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Post-withdrawal nervous system hypersensitivity or kindling

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Daisies24

Thanks for the responses. LexAnger, I am sorry that these symptoms are happening to you, too!

 

My symptoms started roughly 3 months or so after stopping Prozac. Before that, I took several supplements with absolutely no problems. When did this begin for you?

 

Bluebird, I am so sorry about the early morning awakening. I know that is an awful feeling. The only thing I wonder for you is if you could find a totally pure brand of magnesium with no fillers

(maybe it would not irritate your system that way), and when you wake up with that anxiety, take the magnesium and see if you begin to calm down enough to go back to sleep?

 

MammaP, that is great that you are getting better, even though you are still highly sensitive. The fact that you can see your body healing to at least some degree, even if small, has to be encouraging! Thanks for pointing out that this really does happen with more drugs than just Prozac--my reading about this has probably been more selective than I had realized, which is why I thought I noticed a correlation. I do think my symptoms sound like an allergic reaction, also, which I never had before the Prozac, so that is why I am especially curious if others experience these kinds of symptoms.

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Bluebird2009

Daisies24 thankyou, where wld I buy this pure magnesium? Also I get a bit of throat swelling with my sensitivity but not enough to cause a problem, but the rapid heart, tight chest, weakness and a hole hostvof other things r horrific. You're sounds like an allergy mind you. Mammap I'm glad your sensitivity is settling, mine is whatvis keeping me so ill!

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scallywag

Because magnesium is highly reactive in the presence of oxygen, you can't buy magnesium on its own as a supplement.

 

Commercially available supplements will provide a magnesium salt: magnesium citrate, magnesium glycinate, magnesium malate, magnesium oxide, magnesium HVP chelate, etc. You'll have to look at the ingredients list to see what else the manufacturer includes.

 

Pure Encapsulations, a brand suggested to me by a naturopath, has a magnesium glycinate product with only one additive, a form of vitamin C called ascorbyl palmitate.

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compsports

Hi Daisies,

 

Even though I have been off of psych meds since 2010, I am very sensitive to meds and supplements.  Now before you get worried, I am also having sleep issues thanks to being on psych meds long term so that could be contributing to the problem.

 

I don't have your symptoms but I seem to get very agitated with an increased heart rate.  In fact, one time, I falsely thought I perhaps needed to go back on BP meds when actually, I was reacting to a supplement.

 

Sorry you are experiencing the troubles that you are and I hope things improve.

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Bluebird2009

I have the fast heart rate after taking anything it is horrible.

Edited by ChessieCat
Corrected iris to it is

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Daisies24

Scallywag, thanks for the clarification about the magnesium. I never knew that that was the reason you cannot buy magnesium alone as a supplement, but have wondered about that. Bluebird, I do have the Pure Encapsulations magnesium glycinate that Scallywag recommended, and I think there’s a good chance it might help you a little. For me, I seem to be allergic to the cellulose in the capsule encasing, but not sensitive to the ingredients in that particular magnesium capsule. So for instance, I can take Pure Encapsulations magnesium glycinate and feel significantly calmer—no racing heart or anything like that. But, I just happen to also get hives, itching, etc., which I am finding I get with other cellulose capsules as well. If hives and itching aren’t a problem for you, I think there’s a good likelihood that you may tolerate this brand really well. Maybe it’s worth a try for those early morning awakenings when you have anxiety?

 

Compsports, thank you so much for the reply. I am really sorry about the sleep problem. I have this too, and it is actually my worst problem. I really, really hope that you (and all of us dealing with this) will improve—it is truly awful.

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scallywag

Daisies, you can test whether your reaction is to the cellulose capsule by taking the powder only:

  1. Open the capsule.
  2. Dump the contents in to water or applesauce.
  3. Stir.
  4. Consume.

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Bluebird2009

Daisies24 thankyou for your reply. I went to my health shop and got some powder magnesium and tried it. I had fast heartbeat and shaking legs after the magnesium and on the 3rd day I took awful bladder pain and pain in my kidney with a lot of running to the toilet. My system is just in an awful hypersensitive state at the moment and the slightest thing is causing issues. I really hoped I cld take the magnesium but it was causing too many symptoms. I'm really struggling at the moment and if my nervous system wld just settle I feel I wld be on my way to recovery. My depression has lifted again thank gdness.

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Daisies24

Scallywag, thanks for the suggestion. I am experimenting with this now to see how it goes.

 

Bluebird, I am so sorry for the bad reaction. That is awful. Did your magnesium have any kind of fillers in it? Have you already eliminated all unnecessary medications, supplements, artificial foods and additives, even common household cleaner chemicals to see if that will start giving your nervous system a rest?

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Bluebird2009

Hi daisies24, I'll have to check what else wld be in the magnesium but my body reacts to everything I try to take natural or prescription it is truely horrific. It started my last year on the Prozac and I didn't know Prozac was the cause and continued to take it and think that made things worse and then withdrawal just sent the nervous system crazy. I can't even take root ginger which is supposed to be good for me. I have changed my diet and try to stay away from chemicals I find car fumes etc make me feel awful. My anxiety is very high aswell so prob not helping but it's difficult to lower it down. Thanks

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IrishMonkey92

I CT'd with some symptoms for the first 3 months. Then 5 months out, I had a heavy night of drinking, then I took a panic attack and it felt like I was falling through the ground. I went to hospital and all hell broken lose.

I'm been on a rocking/swaying boat, eye floaters, ringing ears ever since (16 months ago). Would that indicate withdrawal/kindling? 

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mustangwoman

Any updates on this anyone?  I have been having sensitivity/adverse effects to almost all meds and several foods for several years myself.  I am  ( at least 6- 7) wondering if this will ever improve.  I haven't been able to take iron, phenergan, antihistamines, most antibiotics, tylenol, topical lidocaine, multivitamins, b vitamins (can tolerate 2000 units of vitamin D now wasn't able to take any 1 year ago).   All which were medications that I could try with no issues prior to SSRIs.  The only medication I can tolerate is advil.  I have been advised by my primary care and ob/gyn to have a breast reduction, but am too concerned about the anesthesia, (and epinephrine and lidocaine usually used during this procedure).  I am on such a low dose now I wonder if the problem has been the luvox, due to the many, many drug interactions, or the withdrawal as I have been tapering for such a long period. 

I also have not been able to tolerate many smells sine approximately 7 years ago.  I can't walk through the laundry aisle at the grocery store.  My husband will get the free and clear laundry detergent that I can tolerate being around, and we have found a shampoo that doesn't cause problems, and ivory soap seems to not cause issues.  I feel sorry for my teenage daughters as I cannot tolerate perfume, nail polish, and many other smells that I use to have no problem at all with before.  I would please like to know if anyone has improved with their sensitivities/ severe adverse reactions to medications/supplements, foods, and smells. 

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Cherry47

Bluebird2009, sorry I missed your post. Mostly I feel grossly ill throughout my whole body as you said, which is the same as the major symptom I still fight these days. I just get swamped by these random waves of gross illness and any meds etc brings this on. I had a quarter of a natural laxative the other day which was enough to upset me.

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mustangwoman

So, no one has recovered from this aspect of ssri use and withdrawal?

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Chuck83

I am now supersensitive to all the drugs I try, or supplements, even my physician is amazed at a lot, he thinks I can be sensitive to ONE medical treatment like the psycho-pharmacological. But He can not understand how any other medication or medical precedure can hurt me, It is also said that he does not know anything about WD, and about hypersensitivity to the nervous system like all doctors, or other MD students like  my colleagues, Who They are always amazed at how I react badly to each drug.

Unfortunately, in a few months, I may need surgery to solve my hemorrhoidal pathology problem, and I am very afraid of reacting to anesthesia.

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mustangwoman

I'm sorry you are going through this.  Let us know how you do/

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Bluebird2009

So, no one has recovered from this aspect of ssri use and withdrawal?

I have spoken to people on other sites who have recovered from this sensitivity to meds problems, but I think it takes a while. One girl recovered after 3.5years

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mustangwoman

Thank you Bluebird!  That is some hope, and hope is so important!  :)

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Scorpio

Hopefully somebody can give me some advice. Unaware until I found this site, that withdrawal can make you so sensitive to medicines etc. 

I was on a steroid inhaler for about four years before citaloprom pooped on me. Went into withdrawal a couple of months later or so I thought. Developed blister rash around my mouth and chin, cramp in legs and toes, purple bruising on hands and arms, more facial hair on upper lip and chin, diarrhoea and anxiety. All new symptoms I had never had before. Hence trips to gp who insisted cause anxiety. The rest of the story is on my signature, in short, two years of hell. As you can see on my signature came off the inhaler for a non steroid one after endocrinologist pointed out it could be a problem. Found out my symptoms were caused by the inhaler which presumably I had become sensitive to after the poop from citaloprom. If the gp had bothered looking up the side effect of these inhalers on the first visit he would have known straight away instead ended up on cipralex which has given me hell for two years .

Since then if I get chest infections any antibiotic reacts very badly, reduced to only one being able to being used. Chocolate doesn't seem to do me any good. The last private gp I saw while trying to work out what was going on with me prescribed beta blockers to try and slow everything down and second day my blood pressure flew to 210/ 101.  Came off them fast.  

 

I tried 500mg of vitamin c before bed and again in the morning earlier this week to try and calm the anxiety which is crippling while reinstating cipralex at the lowest dose for it to make everything worse including diarrhoea. Probably a stupid thing to do until i can balance from from the reinstatement but just desperate. 

 

Can anyone give me advice from their own experiences if this sensitivity will ever go away or is it something else I'm stuck with? 

 

 

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Gumtree

Admin - Please move post if not in the right place.

 

I've heard of "kindling" in terms of tapering and being sensitive to changes but not quite sure what it relates to (sorry, brain fog). 

I take it to mean that the brain is fried and kindled when you've tried to come off several times.

My question is: does this sensitivity develop if you taper and reinstate, taper and reinstate (like go up and down in doses) OR does it occur each time you drop doses?  The reason is, I have had a rough trot so have held this dose for three months now and am starting to feel better so i will consider anoth small percentage drop soon.  I wondered though if starting again would set off the kindling phenomenon and it would feel worse for me.  Sorry for the ramble but its been such a horror time and im starting to feel better.  I couldnt bear it getting worse than it has been, im not sure i can go through that.  

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Oran

Hi everyone, 

 

In November 2016 I took my last pill of effexor after a relatively fast taper. After one month of bad withdrawal symtoms I started to stabilize and feel remarkably better. On new years, however, I drank  two glasses of champagne, not knowing what the consequences would be. One week after that, I started to feel worse again, slowly regressing back into severe withdrawal. 9 months has now passed and I am feeling worse than ever, with symtoms still getting worse by every day. 

 

So.. My question is, do people recover from "kindling"  in withdrawal? - because that's what suppose those glasses of champagne did to me -  or am I doomed? 

 

I would appreciate a straight and honest answer. I am in great agony and would like to know what I can expect from the future. 

 

Thank you all, 

 

Kindest regards / Imad 

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UnfoldingSky

I haven't much time to talk right now but yes, you can recover.  I started and stopped Celexa a number of times each time getting a worse reaction, THEN cold turkeyed it, then added more drugs that did damage and most of my symptoms are now gone.

 

 

 

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UnfoldingSky

Also, as you only had a few glasses of champagne and I took years of pills after my reactions, you are in a better position than I was to recover.

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Oran
On 2017-09-29 at 10:27 AM, UnfoldingSky said:

Also, as you only had a few glasses of champagne and I took years of pills after my reactions, you are in a better position than I was to recover.

Thank you so much for replying UnfoldingSky. I'm glad to hear that you have recovered and thank you for giving me hope by sharing your story! Very kind of you! 

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Bluebird2009
On 05/03/2017 at 7:29 AM, Cherry47 said:

I was on ZOLOFT for 15 years and after about 10 years I started reacting to other medications and supplements, but of course everything was blamed except the a/d. One GP told me that I had only a certain number of enzymes in my liver to help absorb these things and that I had used all mine up, so that it was like overdosing! (Or some such crap)

 

I am two years out from going cold turkey, still very sick and cannot tolerate ANY meds or supplements, not even a low dose of paracetamol, I cannot rub fungal cream or cold sore cream onto my skin, foods finally not too bad.

 

A (very bad swear word) nightmare, that's for sure!

Do you think the adrenal dysfunction is what causes this? I read that when adrenals are not working to full capacity we react to meds and supplements. Any ideas

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UnfoldingSky

No problem, I hope your recovery goes well!  And I love your owl photo by the way!

 

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spidey

Let me start out by saying that I realize no one will have an actual answer for me on this one. Regardless, I do appreciate any opinions others may want to give.

 

My nervous system has been running itself into the ground for years with it's beyond ridiculous reactions to simple everyday things. Everything is a threat it would seem. Temperature changes that are too abrupt, such as when I emerge from the shower, will induce agitation, exhaustion, and a general "wigged out" feeling. Eating is unacceptable to my system, apparently, along with light, sound, social interactions, driving (longer than an hour and I am out of it for the rest of the day), reading, and sleeping (this is heavily protested for some reason).

 

Things improve slightly if I avoid socializing, only expose myself to natural light, severely limit time listening to music or watching t.v./youtube videos, slowly go about activities and rest in between "sets," and eat as little as possible. If I keep this going I know a bit of peace for a time. The very second that I need to interact, run an errand, what have you...I'm right back in the horror show. Feels as though an electric fence has been put up between me and living now. I have more hope and enthusiasm for moving forward when I convince myself that however long this has been going on, it can still be thought of as temporary. That all I need do is calm my nerves and my brain and body will regain their tolerance to stress. This feels more often like wishful thinking, though. Deep down I am more convinced that this is the way I am now, and nothing that I do will change it. I can hold off stress (or what's seen as stress, rather), attempt to avoid it, but I will never again be able to withstand it.

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StarChild

Dearest Spidey

 

Thank you for sharing this very frustrating, exhausting and debilitating suffering.

 

While I am not hypersensitive as you have described it here, I am an HSP. I struggle with sensitivity to everything that is required for ordinary functioning in my career - caffeine, social interactions, critical feedback (even if its constructive). It is very hard to be in a competitive environment with these sensitivities. This is compounded by OCD, Anxiety, Depression and my love-hate relationship with my meds which I have to come to accept that I need.

 

It is really painful and I wish you much strength and courage in facing the daily battle that you have to face each day.

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spidey

Thank you responding and for sharing your experience with me, StarChild. :) It is comforting to hear that others out there, at least to some degree, struggle with this as well.

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Cherry47

I found this article written by Charles Lapp, MD, of Hunter-Hopkins Center, Duke University who says “Some anti-depressants can also affect the cytochrome P450 system, which detoxifies the liver.  If that system is blocked by the drug, other medications cannot be metabolised and build up in the body, leading to a higher risk of adverse effects.”

 

This was in an article he wrote about using antidepressants to treat Chronic Fatigue Syndrome (which is why I was given the drug).  I guess this is what my doctor was saying but he had no idea the antidepressants were the cause of the problem.

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AlaskanGlacier

I could have written this same exact thread, post :( Right there with you. I feel the same way. Exercise, food, social interactions, simple every day things make my nervous system feel like it's broken.. although it has been improving, it's taking so long it feels permanent :( Sorry. Hang on. Other people who heal from antidepressants/benzos/etc say they felt the same way and it got better. 

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Lakelander82

I have a significant problem with this also in terms of social interactions, sudden sounds etc although I don’t seem to be as sensitive as some people as exercise or changes in light don’t exascerbate my symptoms. 

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Spruce30

I have been left with a lot of allergies and  sensitivities to things in my environment, which I never had before taking these drugs, and which started just after stopping them. I hope it all goes away eventually.

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Altostrata

I have found the hypersensitivity reduced. Didn't go away, but greatly reduced.

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Spruce30

Can i ask what things you are hypersensitive to altostrata?

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JamesF

Hi Spidey,

 

Sorry to hear of your suffering.

 

Just wanted to say that I've got in and out of extreme hypersensitivity several times. My first unsuccessful tapering lead to very generalised hypersensitivity as you describe. I was often unable to get in the shower, it was simply too much sensory overload. The most minor stressors made me crash. Something surprising or emotional on TV would make me crash for hours. Walking a few hundred meters too far made me crash for days. I had to finely regulate every single aspect of life just to survive. It felt like extreme chronic fatigue mixed with the hypersensitivity of withdrawal. 

 

After I reintroduced another SSRI, it did go away in large part. Maybe 75%. Although certainly not completely. After the first big withdrawal crash I was never again able to tolerate caffeine, alcohol, moderate physical exercise, intense heat and other big changes in equilibrium. But most of these big changes were unhealthy anyway. So in a way it led to more healthy habits and much more gentleness towards myself. No more burning myself out with work or exercise, or any other extremes I used to indulge in.

 

Finding this kind of kindness towards oneself is very healthy. Even if it  essentially came through being defeated and not having a choice.

 

Later on I had another withdrawal disaster (4 months ago) and went back to extreme hypersensitivity to everything. I had to hide in my room from light , noise, temperature changes, any stimuli or exertion physical mental emotional or otherwise. Things have only started to reverse since I reinstated. I'm perhaps 40% better than I was 2 months ago now. So I am hopeful of returning to significantly less sensitive. The CNS simply takes a long time to heal.

 

Unfortunately things only ever got worse when I was totally off the meds, so I can't speak to healing from hypersensitivity in protracted withdrawal, only in reinstatement. 

 

Anyway, just wanted to comment since I'm someone who has experience extremes of these symptoms, come back (mostly), gone there again, and is now hopefully coming back again.

 

Wishing you the best, Jay

 

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