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manymoretodays

Hi brianng85,

And just clarifying here too, that PSSD, stands for post- SSRI- sexual disorder.

Meaning that it's onset IS after the drugs are discontinued.

 

And then I've got you started with your Introduction topic here

Started with psycho meds/psychiatric care circa 1988.  In retrospect, and on contemplation, situational overwhelm.

Rounding up to 30 years of medications(30 medication trials, poly-pharmacy maximum was 3 at one time).

5/28/2015-off Adderal salts 2.5mg. (I had been on that since hospital 10/2014)

12/2015---just holding, holding, holding, with trileptal/oxcarb at 75 mg. 1/2 tab at hs.  My last psycho med ever!  Tapered @ 10% every 4 weeks, sometimes 2 weeks to

2016 Dec 16 medication free!!

Longer signature post here, with current supplements.

Herb and alcohol free since 5/15/2016. 

None of my posts are intended as medical advice.  Please discuss any decisions about your medical care with a knowledgeable medical provider. manymoretodays

 

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Hello all,   Although I still have a whole host of symptoms affecting my capacity to be a part of life I want to report on significant progress in respect to pssd. For at least 6-8 months af

In response to a request for more detail about my PSSD:   I had the absolute genital anesthesia at first for quite a while, then that slowly went away, and sexual response gradually returned. This t

To everyone following this thread and to those of you suffering from PSSD and other withdraws related issues such as anhedonia and numbness:   a few few weeks ago I was talking to my brother

Post-SSRI sexual dysfunction may present as persistence of sexual dysfunction caused by the treatment even after its discontinuation, which happens most of the time in the cases of PSSD, or occur only at the time of drug withdrawal.

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brianng85
6 minutes ago, anacleta said:

Post-SSRI sexual dysfunction may present as persistence of sexual dysfunction caused by the treatment even after its discontinuation, which happens most of the time in the cases of PSSD, or occur only at the time of drug withdrawal.

Even you did not have symptoms while on med and after being off the med a few months ?

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32 minutes ago, brianng85 said:

Even you did not have symptoms while on med and after being off the med a few months ?

in my case the symptoms persisted and started at the beginning of treatment.

there are cases where the dysfunction only begins during the period of suspension or shortly thereafter.... "A few months" I don't know...I think there are already testimonials like yours.

pssdforum.org

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Some antidepressants can lead to permanent sexual dysfunction, and Pssd is a syndrome about which little is yet known - Jan 25, 2021 https://it.businessinsider.com/alcuni-antidepressivi-possono-portare-a-disfunzioni-sessuali-permanenti-e-la-pssd-e-una-sindrome-di-cui-si-sa-ancora-poco/

 

Also because of the pandemic, more and more people in Italy suffer from mental disorders such as depression. Many of these patients are treated with SSRI antidepressants: the acronym indicates a series of widespread molecules, at the base of well-known drugs such as, for example, Prozac and Seropram. Drugs that can lead, among the side effects, to disorders related to the sexual sphere. But for some years now, several patients have detected problems of this kind even long after they have stopped taking these drugs: this condition is known as Pssd, Post-SSRI Sexual Dysfunction, an iatrogenic syndrome (i.e. caused by a medicine) with serious repercussions on the quality of life, especially for younger people.

 

"Technically, these drugs are called SSRIs, an acronym that stands for 'selective serotonin reuptake inhibitors,' and are used in the treatment of a range of mental disorders, such as depression but also panic attacks or anxiety syndromes," Dr. Angelo Barbato, psychiatrist and researcher at the Research Unit for Quality of Care in Mental Health, part of the Department of Neuroscience at the Mario Negri Institute for Pharmacological Research, explains to Business Insider Italia. "The use of these drugs has increased a lot in recent years: in Italy in the last 15 years it has doubled, and the latest data collected say that every day 2.5 million compatriots take these drugs."

 

Some of them have developed sexual dysfunction after ending treatment. "The problem is just that. In fact, it is known that while taking these drugs can give problems such as difficulty in erection and reduced libido. 60-70% of those who take these drugs develop these side effects, which are dose-dependent and tend not to be persistent. This was already known. Now it has emerged that there are disorders of this type even in those who have stopped the treatment, with symptoms a bit more complex such as reduced sensitivity of the genital area, reduced ability to feel pleasure or anhedonic orgasms, that is achieved without feeling pleasure," Barbato says.

 

What revealed the existence of the syndrome were "the spontaneous statements of people who took the drugs and then reported these problems," the researcher recalls. "At some point, these reports were brought to the attention of researchers and psychiatrists, who collected a case history and in 2018 submitted a dossier to the drug control agencies (the Food and Drug Administration in the US and the Ema in Europe, ed.) asking that these side effects be included in the leaflet that illustrates the characteristics of the product." As far as Europe is concerned, "the EMEA carried out a preliminary investigation and subsequently gave indications to the countries to include this type of information in the package leaflet. This happened a year ago and Aifa, the Italian drug agency, has acquired the Ema's recommendation: so people who take these drugs should be informed of this risk by the doctors who prescribe them", Barbato says.

 

The syndrome still has several obscure aspects. "It is known that this effect occurs but our information stops there. We don't know in how many cases it occurs, we don't know if it regresses or not, we don't know what other factors may aggravate or reduce the risks of these drugs, and because SSRIs are many we don't know if there are some that give this problem and others that don't," summarizes the researcher. "I am part of a research group that looks at studies of psychotropic drugs, their efficacy, safety, and risks. Then there is a collateral group that deals with studying the mechanisms through which drugs manifest their effects, both beneficial and adverse. We also verify the prescriptive appropriateness, that is, how much the drugs really serve or are used inappropriately. This problem is widespread because the use of these drugs is growing."

 

According to Barbato, "the pandemic has worsened the mental health status of the population and there is a tendency for doctors to prescribe drugs of this type indiscriminately. Ninety-five percent of all prescribed antidepressants fall into the SSRI category and are overused: not all depressions respond to drugs, but psychological treatments are not widespread and many people resort to drugs, with limited benefits and a high risk of adverse events. Eighty percent of people with depression are prescribed such a medication, and of these we estimate that barely 20% have any real benefit. We therefore believe that an information process involving the doctors concerned is necessary: only a few days ago we had a meeting on the subject at the Ministry of Health."

 

The research project of which Dr. Barbato is a part has several goals. "In particular we want to: a) find out if prescribers are aware of this problem and if patients are informed about it: users have the impression that doctors, and especially psychiatrists, are not well aware of the situation and we want to do a survey among psychiatrists to make this verification b) study how many people have reported these effects after taking drugs and how they occur, what is the duration, which drugs are more at risk c) study what mechanisms of the central and peripheral nervous system determine these effects".

 

To bring to light the Pssd were the stories of those who suffer from it, like Laura (fictional name), who for 7 years is living with this problem. "In Italy, we have a chat group with which we keep in touch, as well as a website and other spaces on social networks where we discuss symptoms and any treatments tried; we keep up to date on the progress in recognition and scientific research and we also organize fundraisers to contribute to research." In the PSSD community, the young woman reveals, "there is honestly a lot of despair, these are really difficult conditions to accept and endure because they deprive you of fundamental components that outlined your personality and what you took for granted to be part of your human being. The package inserts recently have been updated with a brief warning and this can help people weigh the pros and cons a little better when prescribing." The problem remains for those already suffering from this syndrome. "We urgently need to get more attention from the medical and scientific world.  If the answer to PSSD could be found, both in the sense of understanding its etiology and in the sense of finding a cure, these drugs, which are so prevalent, could be used by everyone in a safer and more informed way."

 

 

New Evidence on Post-SSRI Sexual Dysfunction (PSSD) - Feb 20, 2021 http://www.laltramedicina.it/notizie/nuove-evidenze-sulla-disfunzione-sessuale-post-ssri-pssd/ 

 

SSRI antidepressants, selective serotonin reuptake inhibitors, and SNRIs, selective serotonin and norepinephrine reuptake inhibitors, comprising numerous active ingredients, are the most widely used classes of psychotropic drugs today; not only are they the drugs of first choice for mood disorders such as major depression, but they are also prescribed for a variety of other disorders, such as anxiety, panic attacks, eating disorders, sleep disorders, in pain therapy, in some forms of headache and even as a treatment against premature ejaculation. Sexual side effects caused by these molecules are really very common: post-marketing studies report a prevalence that exceeds 50% among patients who use them; among the most common symptoms we remember the decrease in libido and the difficulty in reaching orgasm or anorgasmia.

 

In addition to these side effects, which were assumed to be reversible upon discontinuation of treatment, a new evidence has emerged from the reports of patients and has made its way into the medical literature, starting from the first case reports dating back to 2006, which describe cases in which, after having made a "regular" use of these drugs and discontinued them, patients have not had any remission of sexual symptoms and indeed, in some cases those symptoms have appeared or worsened at the time of suspension.

 

Disappearance or reduction of erogenous sensation and sometimes tactile sensation in the genital area, arousal and erection, and anhedonic orgasm, i.e., mechanical and without pleasure, and other orgasmic disturbances, are some of the most common symptoms of post-SSRI sexual dysfunction (PSSD), a persistent syndrome affecting a subgroup of patients who have used serotonergic drugs; those who remain affected emphasize that, prior to such treatment, they had never experienced such symptomatology. A difficult condition to sustain, psychically traumatic and painful that, in males and females, even very young ones, jeopardizes their identity, what were their expectations and desires, of which sexuality and what revolves around it were naturally an integral part, as well as sentimental relationships that come to terms with something unexpected. Those who suffer from PSSD often compare it to a horrifying "permanent chemical castration", which they were never warned about before treatment, and which many physicians to whom they turn for help easily do not recognize the possibility, leaving the patient with "in addition to the damage, the mockery" and for which, worst of all, no cure is known today. The voices of patients and the commitment and courage of some specialists who have taken the problem to heart led the European Medicines Agency (EMA) in 2019 to conduct a careful review of the scientific literature and spontaneous reports received over the years, leading to the decision to require all SSRI and SNRI pharmaceutical companies to update drug indications with a new warning: "Cases have been observed in which symptoms of sexual dysfunction have persisted after discontinuation of treatment."

 

A clue, this, although evasive, which may be useful for those who will have to choose, weighing pros and cons, whether to undergo these treatments, and a meager "recognition" for those who, for years, was already supporting the dramatic and "unfair" condition. Over the course of 2020, one after another, the package inserts of these drugs have been updated. Patients, often faced with inadequate medical answers compared to the evidence they experience firsthand, are finding themselves online, where they compare and keep in touch with each other, form groups and associations nationally and internationally, open websites and organize fundraisers to contribute to the scientific research that is beginning to take hold. https://www.gofundme.com/f/27l8qmes5c.

 

Professor David Healy, psychiatrist, psychopharmacologist, scientist, and author, has been engaged on the research and outreach front on the topic of PSSD since 2012, when he noticed through his website Rxisk.org - which collects reports of adverse drug events - an unexpected number of reports of PSSD and also PGAD: persistent genital arousal disorder, which predominantly affects women and can be triggered precisely by the use and discontinuation of SSRIs and SNRIs. For these conditions, the etiology is currently unknown and there are no known resolving treatments. In 2018, Dr. Healy opened a fundraiser, the Rxisk Prize https://rxisk.org/prize/, designed to reward anyone who finds a cure for PSSD, with the goal of boosting research and drawing media attention to the problem. The prize now exceeds 100 thousand dollars. On the Italian front, important news dates back to 2020, when the Mario Negri Institute for Pharmacological Research began planning the first phases of research, such as a study on psychiatrists' awareness and an epidemiological study, plus further ideas aimed at understanding the etiology of the syndrome. 

 

One of the etiological hypotheses on PSSD that have been advanced over the years, namely that of neurosteroid imbalance in the nervous system following exposure to SSRIs, is being investigated by Professor Roberto Cosimo Melcangi at the University of Milan on an animal model. His research activity has already focused on another iatrogenic syndrome with symptoms quite similar to those of PSSD, namely post-finasteride syndrome. In a 2018 review, Melcangi hypothesized that the two syndromes may have etiological factors in common.

 

PSSD: emblem of something wrong in today's healthcare system

 

In PSSD itself, Dr. David Healy sees an emblem of what is a much broader problem that affects us all. A problem composed of an intertwining of factors that underlie the very functioning of the current drug-health system. To begin with, today "scientific validity" officially refers to RCTs, clinical trials: the results returned by them are considered the "evidence" that allows the approval of drugs. This is despite the fact that clinical trials are designed by the same pharmaceutical companies to meet a primary endpoint that is certainly not to detect the risks and damages caused by the drugs they want to market. To make matters worse, raw data from clinical trials are guarded by pharmaceutical companies and inaccessible to anyone else, even regulators such as the EMA or FDA. Articles in the literature are also written not by the actual authors of the clinical trials but by clever ghostwriters, tasked with highlighting what is wanted to be known. Dr. Healy is confident that the so-called evidence on which today's medicine is based is actually the largest collection of fake news on the planet. Data about drug risks are easily omitted or downplayed.

 

To support this dangerous "implant" there is also a conception of the drug by doctors and the health system that has forgotten a fundamental principle: a drug is primarily a poison, from which it is possible to derive a great benefit. Entering a substance in the body will interact with it causing a myriad of effects and of these, let's say, one hundred effects, one could be the desired one, while the other 99 undesired ones, which could be for us much more relevant than what we are looking for. In prescribing a drug and in taking it, a moral act, a judgment, a human encounter between doctor and patient is required. This is care.

But in recent decades, more and more, the Western world is witnessing a shift from health care to health services: systematic prescriptions of drugs that are supposed to prevent all sorts of health problems, but without considering all the harmful effects of those drugs that accumulate in the body and make us sick. In some industrialized countries life expectancy has begun to decline and to this overprescription of drugs Dr. Healy attributes a central responsibility that is being dangerously overlooked. Those who are harmed by drug treatment, as in the case of PSSD, witness a disconcerting scenario: they become practically invisible.

 

The doctor to whom one turns, not finding document ary "evidence" in the medical literature, disavows the patient's testimony. Moreover, any report to the pharmacovigilance authorities will be considered as an "anecdote". People harmed by drugs are victims of an entire health system that, after having subjected them to risks without any act of "judgment", prefers to abandon and deny them, when these people, in the flesh, are themselves the most concrete and real evidence of the possible consequences of treatments.

 

In his latest book "The Shipwreck of the Singular" David Healy explains how the healthcare system has evolved to reach this critical point that now requires our attention, but also a shared and courageous effort in the name of safeguarding all of us.

Those who wish to follow the conference can do so by clicking on this link: https://m.youtube.com/watch?v=mySezuvPBGk

 

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  • 4 months later...

Hi. I know this section of the forum is the hardest one. Sorry if I just ask here, I am so sick of the forums around on this pssd topic... I come in peace.

My question is,for someone who have read much more stories than I, is it possible to develop this pssd 13 months off? Or it's just the very very bad wave that hit me (now more than a month... appetite sleep anxiety touch sensitivity all disregulated) that brought this sexual disfuncion (anesthesia,zero libido,pleasureless orgasm) too?

On the drug at the <5mg doses i was doing ok and in these previous 13 months I was ok too on this side.

Thanks if someone answers.

06/2012 - 02/2015 CIPRALEX 10 mg (given by GP motivation: I developed left abdomen pain for ca. 2 yr probably due to MD stress) - prior to this NOT any significant episode of anxiety/depression - on medication: emotional-sexual numbness, total inability to cry, +8 kg even with going to the gym, mild fatigue -> abdominal pain gone

02/2015 - 1/04/2015 tapering from 10 mg to 0 mg because I had enough of the numbness following GP advise

05/05/2015 SUDDENLY never-had-before huge anxiety, burning skin sensation, panic, fear, not able to cry again, never-had-before insomnia, totally lost appetite, little loss of vision in one eye, sweating, chest pain, short breath, restlessness, accelerated heartbeat 

30/05/2015 reinstated 8mg (I was suggested 5 mg here, but I had a fight with my GP that he knows better...last time I gave him credibility -__- )

middle 07/2015 general improving

09/2015 quite stable 10/2015 start tapering 7mg  11/2015 6mg  12/2015 5mg 1/2016 4mg  2/2016 4mg  3/2016 3mg ->FAIL back to 4mg AGAIN.... 8/2016 3mg 8/2017 2mg  (had a very short wave in summer '17) 8/2018 2mg stable  8/2019 1mg  1/2020 tried  ~0.6 mg 1/4/2020 0mg FREE!

7/2020 till end 9/2020 MILD WD (mostly anxiety, poor sleep)

11/6/2021 13 MONTHS OFF FULL WD WAVE (anxiety, severe insomnia, total loss of appetite, deep depression, internal restlessness, sexuality gone) trying to resist 😫

SUPPLEMENTS 2021 0.5g melatonin, magnesium, eating a lot of fish + exercise, no alcol, very low caffeine, low carb

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  • 3 weeks later...
GeoJeep

I would like to preface this by stating that I am aware of the NSFW nature of topics such as ED and PSSD, so I will try to word this using as few graphic details as possible. I would also like to note that I have lived with OCD for most of my life and, as is typical among those of us with OCD, I have been a hypochondriac since long before my adverse reaction to meds, and, as such, I am naturally inclined to panic at the appearance of any new symptoms. Having said that, I’ll get to the point.

 

I’ve had a very stressful couple of weeks, and my mental state has been rapidly deteriorating. A couple of nights ago, after experiencing a week of progressively increasing anhedonia, fatigue, and GI distress, I found that I suddenly had a great deal of difficulty achieving an erection, and the quality of any erection that I could achieve was not as good as it was before. It’s only been a few days, but this has yet to resolve.

 

Given that my most debilitating symptoms at the moment are cognitive impairment and anhedonia/emotional anesthesia, which, to my understanding are linked with PSSD, I am terrified that I am beginning to develop it. I don’t have any outstanding genital numbness, or at least any that is profound enough for me to definitively say that I have less sensation now that I did pre-ssri, which I’m hoping is a good sign. However, my libido has been steadily decreasing since this all started, and I have also been increasingly experiencing PE.
 

I suppose it is possible that these symptoms could be the result of the past 7 months of extreme stress and abject terror coupled with the fact that I’ve been terrified of PSSD since the beginning of this nightmare, but I can’t shake the thought that I’m starting to develop it. I imagine PSSD is one of those things where if you have it, you know you have it, but I can’t seem to convince myself that this isn’t PSSD. Anyone out there have any thoughts as to what this is?

12/23/20 - started fluoxetine 20mg/day

1/2/21 - adverse reaction symptoms appeared

1/5/21 - stopped fluoxetine CT

present - some symptoms have remitted, but most have remained

 

Symptoms that have fully remitted: phantosmia, burning/tingling sensations on skin, muscle spasms

 

Symptoms that have partially remitted: numbness, DP/DR, impaired coordination, panic attacks

 

Symptoms that are still present: mental and physical fatigue, cognitive impairment(memory, concentration, problem solving, executive function, etc…), visual snow/retinal after images, headaches, feeling hungover, anhedonia, aphasia, loss of emotions, confusion/disorientation, loss of appetite, exercise intolerance, sensitivity to light/sound/temperature, depression, anxiety, “nervous system overload” feeling, sexual dysfunction(remitted and relapsed)

 

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I also deal with something similar. I'm now 16 months off, for me it started more than 2 months ago.

 

I had a bad idea to read here and there in the pssd forums, please don't do it.

 

Anyway for what i got: either you have it on the drug and it continues or you first have the wd then it slowly moves in pssd in weeks/months. 

However i see both of us has lack of joy,lack of appetite, depression, anxiety and so on. So i assume in this state noone will have a "normal" sexuality.

Maybe if the other things get better this will get better too.

I am scared as you of course but unless you want to try with billions of supplements/meds we just have to wait  :(

 

06/2012 - 02/2015 CIPRALEX 10 mg (given by GP motivation: I developed left abdomen pain for ca. 2 yr probably due to MD stress) - prior to this NOT any significant episode of anxiety/depression - on medication: emotional-sexual numbness, total inability to cry, +8 kg even with going to the gym, mild fatigue -> abdominal pain gone

02/2015 - 1/04/2015 tapering from 10 mg to 0 mg because I had enough of the numbness following GP advise

05/05/2015 SUDDENLY never-had-before huge anxiety, burning skin sensation, panic, fear, not able to cry again, never-had-before insomnia, totally lost appetite, little loss of vision in one eye, sweating, chest pain, short breath, restlessness, accelerated heartbeat 

30/05/2015 reinstated 8mg (I was suggested 5 mg here, but I had a fight with my GP that he knows better...last time I gave him credibility -__- )

middle 07/2015 general improving

09/2015 quite stable 10/2015 start tapering 7mg  11/2015 6mg  12/2015 5mg 1/2016 4mg  2/2016 4mg  3/2016 3mg ->FAIL back to 4mg AGAIN.... 8/2016 3mg 8/2017 2mg  (had a very short wave in summer '17) 8/2018 2mg stable  8/2019 1mg  1/2020 tried  ~0.6 mg 1/4/2020 0mg FREE!

7/2020 till end 9/2020 MILD WD (mostly anxiety, poor sleep)

11/6/2021 13 MONTHS OFF FULL WD WAVE (anxiety, severe insomnia, total loss of appetite, deep depression, internal restlessness, sexuality gone) trying to resist 😫

SUPPLEMENTS 2021 0.5g melatonin, magnesium, eating a lot of fish + exercise, no alcol, very low caffeine, low carb

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GeoJeep
13 hours ago, Marta said:

I also deal with something similar. I'm now 16 months off, for me it started more than 2 months ago.

 

I had a bad idea to read here and there in the pssd forums, please don't do it.

 

Anyway for what i got: either you have it on the drug and it continues or you first have the wd then it slowly moves in pssd in weeks/months. 

However i see both of us has lack of joy,lack of appetite, depression, anxiety and so on. So i assume in this state noone will have a "normal" sexuality.

Maybe if the other things get better this will get better too.

I am scared as you of course but unless you want to try with billions of supplements/meds we just have to wait  :(

 

I actually just found out this morning that I have a severe bacterial infection, so I’m hoping that is the root of the issue. At the very least, I’m sure it’s keeping my brain from healing.

12/23/20 - started fluoxetine 20mg/day

1/2/21 - adverse reaction symptoms appeared

1/5/21 - stopped fluoxetine CT

present - some symptoms have remitted, but most have remained

 

Symptoms that have fully remitted: phantosmia, burning/tingling sensations on skin, muscle spasms

 

Symptoms that have partially remitted: numbness, DP/DR, impaired coordination, panic attacks

 

Symptoms that are still present: mental and physical fatigue, cognitive impairment(memory, concentration, problem solving, executive function, etc…), visual snow/retinal after images, headaches, feeling hungover, anhedonia, aphasia, loss of emotions, confusion/disorientation, loss of appetite, exercise intolerance, sensitivity to light/sound/temperature, depression, anxiety, “nervous system overload” feeling, sexual dysfunction(remitted and relapsed)

 

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  • 1 month later...

Hello @GéoJeep how are you now?  Is your sexual problem and your mental state evolving in the right direction?

Hello everyone, I was on seroplex 10mg in October 2019 for over a year and then on brintellix from March to September for maybe 8 months. I made several attempts to stop abruptly then I resumed the treatment of brintellix recently for a few weeks because it was too difficult to stop.
Symptom when stopped: premature ejaculation, ejaculation with less orgasm. Severe insomnia, transient headaches, sensitivity to noise and light.
Last intake of brintellix 5mg: Saturday, September 11, 2021

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@ParisienMentally, I’m not doing too hot. I finally got in with a urologist last week, and apparently my prostate is swollen to the size of a tomato and is very inflamed, so I’m not currently thinking it’s PSSD. The urologist thinks it’s infected, and I’m waiting on the results of a seminal fluid test to confirm it.

12/23/20 - started fluoxetine 20mg/day

1/2/21 - adverse reaction symptoms appeared

1/5/21 - stopped fluoxetine CT

present - some symptoms have remitted, but most have remained

 

Symptoms that have fully remitted: phantosmia, burning/tingling sensations on skin, muscle spasms

 

Symptoms that have partially remitted: numbness, DP/DR, impaired coordination, panic attacks

 

Symptoms that are still present: mental and physical fatigue, cognitive impairment(memory, concentration, problem solving, executive function, etc…), visual snow/retinal after images, headaches, feeling hungover, anhedonia, aphasia, loss of emotions, confusion/disorientation, loss of appetite, exercise intolerance, sensitivity to light/sound/temperature, depression, anxiety, “nervous system overload” feeling, sexual dysfunction(remitted and relapsed)

 

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@GéoJeep I keep my fingers crossed for you to keep us informed of your condition

Hello everyone, I was on seroplex 10mg in October 2019 for over a year and then on brintellix from March to September for maybe 8 months. I made several attempts to stop abruptly then I resumed the treatment of brintellix recently for a few weeks because it was too difficult to stop.
Symptom when stopped: premature ejaculation, ejaculation with less orgasm. Severe insomnia, transient headaches, sensitivity to noise and light.
Last intake of brintellix 5mg: Saturday, September 11, 2021

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@ParisienHonestly, the sexual symptoms don’t really bother me very much. Most days, they aren’t very bad. It’s everything else that I’m worried about. I would like to have one day where I can think straight, not be constantly dizzy, or have a throbbing headache.

12/23/20 - started fluoxetine 20mg/day

1/2/21 - adverse reaction symptoms appeared

1/5/21 - stopped fluoxetine CT

present - some symptoms have remitted, but most have remained

 

Symptoms that have fully remitted: phantosmia, burning/tingling sensations on skin, muscle spasms

 

Symptoms that have partially remitted: numbness, DP/DR, impaired coordination, panic attacks

 

Symptoms that are still present: mental and physical fatigue, cognitive impairment(memory, concentration, problem solving, executive function, etc…), visual snow/retinal after images, headaches, feeling hungover, anhedonia, aphasia, loss of emotions, confusion/disorientation, loss of appetite, exercise intolerance, sensitivity to light/sound/temperature, depression, anxiety, “nervous system overload” feeling, sexual dysfunction(remitted and relapsed)

 

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EmptyVessle

"Post selective serotonin reuptake inhibitor syndrome (PSSRIS) is a seemingly rare condition where hypoanaesthesia of the genital area, loss of sexual desire and erectile dysfunction occur as soon as after the first dose of medication or more commonly within a course of the medication. The effects are permanent and are highly distressing to patients. I personally warn every patient I put onto SSRIs or SNRIs that PSSRIS is a rare possibility. David Goldmeier Faculty Member Psychiatry / Sexual Dysfunction St Mary's Hospital London UK"

 

Apparently PSSD/PSSRIS is permament according to David Goldmeier. I have noticed any improvements for 2,5 yerars myself. On the other hand there are some people claiming to be recovered from it. 

 

So, what is the truth? Im devastated..

2009.01 - 2009.08 paroxetine 20 mg
2010 - 2012  - sertaline 25mg
2012 -  2013 - moclobemie 600 mg
2014 - 2015 - sertraline 50 mg

2016 - 2018 - sertraline 150 mg

2019 - 2019.03 - sertraline 100 mg and fluwoxamine 50 mg

2020.09.17 - ONE pill trazodone 50 mg

2020.09.17 - today - drugs free 

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Borisboris
On 2/19/2021 at 10:29 AM, anacleta said:

Post-SSRI sexual dysfunction may present as persistence of sexual dysfunction caused by the treatment even after its discontinuation, which happens most of the time in the cases of PSSD, or occur only at the time of drug withdrawal.

 

 

There is something I wonder about that : is there a difference between pssd sufferers who had already sexual dysfunction while on ssri and those who got it only after quitting ? Do they have  the same symptoms, the same lenght of pssd ? 

 

I've had sexual dysfunction since I decreased citalopram.

  • Antidepressants

2008 :Citalopram 60 mg for depression.

2015 : Abrupt decrease of citalopram from 60 to 20 mg. 

2017 : Back to 60 mg citalopram. 

2018 : 40 mg citalopram (abrupt decrease)

2020-2021 : Very slow decrease of citalopram, 12 months duration, from 40 mg to 5 mg. 

July-August 2021 Switch from citalopram to vortioxetine, up to 15 mg, then decrease it to 5 mg in 40 days.

September 2021 : Start to tapper off vortioxetine very slowly, from 5mg.

 

  • Benzodiazepines :

2008 - 2012 clonazepam

2012 - 2021  lorazepam

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Borisboris

And another question : do sexual dysfunction last longer than other wd symptoms, or is it the same ?

  • Antidepressants

2008 :Citalopram 60 mg for depression.

2015 : Abrupt decrease of citalopram from 60 to 20 mg. 

2017 : Back to 60 mg citalopram. 

2018 : 40 mg citalopram (abrupt decrease)

2020-2021 : Very slow decrease of citalopram, 12 months duration, from 40 mg to 5 mg. 

July-August 2021 Switch from citalopram to vortioxetine, up to 15 mg, then decrease it to 5 mg in 40 days.

September 2021 : Start to tapper off vortioxetine very slowly, from 5mg.

 

  • Benzodiazepines :

2008 - 2012 clonazepam

2012 - 2021  lorazepam

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CharlieBrown
Posted (edited)
8 hours ago, Borisboris said:

There is something I wonder about that : is there a difference between pssd sufferers who had already sexual dysfunction while on ssri and those who got it only after quitting ? Do they have  the same symptoms, the same lenght of pssd ? 

 

I've had sexual dysfunction since I decreased citalopram.

 

6 hours ago, Borisboris said:

And another question : do sexual dysfunction last longer than other wd symptoms, or is it the same ?

 

I believe everyone reacts differently. People's experiences are of different lengths and have different symptoms.

Some people have bad reactions to small amounts. I don't think there is a definitive answer to either of those questions. Maybe others could share their experience.

I had dysfunction while on a "regular dose", and also while completely medication free.

For me the dysfunction lasted longer than the mental symptoms. But I know there are many people, who struggle with memory, depression, lethargy, anxiety, "zaps" and a lot of other physical/mental issues for a long time.

Edited by CharlieBrown
typo

Prescribed Various SSRI's, Benzodiazepines and Risperidone in 2009 for Anxiety.

Tapered off SSRI's within one year. Abrupt ending with Risperidone.

Recovered from medication side effects!

My success story: 

 

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CharlieBrown

BorisBoris here is a great explanation from the Admin.

On 11/1/2019 at 2:43 PM, Altostrata said:

@Haleybeans I added your post to our existing very long discussion about PSSD.

 

Sexual dysfunction can start when you're taking psychiatric drugs or when you stop taking them. It is a sign of general nervous system and body upset from the effect of psychiatric drugs, and tends to fade over time.

 

We don't have many reports of PSSD starting after some months off drugs, but it's possible.

 

Prescribed Various SSRI's, Benzodiazepines and Risperidone in 2009 for Anxiety.

Tapered off SSRI's within one year. Abrupt ending with Risperidone.

Recovered from medication side effects!

My success story: 

 

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Borisboris

Ok Charliebrown, thanks for your response.

 

I'm currently tappering off my antidepressant, and it is very stressful not to know when my sexual function will come back and even if it will come back.

 

  • Antidepressants

2008 :Citalopram 60 mg for depression.

2015 : Abrupt decrease of citalopram from 60 to 20 mg. 

2017 : Back to 60 mg citalopram. 

2018 : 40 mg citalopram (abrupt decrease)

2020-2021 : Very slow decrease of citalopram, 12 months duration, from 40 mg to 5 mg. 

July-August 2021 Switch from citalopram to vortioxetine, up to 15 mg, then decrease it to 5 mg in 40 days.

September 2021 : Start to tapper off vortioxetine very slowly, from 5mg.

 

  • Benzodiazepines :

2008 - 2012 clonazepam

2012 - 2021  lorazepam

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Borisboris

From what I've read, most people who have pssd have genital numbness. In my case it was the contrary, I had genital hypersensitivity after a big decrease of citalopram (Going back to a higher dose cured it). Maybe it means that what I have is more like a withdrawal than PSSD. That could make sense because citalopram gave me an erectile improvement and a slight numbness, so the withdrawal got me erectile dysfunction and hypersensitivity. So the question is : are wd symptoms faster to improve than pssd ? I guess no-one has the response but... well, I know I think too much.

  • Antidepressants

2008 :Citalopram 60 mg for depression.

2015 : Abrupt decrease of citalopram from 60 to 20 mg. 

2017 : Back to 60 mg citalopram. 

2018 : 40 mg citalopram (abrupt decrease)

2020-2021 : Very slow decrease of citalopram, 12 months duration, from 40 mg to 5 mg. 

July-August 2021 Switch from citalopram to vortioxetine, up to 15 mg, then decrease it to 5 mg in 40 days.

September 2021 : Start to tapper off vortioxetine very slowly, from 5mg.

 

  • Benzodiazepines :

2008 - 2012 clonazepam

2012 - 2021  lorazepam

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Altostrata

Genital hypersensitivity may be called Persistent genital arousal disorder (PGAD). It is a drug-induced symptom parallel to PSSD.

 

Please use search in the Introductions forum to see cases of PGAD. Like PSSD, we have seen it gradually go away over months.

 

PGAD and PSSD tend to gradually lessen, with occasional recurrences at lesser intensity as time goes on. Withdrawal symptoms tend to appear in waves, wax and wane, change and recur, also at lower intensity as time goes on.

 

Nobody can say if PGAD or PSSD lasts longer than withdrawal symptoms, they can be among withdrawal symptoms. Generally, if you feel better from other withdrawal symptoms, PGAD and PSSD also improve.

 

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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Altostrata

This site is not specifically about PSSD or PGAD. Some of our people, not a majority, have had these symptoms. We do see recovery.

 

If you want to confer with a larger number of people experiencing PSSD, please join pssdforum.org

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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Borisboris
29 minutes ago, Altostrata said:

Genital hypersensitivity may be called Persistent genital arousal disorder (PGAD). It is a drug-induced symptom parallel to PSSD.

 

 

 

What i had was definitely not PGAD or something similar. It was only imconfort and even pain caused by, for example, rubbing clothes. I couldn't have a sexual intercourse without condom because the pain would have been unbearable.

  • Antidepressants

2008 :Citalopram 60 mg for depression.

2015 : Abrupt decrease of citalopram from 60 to 20 mg. 

2017 : Back to 60 mg citalopram. 

2018 : 40 mg citalopram (abrupt decrease)

2020-2021 : Very slow decrease of citalopram, 12 months duration, from 40 mg to 5 mg. 

July-August 2021 Switch from citalopram to vortioxetine, up to 15 mg, then decrease it to 5 mg in 40 days.

September 2021 : Start to tapper off vortioxetine very slowly, from 5mg.

 

  • Benzodiazepines :

2008 - 2012 clonazepam

2012 - 2021  lorazepam

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On 10/2/2021 at 4:12 AM, EmptyVessle said:

"Post selective serotonin reuptake inhibitor syndrome (PSSRIS) is a seemingly rare condition where hypoanaesthesia of the genital area, loss of sexual desire and erectile dysfunction occur as soon as after the first dose of medication or more commonly within a course of the medication. The effects are permanent and are highly distressing to patients. I personally warn every patient I put onto SSRIs or SNRIs that PSSRIS is a rare possibility. David Goldmeier Faculty Member Psychiatry / Sexual Dysfunction St Mary's Hospital London UK"

 

Apparently PSSD/PSSRIS is permament according to David Goldmeier. I have noticed any improvements for 2,5 yerars myself. On the other hand there are some people claiming to be recovered from it. 

 

So, what is the truth? Im devastated..

 

And yet we have seen PSSD resolve. You may choose what you want to believe about your own condition.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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I want to know the truth, it is very unlike that it can resolve.

2009.01 - 2009.08 paroxetine 20 mg
2010 - 2012  - sertaline 25mg
2012 -  2013 - moclobemie 600 mg
2014 - 2015 - sertraline 50 mg

2016 - 2018 - sertraline 150 mg

2019 - 2019.03 - sertraline 100 mg and fluwoxamine 50 mg

2020.09.17 - ONE pill trazodone 50 mg

2020.09.17 - today - drugs free 

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What you want to know is your personal future. Nobody can predict that. Sorry.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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@Altostrata I dont want future without emotions, sexuallity, joy, cognition. I need to be sure if its worth to wait and suffer longer. You have no idea how painfull it is every single day.

2009.01 - 2009.08 paroxetine 20 mg
2010 - 2012  - sertaline 25mg
2012 -  2013 - moclobemie 600 mg
2014 - 2015 - sertraline 50 mg

2016 - 2018 - sertraline 150 mg

2019 - 2019.03 - sertraline 100 mg and fluwoxamine 50 mg

2020.09.17 - ONE pill trazodone 50 mg

2020.09.17 - today - drugs free 

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It's odd, none of the 16,000 members of this site seem to like suffering long-term symptoms related to psychiatric drugs. I actually do know what this is like, having been told 16,000 times and experiencing it for many years myself.

 

Please look around you and see that a lot of people are going through similar distress, it's not just you, and nobody knows what their individual future is. We see a trend towards recovery, though it can be very slow.

 

You may need to learn how to cope with this uncertainty and direct your thoughts and efforts towards healing rather than making yourself worse with worry and anxiety over a doom that may never come to pass.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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2 hours ago, EmptyVessle said:

@Altostrata I dont want future without emotions, sexuallity, joy, cognition. I need to be sure if its worth to wait and suffer longer. You have no idea how painfull it is every single day.


It comes back. Just takes time. Hang in there. Build some good habits (i.e., daily guided meditation, walks with nature). Find good moments. 

 

May also be helpful to find a skilled MD and therapist if you’re struggling with these thoughts. 

Previously - Escitalopram ("Lexapro"): 03 - 05/2018 - 10mg // 05/2018 - 12/2019 - monthly hyperbolic dose reduction to 0.

 

I am not a medical doctor.  Always consult a qualified medical professional before taking any substance.

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@Altostrata

 

How come some people claims to be "recovered" within few months or few years and on the other hand I have found over 200+ cases that suffer from protracted withdrawal (mostly pssd) for over 15+ years without improvement.

 

I mean if damage is permament with this drugs, it should affect everyone. 

 

If not - well, everyone should recover sooner or later.

 

My opinion is that there is no such thing as recovery, only improvement to some point that people can somehow 'accept' what has happened and claimed to be 'recovered'.

 

It just does not make any sens, this dissonace. 

 

I quit drugs 2,5 years ago and there have not been any changes in symptomps since then. So why should I think that all of the sudden a miracle will happen and my body/brain will start to healing since it has not for 2,5 years already?

 

Can someone please help me understand?

2009.01 - 2009.08 paroxetine 20 mg
2010 - 2012  - sertaline 25mg
2012 -  2013 - moclobemie 600 mg
2014 - 2015 - sertraline 50 mg

2016 - 2018 - sertraline 150 mg

2019 - 2019.03 - sertraline 100 mg and fluwoxamine 50 mg

2020.09.17 - ONE pill trazodone 50 mg

2020.09.17 - today - drugs free 

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You can believe what you want about your future. Please do not tag me again with this unanswerable question.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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@Spruce30 Hi, i read your posts, how are you now? 

My symptoms are also like yours, symptoms better in the morning, and at night, it's complete impotence. Symptoms seem to be best around midday. 

 

Windows are far spaced from each other, now they seem to be less intense, and a bit longer. I will check again here and hopefully hear a positive reply from you. 

@1Day your posts also intereste me. 

 

I am 2 years pssd, it took me a long while to realize what it is. It seems worsening was gradual. I noticed impotence after 5 months when i failed to have an erection. 

Nofap for almost a year didn't help with anything but made me feel a bit more normal during the short Windows i have. Sometimes i can have erection but it doesn't last long before i am not able to feel aroused anymore. It's like my arousal doesn't last long. 

 

Anhedonia and pssd made me feel dead, less of a man, I haven't made any progress in life during past 2 years because of this, being bed ridden and lacking any motivation to live. Suicidal thoughts are more intense and urges to do it are creeping in stronger and stronger and it feels like the right thing to do, especially for the last 2 weeks. Feeling more hopeless than ever. It's hard to cope anymore, being jobless, feeling useless and have most of the day to not do anything but think of pssd. It feels i have ptsd because of this. I can't stop thinking of the day i took the first pill. I have only took ssri for few weeks. 

Venlafaxine 25mg twice a day ( taken for 2 weeks in December 2019)

Propranolol (20mg-40mg-60mg) doses most of January 2020.

Prazepam 10mg occasionally from December 2019 to February 2020. 

Venlafaxine 25mg twice again 1 week in February 2020.

At the moment i am clean. 

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15 hours ago, PiedoDerPSSD said:

Anhedonia and pssd made me feel dead, less of a man, I haven't made any progress in life during past 2 years because of this, being bed ridden and lacking any motivation to live. Suicidal thoughts are more intense and urges to do it are creeping in stronger and stronger and it feels like the right thing to do, especially for the last 2 weeks. Feeling more hopeless than ever. It's hard to cope anymore, being jobless, feeling useless and have most of the day to not do anything but think of pssd. It feels i have ptsd because of this. I can't stop thinking of the day i took the first pill. I have only took ssri for few weeks. 


Have you considered that sexual function might return after you tend to other aspects of your life?  If you're jobless and hopeless, that's not really conducive to feeling alive and energized.

 

At the risk of coming across as dismissive, I'd suggest focusing on your emotional state first, then your job situation second, then any remaining "performance" issues after that.

 

Regular cardio and guided meditation can work wonders on the first point. It's very uncomfortable to do, but you would essentially be rewiring your brain out of this pattern that's not serving you.

 

If you are having suicidal thoughts, please see an MD or therapist.

Previously - Escitalopram ("Lexapro"): 03 - 05/2018 - 10mg // 05/2018 - 12/2019 - monthly hyperbolic dose reduction to 0.

 

I am not a medical doctor.  Always consult a qualified medical professional before taking any substance.

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Excellent suggestions, @ccfb (except I would not see an MD for suicidal thoughts, all you'l get is a drug prescription).

 

Focusing on the condition of your genitals will not help you recover sexual functioning. Self-consciousness has never been good for this.

 

Fixating on your victimhood is also disempowering. All of our members have been cheated by the medical profession in one way or the other. It's a universal outrage, not just yours. You need to figure out how to help yourself (and others) recover, not dwell on your personal shortcomings.

This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner.

"It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein

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Does anybody else's symptoms get worse after orgasm? 

In the past orgasming 4 or 5 times a day was normal and would be still horny and responsive to sexual stimulation. But now, after an orgasm, i crash badly and wouldn't be able to get an ok erection for few days. 

 

Also erections with a partner seem to be better than when i am alone or with porn. 

 

If i abstain for a long period, then i would be able to orgasm several times before i crash again. 

 

Viagra doesn't work immediately, but after a day or two, it would trigger a window of normal function for 3 up to 4 or 5 days if i don't orgasm much. 

 

What does this tell you? Do you think nitric oxide supplements would help in my case? Why would viagra act in this strange pattern? 

 

Do you think i can live normal with viagra 2 to 3 times a week? Or would it become ineffective after few years of over use?? 

 

 

 

Just expressing my emotions (mod can delete this part if it's against rules): 

Sorry for being too emotional, i become like this during my Lowest moods of pssd, i lose my rational thinking, but i really needed to write it and let it all out, as i tens to keep all of it to myself in real life, i am better today and not thinking of suicide. I am against it, i still want to live, achieve something in life and have a family. 

I have met a woman, she's understanding, but i am not sure if she would tolerate this much longer, i became too needy with her as well and i am afraid this would turn her off. I had a much higher confidence when i had strong hope this curse would go away in a year or so, i did nofap for a year, i trained hard and lived as healthy as i coud, things seemed going worse, so i broke down mentally and gave up.  Also i would have not hesitated if i could fix many parts of my life, but i live in a third world country and i don't have much options, choices or opportunities to turn my life around, i have a mechanical engineering university degree, yet i am jobless unfortunately, i have worked all kind of labor jobs but this hasn't taken me anywhere forward in life. So now i am living with my parents. 

 

I need to snap out of this emotional trauma and continue living with what i have. Sometimes i think, others had it worse, nothing is granted in life, i watched a video some weeks ago of a boxer who got hit on the head and now he's mentally and physically handicapped and his life was ruined forever. It seems pssd is the better choice if i had to choose between these two. A friend was hit by a bottle of wine on the back of his head in a bar fight, now he's been on a wheelchair for 3 years and his iq has dropped in half. Pssd is hard as a condition, and nobody should have had this, but i am just saying to make me feel better and anybody else reading this. 

 

Sorry for long post and thanks for reading.

Venlafaxine 25mg twice a day ( taken for 2 weeks in December 2019)

Propranolol (20mg-40mg-60mg) doses most of January 2020.

Prazepam 10mg occasionally from December 2019 to February 2020. 

Venlafaxine 25mg twice again 1 week in February 2020.

At the moment i am clean. 

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Does anyone has experience with berberine and inositol? Do you think they could help my baseline as some people claim? 

 

I have been eating zinc supplements, i have severe zinc deficiency, visible from white spots on fingernails. Zinc makes my pssd worse, i lose morning wood when taking much zinc. But i have to continue with the treatment until at least not be zinc deficient anymore. Who else is taking zinc? Does it effect your ED?

Venlafaxine 25mg twice a day ( taken for 2 weeks in December 2019)

Propranolol (20mg-40mg-60mg) doses most of January 2020.

Prazepam 10mg occasionally from December 2019 to February 2020. 

Venlafaxine 25mg twice again 1 week in February 2020.

At the moment i am clean. 

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