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chairlifting: Tapering advice for Zoloft


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I've been taking Zoloft for 3 and a half months. I was on 150mg and have begun tapering starting with 100mg 1st week, 50mg 2week, then 0mg as prescribed by my doc.
I'm about to finish week 1 at 100mg and haven't had any noticeable side effects. Does this tapering schedule sound too quick or should I continue where I'm at and go to the 50mg in a few days? I'm very eager to explore alternatives like LSD and psilocybin once I'm off as well or towards the end of the taper.
Edited by manymoretodays
tag, name to title, moved from S and SC
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  • manymoretodays changed the title to chairlifting: Tapering advice for Zoloft
  • Administrator

Welcome, @chairlifting


This site exists because lots of people have found that type of tapering schedule doesn't work for them. We can't predict if you'll be lucky with it.


Withdrawal symptoms can take a while to show up. If I were you, I might stay at 100mg for a couple more weeks to see how it goes. I would definitely make smaller decreases in the next steps. Please see 


Why taper? SERT transporter occupancy studies show importance of gradual change in plasma concentration 


Tips for tapering off sertraline (Zoloft)


Please let us know how you're feeling.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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  • 3 weeks later...

Hello, I am checking back in with you. I've now been on the 100mg dose for 1 month and have felt great. No brain zaps, crying spells or any side effects other than an occasional headache. Would I have felt any withdrawals by now? Would greatly appreciate any suggestions as to what my next move should be. 

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  • Moderator Emeritus

It is recommended to taper by reducing your dose by 10% of the current dose every 4 - 6 weeks.  For example, if your current dose is 5 mg, you taper down to 4.5 mg, and stay there for 4-6 weeks.  If your dose is 1.0 mg, you taper down to 0.9 mg.  This explains it in detail.  


Why Taper by 10% of my Dosage?

Please do not private message me.  Only tag me for urgent questions about tapering and reinstating - thank you.  


***Please note this is not medical advice.  Discuss any decisions about your medical care with a doctor who understands psych meds and how to withdraw from them, if you can find one.


Lexapro   Started Apr 15 2010 - 10 mg;  started taper August 2017, recent taper info: Apr 2 '20  0.18 mg; Jul 16  0.17 mg, Aug 23  0.16 mg, Oct 7  0.15 mg, Nov 8 - 0.14, Jan 16 '21 - 0.13, Feb 7 - 0.12, Feb 22 - 0.11, Mar 26 - 0.10, May 21 - 0.09, June 15 - 0.08 Aug 16 - 0.07, Oct 6 - 0.06, Nov 21 0.05, Dec. 17 0.04, Jan 14 '22 0.03, Feb 19 0.02, Apr 18 0.01, May 15 0.005,  Jul 8, 0.00.  Psych Drug Free as of July 8, 2022!!  Woohoo!!!

other meds: Levothyroxine 75 mg

magnesium in small amounts at 4 AM, before bed

suppl AM: fish oil, flax oil, vit C, vit E, multivitamin, zinc

suppl 8 PM: magnesium 350 mg, extended release vitamin C, melatonin 2 mg


Paxil 2002 - 2010, switched to Lexapro 2010 

Trazodone 50 mg. 2002 - 2019, fast tapered in 2019 

Xanax 0.5 mg as needed 2002 - 2019, up to 3x weekly 

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