Malingos Posted April 17, 2022 Posted April 17, 2022 Hello. I’ve been taking Fluox 40mg for a number of years. Want to come off - emotional coldness / lack of feeling ‘emotionally sober’ is causing me problems in my personal life. Spoke to my doc, dropped me to 30mg. Obviously; this is more than the general consensus here of 10%. However, my reading of Horowitz makes me believe this is not likely to be an issue as the intake vs. Impact at receptor level is non linear. I.e. the drop from 10 to 8mg has way more impact that the drop from 40 to 30mg. As such, I was wondering if anyone had any experience of tapering at higher rates to start and then moving to lower tapering rates? I obviously want to do this as quickly as possible, but without risking major side effects. My thoughts (and what I suspect doc will prescribe) is 40->30->20->10. At which point I would then want to move to liquid (if available in the uk) and do the ten percent. Any thoughts / experiences? 6.5 years fluoxetine 40mg. Now dropped to 30mg. some tricyclics before that.
Moderator Emeritus getofflex Posted April 18, 2022 Moderator Emeritus Posted April 18, 2022 Hello, and welcome to SA. We are a volunteer-run community of people who have been or are getting off of psychiatric drugs. I'm glad you found us early in your taper. Have you had any symptoms since you dropped from 40 mg to 30 mg fluoxetine? If not, it's probably because these drugs are given to us at excessively high doses, and often reducing them at the higher doses has a small to no effect on our nervous systems. But, as we go down in dose, they have a bigger and bigger effect on us. What date did you reduce to 30 mg? Please add this to your drug signature. Have you been on any other drugs besides fluoxetine or tricycles? If so, please add this info to your drug signature. Here is some important information about how these drugs actually work. This explains why we get symptoms from going off of these medications, and why it's so important to taper slowly and carefully, and be very cautious about changing our doses: How Psychiatric Drugs Remodel Your Brain This helps you understand what withdrawal syndrome is: Video on Recovery from Psych Drugs Windows and Waves Pattern of Stabilization I can understand your being anxious about wanting to get off the drug quickly. A safer way to do this, is to go ahead do the conservative taper rate of 10% of the current dose every 4 weeks, and if you have no symptoms for a couple of reductions, you can do another reduction after 3 weeks, instead of 4. The link below will explain this. Once you have thrown your nervous system into chaos by tapering with big reductions, it can take months to years to recover from that, so rushing a taper is like playing Russian roulette with your brain. Some people get away with it, but for those who don't, it's very unpleasant, and takes a long time to recover from. Unfortunately, the vast majority of doctors taper people off psych meds way too fast, which is why this site exists. Tapering is best done extremely slowly, and we generally taper by 10% of the current dose no more than once every 4 weeks, so that the reduction becomes exponentially smaller. Why Taper by 10% of my Dosage Tips for Tapering off Fluoxetine (Prozac) Here is a link with checklists of common WD symptoms, just in case: Dr Joseph Glenmullen Withdrawal Symptom Checklists Here are some techniques to cope with symptoms: Non Drug Ways to Cope with Withdrawal Symptoms Stability is really important when we are tapering off psych meds. Please read the link about stability: Keep It Simple, Slow, and Stable We don't suggest many supplements, but 2 that many of us find helpful are magnesium and omega-3 fish oil. Here are the links for info about those. It is suggested to add one at a time, and start with a low dose to see how it affects you. Magnesium Omega 3 Fish Oil Please do not private message me. Only tag me for urgent questions about tapering and reinstating - thank you. ***Please note this is not medical advice. Discuss any decisions about your medical care with a doctor who understands psych meds and how to withdraw from them, if you can find one. Lexapro Started Apr 15 2010 - 10 mg; started taper August 2017, recent taper info: Apr 2 '20 0.18 mg; Jul 16 0.17 mg, Aug 23 0.16 mg, Oct 7 0.15 mg, Nov 8 - 0.14, Jan 16 '21 - 0.13, Feb 7 - 0.12, Feb 22 - 0.11, Mar 26 - 0.10, May 21 - 0.09, June 15 - 0.08 Aug 16 - 0.07, Oct 6 - 0.06, Nov 21 0.05, Dec. 17 0.04, Jan 14 '22 0.03, Feb 19 0.02, Apr 18 0.01, May 15 0.005, Jul 8, 0.00. Psych Drug Free as of July 8, 2022!! Woohoo!!! other meds: Levothyroxine 75 mg magnesium in small amounts at 4 AM, before bed suppl AM: fish oil, flax oil, vit C, vit E, multivitamin, zinc suppl 8 PM: magnesium 350 mg, extended release vitamin C, melatonin 2 mg Paxil 2002 - 2010, switched to Lexapro 2010 Trazodone 50 mg. 2002 - 2019, fast tapered in 2019 Xanax 0.5 mg as needed 2002 - 2019, up to 3x weekly
Mentor Faure Posted April 18, 2022 Mentor Posted April 18, 2022 Hello, my thoughts are to suggest you read some threads on here to see just how bad WD can get….I’d strongly recommend following Frogie’s advice of 10% every 4 weeks, decreasing to 3 if you don’t get WD effects. After about 3 failed attempts to get off myself and taking a year to stabilise after the final go I am now having great success with the BrassMonkey slide. Yes, it’s slow, but life has improved immensely already which gives me hope that things will continue to get better steadily and I have the best chance of staying well doing it this way. When life falls apart because of WD it takes far too long to get it back on track for me to want to take any risks. I’d also say consider this in your decision making ☺️ I am not a medical professional. I provide information and make suggestions based on my own experience and SA guidelines. I am unable to respond to private messages. Mirtazepine 15mg Nov 2018 -April 2019 April - Sept 2019 Mirtazepine down to around 6mg - skipping days to taper October 2019 - Dec 2019 unwell from failed taper including jumping about in doses 15 December 2019 to 13 June 2021 15mg Mirtazepine 14 June 2021 started brass monkey Slide. 2021: 23 August 12.3mg, 28 October 11.1mg, 6 Dec 10mg 2022: 12 Feb 8.5, 25 Oct 4.5mg 2023: 16 Jan 3.6mg, 28 Sept 1.8mg 2024: 13 May 1.1mg 2024: September reinstated 15mg owing to severe depression planning to stay on for the very long term
Malingos Posted April 18, 2022 Author Posted April 18, 2022 Thanks for the advice. Only a week into my 40->30 change. Will discuss getting on liquid for the next scrip to make the taper less of a faff 6.5 years fluoxetine 40mg. Now dropped to 30mg. some tricyclics before that.
Toast Posted April 19, 2022 Posted April 19, 2022 Hi @Malingos I was on prozac for 15 years (I guess 17 now since I’m still tapering). I would recommend following SA guidelines but I did just want to mention my own experience. I went from 40 mg to 10 mg over the course of a month. Then I held at 10 mg for a year. I experienced no withdrawal during this year. (The following year, when I tried to go to 10 mg to 0 mg, no taper, then I experienced severe withdrawal). I explain my experience according to the paper you mentioned by Horowitz, SERT blockade-wise, prozac has around the same magnitude effect on receptors at 40 mg as it does at 10 mg. That said, it is always better safe than sorry, so I wouldn’t necessarily recommend what I did, even though it gave me no problems. Please keep in mind too that fluoxetine has an active metabolite (norfluoxetine) and as such a very long half life of 10-14 days so you may not feel the effects of a change until a month later. My own experience was like descending into the depths of Hell, one step at a time. Would not recommend 2005 - Zoloft, 200 mg for childhood anxiety (starting at age 11) Summer 2015 - Switched to Prozac, 40 mg June 2019 - Tapered to 10 mg Prozac, no adverse effects. Held for 1 year. June 2020 - Discontinued Prozac. Horrible withdrawal. Did not realize it was withdrawal at first. Nov 2020 - Reinstated Prozac 2.5 mg. Still experiencing withdrawal symptoms. May 2021 - Prozac 2.0 mg. Still experiencing symptoms - some symptoms have improved, but situational factors have worsened. August 12 2021 - Prozac 2.25 mg. Partial reinstatement as symptoms had worsened June 17 2022 - Prozac 2.0 mg; Sept 13 2022 - Prozac 1.75 mg; Nov 1 2022 - Prozac 1.5 mg; Feb 1 2023 - Prozac 1.25 mg; Apr 1 2023 - Prozac 1.0 mg; June 15, 2023 - Prozac 0.75 mg; Aug 15, 2023 - Prozac 0.5 mg
Malingos Posted April 19, 2022 Author Posted April 19, 2022 Thank you for sharing, Toast. Still unsure as to what to do in 2.5 weeks when my 30mg scrip runs out. I have loads of 20s in stock. Will have to speak to my GP soon. 6.5 years fluoxetine 40mg. Now dropped to 30mg. some tricyclics before that.
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