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Notme: How to taper sertraline


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I have been on Sertraline (Zoloft)  50 mg for 5 months. I want off due to a side effect. So went down to 25 mg for the past 5 days. What now, because they are capsules I can't split them and this is the smallest dose. Can anyone offer advice, doctors have not been very helpful. Thanks

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  • Moderator Emeritus

Welcome to SA, Notme.  It's not surprising your doctor has been of little help, as they know nothing about safe tapering or antidepressant withdrawal.


We recommend tapering by no more than 10% of current dose every four weeks.




Since you tapered by 50%, which is much higher than we recommend, it is possible that you may experience withdrawal symptoms.  How are you feeling?  


I would hold where you are for at least a month to make sure you don't experience withdrawal symptoms.  If they do develop and are severe, it may be necessary to updose (increase your dose) by a small amount.  
There are several ways to obtain the small non-standard doses you will need for a 10% taper. The best way is to use liquid Sertraline.  Find out from a pharmacy if liquid Sertraline is available in Canada.  Another way is to open the capsule and weigh a  10% decrease of the powder.  Many members here use the AWS Gemini-20 scale available from Amazon.

Or you can have a compounding pharmacy make your doses.  


Details are in the following link:


Tips for tapering off Zoloft (sertraline)


This is your Introduction topic, where you can ask questions and connect with other members.  We're glad you found your way here.






Gridley Introduction


Lexapro 20 mg since 2004.  Begin Brassmonkey Slide Taper Jan. 2017.   

End 2017 year 1 of taper at 9.25mg 

End 2018 year 2 of taper at 4.1mg

End 2019 year 3 of taper at 1.0mg  

Oct. 30, 2020  Jump to zero from 0.025mg.  Current dose: 0.000mg

3 year, 10 month taper is 100% complete.


Ativan 1 mg to 1.875mg 1986-2020, two CT's and reinstatements

Nov. 2020, 7-week Ativan-Valium crossover to 18.75mg Valium

Feb. 2021, begin 10%/4 week taper of 18.75mg Valium 

End 2021  year 1 of Valium taper at 6mg

End 2022 year 2 of Valium taper at 2.75mg 

End 2023 year 3 of Valium taper at 1mg

Jan. 24, 2024: Hold at 1mg and shift to Imipramine taper.

Taper is 95% complete.


Imipramine 75 mg daily since 1986.  Jan.-Sept. 2016 tapered to 14.4mg  

March 22, 2022: Begin 10%/4 week taper

Aug. 5, 2022: hold at 9.5mg and shift to Valium taper

Jan. 24, 2024: Resume Imipramine taper.  Current dose as of April 1: 6.8mg

Taper is 91% complete.  


Supplements: multiple, quercetin, omega-3, vitamins C, E and D3, magnesium glycinate, probiotics, zinc, melatonin .3mg, iron, serrapeptase, nattokinase

I am not a medical professional and this is not medical advice but simply information based on my own experience, as well as other members who have survived these drugs.

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Hello @Notme, nice to meet you.


I have been tapering sertraline for a long while. I'm also doing it for side effect reasons. Happily for me they are dose related and I am at the point where they're not noticeable.


How are you feeling?

2005 St John's Wort / 2006-2012 Lexapro 20mg, 2 failed attempts to stop, tapered over 4.5 months in early 2012

January 2013 started Sertraline, over time worked up to 100mg

July 2014 Sertraline dropped from 100mg to 75mg, held for six months, slower tapering until 2019 22 Dec 3.2mg

2020 Sertraline 19 Jan 3.1mg, 26 Jan 3.0mg; 1 Mar 2.9, 7 Mar 2.8, May (some drops here) 24 May 2.5, May 29 2.4, June 21 2.3, June 28 2.2mg,  July 4 2.1mg, July 24 (or maybe a bit before) 2mg, early Nov switched to home made suspension; 29 Nov 1.8mg; approx 25 Dec 1.6mg)

2021 Some time in about Jan/Feb realised probably on more like 1.8mg and poss mixing error in making suspension; doses after 10 Feb accurate; 10 Feb 1.6mg; 7 Mar 1.4, continued monthly

10% drops until 1mg, then dropped 0.1mg monthly.

May 2022,0.1mg, now dropping 0.01mg per week

29 August 2022 - first day of zero!

My thread here at SA: https://www.survivingantidepressants.org/topic/1775-bubbles/page/21/

Current: Armour Thyroid



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Thank you for the welcome. 

I reduced to 25 mg 6 days ago and so far have felt no difference. Since I started taking Sertraline almost 5 months ago, I have not noticed much improvement in depression though it seems to help a bit with anxiety. My main issue is I've gained weight from being on it. That is a common side effect but being overweight isn't something that's going to help my depression. 

Would like to go off a bit more aggressively than 10% and would like to hopefully just taper off the 25 mg dose. And yeah, you're right, not much help from doctors. A pharmacy I phoned suggested take 25 mg every other day for a week then quit...but it's all just a guess. Thanks also for the links

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  • Administrator

Welcome, Notme.


Please do NOT skip doses of any psychiatric drug to taper. We see terrible withdrawal symptoms from this.


Sertraline comes in a liquid form for convenient tapering. Are you able to get this through your doctor? Otherwise, you can make your own liquid. Please read 

Tips for tapering off Zoloft (sertraline)


We recommend a very gradual taper to avoid withdrawal symptoms which, once they get started, can make you feel miserable for a very long time. Strongly suggest you start on a slow, gradual taper to see what your tolerance is for dosage reduction. The first reduction often goes easier because the drugs are so strong, but you might feel reductions more on a lower dosage.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

All postings © copyrighted.

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  • ChessieCat changed the title to Notme: How to taper sertraline

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