Josef: Hello World, I need help.

[Josef]

Hey guys! Im 34 yo,

Im on amisulpride for the last 4.5 years and trying to get some information about withdrawal..but didnt find any evidence online that someone did withdrawal completly from 400mg or similar dose.

 

i've read one of the users topic, she calls herself Whitlly, but she didnt withdrawal completly from this medication

 

Today im on 400mg for at least a year.. 

My first question is how to taper off amisulpride? 

Do i need to scale it and mix it in water or something like this?

 

Big thanks in advance

[Altostrata]

Welcome, @Josef

 

Yes, you will need to taper amisulpride. Amisulpride may be available as a prescription liquid, which is the most convenient way to taper. You may wish to take half your daily dose in tablet form and half in liquid to start, then slowly taper the liquid by 10% per month or less, see Why taper by 10% of my dosage?

 

For your information, see Keks, N., Schwartz, D., & Hope, J. (2019). Stopping and switching antipsychotic drugs. Australian Prescriber, 42(5). https://doi.org/10.18773/austprescr.2019.052

 

[Josef]

In my country the soloution liquid is not available, how can i tapper it with the tab?

[Josef]

Oh and by the way, Did anyone ever wrote here about completing withdrawal from amisulpride? I wonder because i didnt find anyone on the net.. this drug ia about 20 years, but nobody wrote about it.. its fishy.

[Josef]

I started three days ago lowering the dose, current dose : 350mg

[Josef]

Im trying to understand what are my chances to get off this drug, i had an anxiety for 3 months then hospitilized myself, they gave me antipsychotics and said ny definition is scizoeffective 

[Josef]

When i had anxieties After months my parents didnt know what to with me, so we went to our GP and he gave me cipralex (an anti anxiety medication) that has completely made me anxious even more than what i was, than i gave up and got hospitilized.

[Josef]

Now im with this drug, amisulpride, that from what i know when you stop it makes you paranoid, delusional and sleepless

[Josef]

Back in 2018 i did try not taking it (from 200mg to zero). advised by the local

Hospital psychiatrist..(sorry for the language, but what a dumbass).

Anyway i did not take the pill for half a year, and as they all say.. it was horrible! I had Paranoia attacks- daily. I had Anxiety- weekly, very powerful delusions by the hour and of course insomnia.

 

All of those symptoms are may be withdrawal symptoms, but than again we dont have an online or any official evidence that one could make a withdrawal from high dosage of amisulpride.

Then i consider it as a prominently brain damaging drug (because i didnt had paranoia before, or hard delusions such as this.)

 

I have lost my job as a sound engineerer and as a concert manager while withdrawing. After half a year i just gave up and hospitalised, than got back on amisulpride.

 

Today i am more stable but still have thoughts on this drug dependency as the time goes by.

 

Im planning on reducing this so called 'medicine' to the bare minimum, and maybe in the future we will have some more information about how to quit.

stay positive all of you who's taking amisulpride. Be safe for now

[Josef]

Hey again,

if anyone had an experience with this medicine from a high dosage and did quit or switched to another drug  successfully please feel free to share.

 

in the past two months i did a research  online on if people, or even one person, did withdrawal from amisulpride.b

but the facts are is that no one withdrawaled from it and it is a very bad news 

I really dont know what to do or what to think anymore. Please advise me

[Josef]

And Silence has spoken.

[Josef]

Reduced my dose to 300mg in 14th of may.

Ill reduce my dose to the bare minimum and still function/work.

 

 

 

 

 

[Josef]

Hey guys its Joseph, im 34 yo in the next month and I'm taking an antipsycotic (solian/amisulpride) for 4.7 years.(current dose : 300mg)

 

After a long research I've came to the conclusion that there's not enough information about anyone who did a complete wd from amisulpride. Maybe because it's a less common med.

 

Some facts: People, like me, who was on this med for long term of use and was on high dosages (800mg and above) felt very unstable with lower doses (under 200/150/100mg). 

 

And so i was reading about the mechanism of amisulpride that appears to be work as dopamine antagonist from 200/400mg and above, but acts as dopamine agonist in low doses (very dopaminergic). So maybe because of that reason it makes the wd process very difficult.

 

Therefore, I want to switch to another antipsycotic medication with a parallel dosages to what im taking today (which Im very scared of) and have findings about people who do came off

 

What are your thoughts about it?

And did anyone has made this meds switch before?

What are your recommendations?

 

Btw

I went cold turkey after 1.5 years of use, it didn't went well, after half a year i was on it once again, today I'm willing to try the 10% reduction technique

 

Thanks in advance

Joseph.

 

 

 

Edited May 30, 2021 by Gridley

[Gridley]

Welcome to SA, Josef.  Thank you for completing your drug signature.

 

We are a site for tapering psychiatric drugs and helping members deal with withdrawal from these drugs.

 

Changing to an equivalent antipsychotic is outside the scope of what we do here.  This should be discussed with your doctor.

 

If you want to taper Amisulpride, we recommend tapering by no more than 10% of your current dose every four weeks.  We don't recommend cold turkey off psychiatric drugs.

 

Why taper by 10% of my dosage?

 

Amisulpride and Risperdal and different drugs but are often prescribed for the same diagnosis.  Here's our link on tapering Risperdal, which may in part be applicable to tapering Amisulpride, including how to get the non-standard doses needed for a 10% taper.

 

Tips for tapering off risperidone (Risperdal)

 

We have a number of success stories of members who've gone off Risperdal.  Here's one:

 

risperdalhater I recovered from risperdal aka risperidone ...

 

For more Risperdal success stories, please Google SurvivingAntidepressants.org Risperdal success stories.

 

We don't recommend a lot of supplements on SA, as many members report being sensitive to them due to our over-reactive nervous systems, but two supplements that we do recommend are magnesium and omega 3 (fish oil). Many people find these to be calming to the nervous system. 

 

Magnesium, nature's calcium channel blocker 

 

Omega-3 fatty acids (fish oil) 

 

Add in one at a time and at a low dose in case you do experience problems. Get supplements that are single ingredient (not mixed with other types of supplements).

 

This is your Introduction topic, where you can ask questions and connect with other members.  We're glad you found your way here.

 

 

 

 

[Josef]

2 hours ago, Gridley said:

Welcome to SA, Josef.  Thank you for completing your drug signature.

 

We are a site for tapering psychiatric drugs and helping members deal with withdrawal from these drugs.

 

Changing to an equivalent antipsychotic is outside the scope of what we do here.  This should be discussed with your doctor.

 

If you want to taper Amisulpride, we recommend tapering by no more than 10% of your current dose every four weeks.  We don't recommend cold turkey off psychiatric drugs.

 

Why taper by 10% of my dosage?

 

Amisulpride and Risperdal and different drugs but are often prescribed for the same diagnosis.  Here's our link on tapering Risperdal, which may in part be applicable to tapering Amisulpride, including how to get the non-standard doses needed for a 10% taper.

 

Tips for tapering off risperidone (Risperdal)

 

We have a number of success stories of members who've gone off Risperdal.  Here's one:

 

risperdalhater I recovered from risperdal aka risperidone ...

 

For more Risperdal success stories, please Google SurvivingAntidepressants.org Risperdal success stories.

 

We don't recommend a lot of supplements on SA, as many members report being sensitive to them due to our over-reactive nervous systems, but two supplements that we do recommend are magnesium and omega 3 (fish oil). Many people find these to be calming to the nervous system. 

 

Magnesium, nature's calcium channel blocker 

 

Omega-3 fatty acids (fish oil) 

 

Add in one at a time and at a low dose in case you do experience problems. Get supplements that are single ingredient (not mixed with other types of supplements).

 

This is your Introduction topic, where you can ask questions and connect with other members.  We're glad you found your way here.

 

 

 

 

Thank you so much for your reply,links and recommendations Gridley!

 

My intentions are to reduce to the bare minimum dose as possible.

Sure I want to come off my meds. Yes. 

 

But risperidal is just not the same as the med I'm taking  solian.

Whice as I stated before has a different mechanism of action in lower doses. Very dopaminergic, very stimulant. A dosage of 12.5/25mg acts as an antidepressant and some psychiatrists do prescribe it to people who have issues with depression.

 

I have researched my med in forums, sites and databases for 3 months straight.

And my conclusion is there's just not enough info about people who tried to lower their dose.

 

That is why I'm sharing with you my dillema, which is about tapering, about helping and about withdrawal.

 

My dillema is will it be wise to switch to other med (with an equivalent dose) and then start off? Will it be more effective and less hard withdrawal symptoma with other med due to the fact solian acts also as a stimulant in low dosage? This is a very serious thing here and I believe that has nothing to do with my psychiatrist..unless you can address me with any reason Gridley.

 

Anyway, any suggestion or an open minded advice/reply would be really appreciated (very much!!)

Thanks in advance you guys!

 

 

[Gridley]

2 hours ago, Josef said:

 

My dillema is will it be wise to switch to other med (with an equivalent dose) and then start off? Will it be more effective and less hard withdrawal symptoma with other med due to the fact solian acts also as a stimulant in low dosage? This is a very serious thing here and I believe that has nothing to do with my psychiatrist..unless you can address me with any reason Gridley.

Josef, I understand your dilemma.  I don't have an answer.  I have brought your situation to the attention of the other staff.

[Altostrata]

3 hours ago, Josef said:

My intentions are to reduce to the bare minimum dose as possible.

 

Hello, @Josef

 

You've done a good job going down to 300mg. Did you have any problems in reducing amulsipride?

 

We have a few people here tapering amulsipride, put "amulsipride" in the search box at the top of the page to find their stories.

 

We advise a very careful taper of no more than 10% per month for amulsipride, which comes in prescription liquid form for titration. This is a good way to get to minimal effective dose, you would observe your symptoms carefully for a month to make sure they don't get so bad, you'll have to go to the hospital, where you're likely to get even higher doses of more drugs.

 

It appears amulsipride comes in 50mg, 100mg, and 200mg tablets. Since you're taking 300mg, what you might do is get your prescription filled with 200mg tablets and 100mg liquid amulsipride per day. Then you can gradually reduce the liquid portion by 10% of the total day dosage. The first reduction would be 30mg (10% of 300mg), so you'd be taking one 200mg tablet and 70mg in liquid form per day for a month to see how you do.

 

The next reduction would be 10% of 270mg, or 27mg subtracted from the 70mg liquid, resulting in one 200mg tablet and 43mg in liquid form per day for a month. And so forth. When you get below 200mg, you'd switch to a prescription filled with 100mg tablets and 100mg liquid amulsipride per day, then continue to reduce from the liquid portion.

 

Risperidone, etc. is not any easier to taper. We do not coach people in drug switches if they intend to stay on drugs, that's your doctor's job.

[Josef]

5 hours ago, Altostrata said:

 

Hello, @Josef

 

You've done a good job going down to 300mg. Did you have any problems in reducing amulsipride?

 

We have a few people here tapering amulsipride, put "amulsipride" in the search box at the top of the page to find their stories.

 

We advise a very careful taper of no more than 10% per month for amulsipride, which comes in prescription liquid form for titration. This is a good way to get to minimal effective dose, you would observe your symptoms carefully for a month to make sure they don't get so bad, you'll have to go to the hospital, where you're likely to get even higher doses of more drugs.

 

It appears amulsipride comes in 50mg, 100mg, and 200mg tablets. Since you're taking 300mg, what you might do is get your prescription filled with 200mg tablets and 100mg liquid amulsipride per day. Then you can gradually reduce the liquid portion by 10% of the total day dosage. The first reduction would be 30mg (10% of 300mg), so you'd be taking one 200mg tablet and 70mg in liquid form per day for a month to see how you do.

 

The next reduction would be 10% of 270mg, or 27mg subtracted from the 70mg liquid, resulting in one 200mg tablet and 43mg in liquid form per day for a month. And so forth. When you get below 200mg, you'd switch to a prescription filled with 100mg tablets and 100mg liquid amulsipride per day, then continue to reduce from the liquid portion.

 

Risperidone, etc. is not any easier to taper. We do not coach people in drug switches if they intend to stay on drugs, that's your doctor's job.

Hey Altostrata! Thank you for your reply,

I didn't had any symptoms until now, I know I'll be OK until i hit 200mg.

 

I dont have it available in liquid form in my country.

 

I'm NOT trying to switch to another drug and intend to stay on them.

 

I'll say it again (third time),

The mechanism of amisulpride works in low doses also as a stimulant, it is prescribed as an antidepressant in low doses such as 12.5/25/50mg in many countries by psychiatrists.

 

I believe that's the reason why people couldn't come off of it at all or could not make even a slight dose reduction from 200mg because of its stimulant/dopamine agonist and antipsychotic effect.

 

So, Would it be wise to switch it with other antipsycotic (perhaps with a longer half life) due to its stimulant effect and then continue with the withdrawal process? Any open minded opinion would be very welcomed. Thanks

 

[Josef]

6 hours ago, Gridley said:

Josef, I understand your dilemma.  I don't have an answer.  I have brought your situation to the attention of the other staff.

Thank you very much Gridley!

[Shep]

10 hours ago, Josef said:

The mechanism of amisulpride works in low doses also as a stimulant, it is prescribed as an antidepressant in low doses such as 12.5/25/50mg in many countries by psychiatrists.

 

I believe that's the reason why people couldn't come off of it at all or could not make even a slight dose reduction from 200mg because of its stimulant/dopamine agonist and antipsychotic effect.

 

 

Josef, yes, you're right about this. I found this research which goes into how this drug works:

 

Amisulpride - Mechanism of Action

 

 

10 hours ago, Josef said:

So, Would it be wise to switch it with other antipsycotic (perhaps with a longer half life) due to its stimulant effect and then continue with the withdrawal process? Any open minded opinion would be very welcomed. Thanks

 

Before you make any more reductions or changes to another drug, please give the staff some time to sort this out, as this isn't a very common drug. Since you've already spent time researching, please feel free to post links regarding this drug.  We welcome building up a knowledge base for all of these drugs. 

 

You can post links here in your Intro / Update thread, and we also have a section of the forum reserved for Journal and Scientific Sources. 

 

Do you have a history of taking any other psychiatric drugs in the past? Is this the first and only antipsychotic you've been on? If you've been on other psychiatric drugs, especially antipsychotics, please give us more information about your experiences. 

 

Also, are you having any withdrawal symptoms so far? If so, please let us know what they are and if possible, if they correlated to any specific dose reductions. 

[Shep]

@JosefJust a heads up that I saw you had an earlier Intro thread from April, so I merged it in with this current thread. Now all of your information is in one place. 

[Josef]

5 hours ago, Shep said:

 

Josef, yes, you're right about this. I found this research which goes into how this drug works:

 

Amisulpride - Mechanism of Action

 

 

 

Before you make any more reductions or changes to another drug, please give the staff some time to sort this out, as this isn't a very common drug. Since you've already spent time researching, please feel free to post links regarding this drug.  We welcome building up a knowledge base for all of these drugs. 

 

You can post links here in your Intro / Update thread, and we also have a section of the forum reserved for Journal and Scientific Sources. 

 

Do you have a history of taking any other psychiatric drugs in the past? Is this the first and only antipsychotic you've been on? If you've been on other psychiatric drugs, especially antipsychotics, please give us more information about your experiences. 

 

Also, are you having any withdrawal symptoms so far? If so, please let us know what they are and if possible, if they correlated to any specific dose reductions. 

Hey Shep! Thank you very much for taking the time, your feedback is so important to me, you dont know how much!

I didnt save any of the web sites, but if I'll have further information about this drug I'll let you know.

 

I didn't take any other antipsychotic rather than amisulpride. It's the first and the only drug I have taken.

 

Hmm No symptoms, so far so good! 

 

I'll share my thoughts on this..

so let me know what you think.

 

My thoughts were to try wd straight away with amisulpride, and dealing as much as i can in lower doses (200mg and downward).

if I'll be in a bad situation, such as upping and lowering the dose over and over for two months or so, because of over-stimulantion, antidepressant-like effect so I'll make the switch to another ap drug  with an equivalent dose.. perhaps risperidal?

 

That way i can try and make my best efforts to reduce below 200mg only with amisulpride, if I'll make a big or a small progress.

And as for switching my medication -it will be lesser of a dose (instead of an equivalent dose of 200mg to start with.).

So other dopamine/serotonin receptors that are related to the new med will be less affected (less overall damage?)

 

Tell me what do you think?

 

[Josef]

LDA (Low dose of Amisulpride)- PUBMED

[Shep]

17 hours ago, Josef said:

Hmm No symptoms, so far so good! 

 

Excellent to read, Josef. Starting off a taper without symptoms puts you in a very good position. 

 

17 hours ago, Josef said:

And as for switching my medication -it will be lesser of a dose (instead of an equivalent dose of 200mg to start with.).

So other dopamine/serotonin receptors that are related to the new med will be less affected (less overall damage?)

 

When doing a crossover, you would try to keep the dose as equivalent as possible. If you aim for a lessor dose, you won't know if any symptoms arose due to the decrease of dose or the change of drug. 

 

Here is a chart that lists equivalencies. See the first post in this thread: 

 

Dose Equivalents / Equivalency for Antidepressants and Second-Generation Antipsychotics

 

Will your doctor work with you to prescribe what you need if you decide to do a crossover to another drug? 

 

It's likely you are physically dependent on Amisulpride, so crossovers contain the risk of withdrawal symptoms even when crossing over. 

 

1 hour ago, Josef said:

LDA (Low dose of Amisulpride)- PUBMED

 

 

Thanks for posting the article. Please let us know the parts of the research that pertain to your situation. Are you afraid of developing hyperprolactinemia as you taper and reach lower doses? That study involved people dealing with polypharmacy and taking other psychiatric drugs (amisulpride was used as an augmentation therapy). So that risk doesn't apply to you since you're only on this one drug. 

 

[Josef]

1 hour ago, Shep said:

Excellent to read, Josef. Starting off a taper without symptoms puts you in a very good position. 

Well, I'm still young i guess? ^^

 

1 hour ago, Shep said:

If you aim for a lessor dose, you won't know if any symptoms arose due to the decrease of dose or the change of drug. 

I understand, the chart may be very useful to me in the future. Thank you for bringing this to my attention

 

1 hour ago, Shep said:

Will your doctor work with you to prescribe what you need if you decide to do a crossover to another drug? 

 

crossovers contain the risk of withdrawal symptoms even when crossing over

Yes. He wants to help me in any way as he possibly can

 

1 hour ago, Shep said:

crossovers contain the risk of withdrawal symptoms even when crossing over. 

Yes, I'm aware of that. Should I crossover when I'm reaching 200mg and more stable? Or continuing with the reduction process and then make the decision to crossover or not as i go? What would you do if you were in my shoes? Amisulpride is very risky in low doses and it might complicate my withdrawal process.

 

1 hour ago, Shep said:

Please let us know the parts of the research that pertain to your situation. Are you afraid of developing hyperprolactinemia as you taper and reach lower doses? That study involved people dealing with polypharmacy and taking other psychiatric drugs (amisulpride was used as an augmentation therapy). So that risk doesn't apply to you since you're only on this one drug. 

I actually have very high prolactin levels, Three and a half times more than normal and having severe side effects, so i might already have hyperprolactinemia (I'm seeing a neurologist next week).

My prolactin It's still going up from time to time, regardless of dosage.

 

There are dozens of posts on Reddit about people who prescribed only with LDA for major depression.

I presume that it's not only a poly/augmentational treatment.

The article support the fact that amisulpride acts as an antidepressant in lower doses.

 

[Altostrata]

Every drug switch has a risk that it will cause withdrawal symptoms or other adverse effects. I would not make a switch now. I would proceed with careful tapering and see how you feel when you get closer to 200mg.

 

Elevated prolactin levels are a recognized hazard of amisulpride and other antipsychotics.

 

16 hours ago, Josef said:

There are dozens of posts on Reddit about people who prescribed only with LDA for major depression.

 

An antidepressant is not necessarily stimulating. Simply because amisulpride is prescribed as an antidepressant doesn't mean it works.

 

I'm trying to verify your theory that lower doses are activating.

[Josef]

 

10 hours ago, Altostrata said:

Every drug switch has a risk that it will cause withdrawal symptoms or other adverse effects. I would not make a switch now. I would proceed with careful tapering and see how you feel when you get closer to 200mg.

I am aware there might be consequences. switching meds is a risk that I might take if it's based on statistics and facts that may facilitate my overall withdrawal.

I'll make an update when 200mg dose is reached.

 

10 hours ago, Altostrata said:

An antidepressant is not necessarily stimulating.

So what antidepressant feels like generally?

 

10 hours ago, Altostrata said:

I'm trying to verify your theory that lower doses are activating.

I'll appreciate it very much Altostrata!

[Shep]

Josef, are you sensitive to coffee or drugs or supplements that increase dopamine? The reason I'm asking is because of the possibility that Amisulpride facilitates the release of dopamine in those lower doses. 

Edited June 3, 2021 by Shep
added more information

[Josef]

Another thing to consider is the short half life of amisulpride, only 12 hours.

perhaps it's another reason why people can't withdrawal? Another reason to switch meds?

I presume when you're on withdrawal longer half life means less problems then short life.

 

Are there any other antipsychotics that have the same half life (12 hours) as amisulpride? and did a successfully withdrawal?

[Shep]

@JosefWe just posted at the same time. Please be sure to see my last post. 

 

 

5 minutes ago, Josef said:

I presume when you're on withdrawal longer half life means less problems then short life.

 

Are there any other antipsychotics that have the same half life (12 hours) as amisulpride? and did a successfully withdrawal?

 

If a drug has a short half-life, than you can split the dose and take it more than once a day. From my experience of with coming off antipsychotics and from what I've seen on the various withdrawal forums, the speed of the taper seems to be more related to the severity of symptoms. Going slow is the most important thing, not the half life, especially if you split the dose if needed for shorter half-lives. 

[Josef]

1 minute ago, Shep said:

Josef, are you sensitive to coffee or drugs or supplements that increase dopamine? The reason I'm asking is because of the possibility that Amisulpride facilitates the release of dopamine in those lower doses. 

I'm not using any drugs, i did get anxious here and there when i was smoking marijuana daily. (I was also an LSD user for two years, it was 12 years ago)

Today Im smoking only cigarettes, three light cups of coffee in a day or so, without any sensitivity issues so far.

[Josef]

6 minutes ago, Shep said:

@JosefWe just posted at the same time. Please be sure to see my last post. 

 

 

 

If a drug has a short half-life, than you can split the dose and take it more than once a day. From my experience of with coming off antipsychotics and from what I've seen on the various withdrawal forums, the speed of the taper seems to be more related to the severity of symptoms. Going slow is the most important thing, not the half life, especially if you split the dose if needed for shorter half-lives. 

Thank you Shep for your fast reply, and sure, will taper very slow. Got it.

Are there other ap's with that low half life as amisulpride? and people who do come off of? Thanks in advance.

[Shep]

1 hour ago, Josef said:

Today Im smoking only cigarettes, three light cups of coffee in a day or so, without any sensitivity issues so far.

 

When did you start smoking? Also, have you noticed the need to increase your coffee use or cigarette use while on amisulpride?

 

The reason I'm asking is because of the relationship of increasing dopamine with these other substances in order to counteract the dopamine decrease caused by the antipsychotic. For more, see:

 

Pubmed: Smoking and schizophrenia

 

It's possible you may be able to taper off some of the cigarettes and coffee, thereby lowering your dopamine, as you decrease the amisulpride in the lower doses where dopamine increase occurs.

 

This is just a theory, though, and something to research and think about.  Please go slowly and let us know how you're doing along the way. 

[Josef]

5 hours ago, Shep said:

When did you start smoking?

I started 14 years ago.

 

5 hours ago, Shep said:

Also, have you noticed the need to increase your coffee use or cigarette use while on amisulpride?

Yes, I used to smoke 12/13 cigs before amisulpride, today I'm smoking a full pack (20), if not more.. so the article makes sense.

.

It's also true for the caffeine, but reduced it from 7/8 heavy cups a day to 3 very light cups (and i cut the sugar). After a week the headaches and tension did not late to come.

 

So anyway.. If quitting cigarettes raises my chances to come of, I'll make an effort and try to quit.

I trust the Pubmed site and my psychiatrist highly recommended it.

 

5 hours ago, Shep said:

Please go slowly and let us know how you're doing along the way. 

Sure thing Shep, thank you for your kind advices and tips

[Josef]

 

On 6/2/2021 at 8:04 AM, Altostrata said:

Simply because amisulpride is prescribed as an antidepressant doesn't mean it works.

 

I'm trying to verify your theory that lower doses are activating.

Link that Shep posted earlier

Hey altostrata! in the beginning of the article they say that amisulpride works as a synthetic substitude benzamide compound.

[Josef]

On 6/3/2021 at 2:02 PM, Shep said:

@JosefGoing slow is the most important thing, not the half life, especially if you split the dose if needed for shorter half-lives. 

half life meds and withdrawal

splitting the dose? Based on what evidence? what do you think of the link I've shared?

 

So in general now there's two reasons why I should switch my meds to a similar one (risperidal?)

one is it facilitates more dopamine in low doses, thus much more difficult to handle.

and second reason is that it has shorter half life than others..

 

Just to be clear, I don't want to switch. It's terrifying just to think of it.

 

I think when the time comes i will reduce from 200 to 175 and see how i deal with it.

 

Your guidance would be great Shep, thanks in advance and have a great day everyone!