I could wait above at 5.5mg some days, wait for it to vanish, and then go to 5, wait again, and finally get rid of this until 0. But seeing all those suspended particles, I'm worried for now.

1999-2003: not really remember. Tried Wellbutrin for a week, being mostly on Paxil

2004-2009: zoloft 200mg

2009-2010: zoloft fast withdrawal (-25mg per week), added celexa a few months, minimum dose)

2010: zoloft 200mg + zyprexa

2011: zoloft 200mg + seroquel XR 400mg

2014 (April): zoloft 0mg tapered -25mg per 2 weeks. Still having seroquel XR 400mg

2014 (July): restarted zoloft 25mg for unbearable symptoms. Still having seroquel XR 400mg

2018 (May): zoloft 0mg tapered -25mg per 2 weeks. Still having seroquel XR 400mg

2020 (May to August): seroquel XR -100, -100, -50, -50, -50 = 0mg on August 4th, reinstated to 50mg XR after 4 days

2020 Sept 21: seroquel 25mg

2020 Oct 12: seroquel 12.5mg

2020 Nov 2: seroquel 6.25mg

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brassmonkey

Seroquel has a solubility rate of 3.3mg/mL of water. So there should be  no problem with all the active ingredient dissolving into the water. The particles you are seeing are bits of filler material that no longer matter.

20 years on Paxil starting at 20mg and working up to 40mg. Sept 2011 started 10% every 6 weeks taper (2.5% every week for 4 weeks then hold for 2 additional weeks), currently at 7.9mg. Oct 2011 CTed 15oz vodka a night, to only drinking 2 beers most nights, totally sober Feb 2013.

Since I wrote this I have continued to decrease my dose by 10% every 6 weeks (2.5% every week for 4 weeks and then hold for an additional 2 weeks). I added in an extra 6 week hold when I hit 10mg to let things settle out even more. When I hit 3mgpw it became hard to split the drop into 4 parts so I switched to dropping 1mgpw (pill weight) every week for 3 weeks and then holding for another 3 weeks.  The 3 + 3 schedule turned out to be too harsh so I cut back to dropping 1mgpw every 4 weeks which is working better.

Current dose 0.000mg 04-15-2017

 

"It's also important not to become angry, no matter how difficult life is, because you can loose all hope if you can't laugh at yourself and at life in general."  Stephen Hawking

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41 minutes ago, brassmonkey said:

Seroquel has a solubility rate of 3.3mg/mL of water. So there should be  no problem with all the active ingredient dissolving into the water. The particles you are seeing are bits of filler material that no longer matter.

Reading this do me a lot of good. Thank you. I really hope it will work.

1999-2003: not really remember. Tried Wellbutrin for a week, being mostly on Paxil

2004-2009: zoloft 200mg

2009-2010: zoloft fast withdrawal (-25mg per week), added celexa a few months, minimum dose)

2010: zoloft 200mg + zyprexa

2011: zoloft 200mg + seroquel XR 400mg

2014 (April): zoloft 0mg tapered -25mg per 2 weeks. Still having seroquel XR 400mg

2014 (July): restarted zoloft 25mg for unbearable symptoms. Still having seroquel XR 400mg

2018 (May): zoloft 0mg tapered -25mg per 2 weeks. Still having seroquel XR 400mg

2020 (May to August): seroquel XR -100, -100, -50, -50, -50 = 0mg on August 4th, reinstated to 50mg XR after 4 days

2020 Sept 21: seroquel 25mg

2020 Oct 12: seroquel 12.5mg

2020 Nov 2: seroquel 6.25mg

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