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MOSweetp40: Antidepressant poster child


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I've been on Paxil 20mg for 20 years. 2 years ago I weaned off it only to experience worsening depression and suicidal thoughts. I had to start to take it again and the doctor added Wellbutrin. I'm also on Trazadone for sleep and anxiety. I struggle 70% of the time with oversleeping,no sex drive,loss of appetite, and actually making myself take walks, go to work etc..my question is is my antidepressants working?


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MOSweetp40 -- Welcome to Surviving Antidepressants (SA)


Although one would think that taking 2 years to taper off 20 mg Paxil would be enough time, it often isn't. It's possible that the "worsening depression and suicidal thoughts" you experienced were delayed withdrawal symptoms not a relapse of original ones. You can read more about that in this topic:

Withdrawal or relapse?


To answer your question, it's possible that you are dealing with adverse effects of the medications. Please look at the "side" effects of the medications on these pages:

Wellbutrin side effects

Trazodone side effects


There are probably interactions between Wellbutrin and trazodone. Please create and read an interactions report, then post here in your introduction topic. Follow the link below to get your report. Just select the text, copy it and paste it in a post here.

Drugs-dot-com Drugs Interactions Checker.



A request: Would you summarize your history in a signature -- drugs, doses, dates, and discontinuations & reinstatements, in the last 12-24 months particularly?

  • Any drugs prior to 24 months ago can just be listed with start and stop years.
  • Please use actual dates or approximate dates (mid-June, Late October) rather than relative time frames (last week, 3 months ago)
  • Spell out months, e.g. "October" or "Oct."; 9/1/2016 can be interpreted as Jan. 9, 2016 or Sept. 1, 2016.
  • Please leave out symptoms and diagnoses.
  • A list is easier to understand than one or multiple paragraphs.
  • You can find instructions in this topic: Please put your withdrawal history in signature
  • If you are using a phone or mobile device, you need to switch to the "full" or desktop version of the site. Instructions are in Post 9 and Post 10
Some other topics relevant to your situation:

Tips for tapering off Wellbutrin XR, SR, XL (bupropion)

Tips for tapering off trazodone (Desyrel)


I hope you'll find the information in the SA forums helpful for your situation. I'm sorry that you are in the position that you need the information, but am glad that you found us.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.
1997-1999 Effexor; 2002-2005 Effexor XR 37.5 mg linear taper, dropping same #beads/week with bad results

Cymbalta 60 mg 2012 - 2015; 2016: 20 mg to 7 mg exact doses and dates in this post; 2017: 6.3 mg to  0.0 mg  Aug. 12; details here

scallywag's Introduction
Online spreadsheet for dose taper calculations and nz11's THE WORKS spreadsheet

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