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PSSD Post-SSRI sexual dysfunction

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escitalopramsucks

I did. You have a private message there... I´m waiting for response

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btdt

I am also waiting on a response here not at the other site...when you have time. 

peace

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Gh0st

The following form I wrote hopes to address Contributing/Treatment Factors to PSSD (Age, Gender, Time on Drug, Time off Drug, What Has Worked For You). It will be incredibly valuable information to have. I'll analyze it and turn it into something resembling an academic paper.

>> http://goo.gl/forms/DfGT8Ihpyn1zEx5x2 <<

The sad fact is that we can't really get a fair sample for this. If we could get everyone with PSSD to answer, we'd have a better idea. But I'm assuming some ages and patient types are less likely to have trickled onto this forum. Regardless, I'm going to give it a go. I'll be collecting data and eventually be writing it into a paper. I URGE EVERYONE TO SPEND 5 MINUTES FILLING THIS OUT. IT WILL BE INCREDIBLY VALUABLE! PLEASE SHARE ON ANY PSSD PLATFORM THAT YOU KNOW OF! The data is more helpful if more people do this.

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Area1255

I am also waiting on a response here not at the other site...when you have time. 

peace

Sorry friend, ventured away from here a little bit. Had some distractions going on.

 

New study: "Persistent sexual dysfunction after early exposure to SSRIs: Systematic review of animal studies"

 

https://www.researchgate.net/publication/301830365_Persistent_sexual_dysfunction_after_early_exposure_to_SSRIs_Systematic_review_of_animal_studies

Yeah, doesn't give much information there though. You have to upgrade or log in to a clinician's account. The rest of it isn't really all that new, most of it I've put in my article and has to do with gonadotropin downregulation and a diminished oxytocin response.

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escitalopramsucks

31/05/2016

 

I visited a top endocrinologist... she diagnosed hypothiroidism. I'm currently taking levotyroxine. Vitamins b6 and iron and my mood is better. I'm not so so depressed and anxious.

She is gonna check again my hormones and help with pssd.

I recommend you to find a good endoc.

Thanks

 

 

24/06/2016

 

The endocrinologist, according to my last blood data has put me in an hormonal treatment as she has found "The analysis shows that it is not yet compensated thyroid deficiency . To have a libido you need about 1 TSH. There are other gaps , small , but added : magnesium deficiency , ferritin and hormone DHEA. Moreover, high estrogen  is shown.

 

This is the medication:

-DHEA 25 mg

-LEVOTIROXINA 25

-PROGESTERONE

 

Apart from:

 

-Iron, B6 vitamin, and magnesium

 

I´m a bit concern about having hormons but this lady is known to have the feet on the fround and she has helped hundreds of people.

 

Since I started the treatment with levotiroxine, B6 and iron, my mensatruation and ovulation are correct again. (Beloved escitalopram shorted my mensatruation lenght of 30 days to 21 and discontinued my ovulations every month, so I hope this will continua improving.

One of the things I have noticed better is the sensations and orgasms that are more intense specially near the mensatruation days and my depression is still here but not as horible as on Christmas time when I was 24/7 having suicidal thoughts. Libido and interest in men are still 0.

Some other big achievements are related to sleep: I sleep better, more hours and my dreams are starting to be more complex and frequent.

 

Have some femine PSSD sufferer try hormonal treatment to exchange experiences?

 

 

Thanks!!

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Area1255

31/05/2016

 

I visited a top endocrinologist... she diagnosed hypothiroidism. I'm currently taking levotyroxine. Vitamins b6 and iron and my mood is better. I'm not so so depressed and anxious.

 

She is gonna check again my hormones and help with pssd.

 

I recommend you to find a good endoc.

 

Thanks

 

 

24/06/2016

 

The endocrinologist, according to my last blood data has put me in an hormonal treatment as she has found "The analysis shows that it is not yet compensated thyroid deficiency . To have a libido you need about 1 TSH. There are other gaps , small , but added : magnesium deficiency , ferritin and hormone DHEA. Moreover, high estrogen  is shown.

 

This is the medication:

-DHEA 25 mg

-LEVOTIROXINA 25

-PROGESTERONE

 

Apart from:

 

-Iron, B6 vitamin, and magnesium

 

I´m a bit concern about having hormons but this lady is known to have the feet on the fround and she has helped hundreds of people.

 

Since I started the treatment with levotiroxine, B6 and iron, my mensatruation and ovulation are correct again. (Beloved escitalopram shorted my mensatruation lenght of 30 days to 21 and discontinued my ovulations every month, so I hope this will continua improving.

One of the things I have noticed better is the sensations and orgasms that are more intense specially near the mensatruation days and my depression is still here but not as horible as on Christmas time when I was 24/7 having suicidal thoughts. Libido and interest in men are still 0.

Some other big achievements are related to sleep: I sleep better, more hours and my dreams are starting to be more complex and frequent.

 

Have some femine PSSD sufferer try hormonal treatment to exchange experiences?

 

 

Thanks!!

Well as a Woman the high estrogen issue is definitely shedding light there on the symptoms you are experiencing. I would definitely listen to your Docs suggestions there and take care of the magnesium deficiency - also consider adding in Zinc at about 15-20 mg, at night or morning, depending on what feels better for you.

 

What's your diet like?

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Area1255
Here's something interesting.
 
Brain Res. 2000 Jul 28;872(1-2):64-70.

Activation of hypothalamic insulin by serotonin is the primary event of the insulin-serotonin interaction involved in the control of feeding.

Abstract

In previous experiments, we reported a close parallelism in the responses of both serotonin (5-HT) and insulin in the hypothalamic PVN-VMH region of freely-moving rats during feeding. Thus, hypothalamic 5-HT and insulin may participate, independently or in interaction, in the control of carbohydrate and fat ingestion. The precedence of the activation of one or the other substance remained to be investigated. In adult male Wistar rats, (a) dexfenfluramine was administered to the PVN-VMH region by reverse microdialysis (80 microM for 10 min) while local insulin was assessed; ( B) insulin was locally infused (400 mU for 10 min) through the tip of the dialysis probe while 5-HT was measured. Dexfenfluramine immediately increased 5-HT release, and also extracellular insulin levels (+102%). This activation of insulin by serotonin is actually a central effect since neither insulinemia nor glycemia were affected. Conversely, insulin enhanced 5-HT release (+81%), but only 45 min after the beginning of its infusion. Noradrenaline, dopamine and metabolites were slightly or not at all modified by insulin. These data demonstrate that an interaction does exist between insulin and 5-HT in the VMH-PVN area. Because of the delay of 5-HT response to insulin, an activation of the serotonergic system would be the causal event acting immediately on insulin, and not the contrary. Whatever the exact mechanism of this interaction, it seems to be a link in a larger cascade of events involving numerous neurotransmitters and peptides leading to the regulation of feeding.

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fema4psychiatrists

Take Action Now Fast  - everyone do this please

 

Print this

 

http://www.mind.org.uk/information-support/drugs-and-treatments/antidepressants/side-effects-of-antidepressants/#se

 

Sometimes these side effects persist after you've come off the drug, and might continue indefinitely. If you experience this you might want to report it on a Yellow Card.”

 

And make your doctor fill out a yellow card reporting form on PSSD like the mind website suggests.

 

My psyche claimed he’s not bothered because the reports of indefinite sexual damage on yellow report system are rare compared to reported sexual dysfunction whilst on the drugs.

 

Lets try and change that

PS: MIND a trusted UK source by all mental health professionals

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Theon

I ended up getting depressed and anxious because I was very obseesed with pssd.. you feel now asexual because of the pssd? so be it, but better asexual than worrying too much about your pssd and getting anxious or depressed, like it has happened to me.

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scallywag

Theon, I get what you're saying and that from your perspective, feeling asexual would be welcome. 

 

It's doubtful that someone who has enjoyed his/her sexuality and sexual activity likes feeling asexual or would consider it better than feeling any other way.  Comparisons are best left to discussing our own symptoms in our own introduction threads.

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Altostrata

No doubt, since aldosterone plays a role in everything.

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Area1255

Just wondering if any men have heard of this treatment? Shockwave therapy. I don't know if it's safe or not.

 

http://www.menshealth.com/health/new-viagra

Mixed results, some say it's worse than ECT/EIT. Some simply get no benefit at all.

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Junglechicken

Anyone got any tips as to how to get "in the mood" whilst experiencing physical symptoms.

 

If it isn't my TOTM, its asthma, if it isn't that then it was the GERD.....and so on. My face and lips are currently red from eczema. Very difficult to feel remotely sexy with back to back symptoms.

 

Although my hubby is an absolute gem, because of me, we haven't gotten jiggy with it for 8 months. This is tough on any man. I wouldn't blame him at all for getting it from elsewhere, but wish I could restore this part of me which is frankly inert.

 

Really need help in this department.

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Junglechicken

Thank you Area1255 - will check it out.

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JanCarol

I understand that the PSSD has definite, chemical, physical factors.  Most of those will heal with time.

 

While you are waiting to heal, I suggest you start looking into strategies that balance your sex drive with that of your partner.

 

Emily Nagoski, PhD runs a blog called "The Dirty Normal" and a book called "Come As You Are" which focuses on the fact that nearly all partners have unequal drives.  Additionally, she talks about negotiating responsive desire as opposed to spontaneous desire.

 

It is a cultural norm that we all should have spontaneous desire, like in the movies, where you just cannot resist the urge anymore and the two of you go at it on the kitchen table, the park, etc.

 

But it is important to learn your responsive desire - how to tickle out those things which feel good, which lead to you wanting to do more things which feel good, which may lead to sexual desire (and may not - it's a learning process, just like going to "Sex U."

 

Start here, and think about your sex in a new way:

http://www.thedirtynormal.com/about/best-of-the-dirty-normal/

 

Please, chemicals, supplements, substances, devices, they are not going to be strong enough.  Especially since 90% of sexy is in the brain.

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Junglechicken

Thank you (other) JC, this is really helpful!

 

Have actually been feeling really down because of this for some time now.

 

My hubby is an absolute rock/gem, whom I don't know what I would do without.

 

It sucks that I struggle for lack of libido, because as I said, it just evaporated due to back to back physical symptoms.

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Area1255

Thank you (other) JC, this is really helpful!

 

Have actually been feeling really down because of this for some time now.

 

My hubby is an absolute rock/gem, whom I don't know what I would do without.

 

It sucks that I struggle for lack of libido, because as I said, it just evaporated due to back to back physical symptoms.

Good to hear JC! Having a committed/supportive partner is always the best magic.

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Area1255

Saffron may help.

Psychopharmacology (Berl). 2012 Oct;223(4):381-8. Epub 2012 May 3.
Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial.
Abstract
RATIONALE:

Saffron (Crocus sativus L.) has shown aphrodisiac effects in some animal and human studies.

OBJECTIVES:

To assess the efficacy and tolerability of saffron in fluoxetine-related sexual dysfunction.

METHODS:

This was a 4-week randomized double-blind placebo-controlled study. Thirty-six married male patients with major depressive disorder whose depressive symptoms had been stabilized on fluoxetine and had subjective complaints of sexual impairment entered the study. The patients were randomly assigned to saffron (15 mg twice per day) or placebo for 4 weeks. International Index of Erectile Function scale was used to assess sexual function at baseline and weeks 2 and 4.

RESULTS:

Thirty patients finished the study. Baseline characteristics as well as baseline and final depressive symptoms scores were similar between the two groups. Effect of time × treatment interaction on the total score was significant [Greenhouse-Geisser-corrected, F (1.444, 40.434) = 6.154, P = 0.009]. By week 4, saffron resulted in significantly greater improvement in erectile function (P < 0.001) and intercourse satisfaction domains (P = 0.001), and total scores (P < 0.001) than the placebo group. Effect of saffron did not differ significantly from that of placebo in orgasmic function (P = 0.095), overall satisfaction (P = 0.334), and sexual desire (P = 0.517) domains scores. Nine patients (60%) in the saffron group and one patient (7%) in the placebo group achieved normal erectile function (score > 25 on erectile function domain) at the end of the study (P value of Fisher's exact test = 0.005). Frequency of side effects were similar between the two groups.

CONCLUSIONS:

Saffron is a tolerable and efficacious treatment for fluoxetine-related erectile dysfunction.

PMID:   22552758   DOI:   10.1007/s00213-012-2729-6

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Futurerecovery

I have sent Prof. Melcangi a few questions. He told me that "they are not presently working on this matter". He says that the questionnaire was probably translated by a patient (he only made the Italian questionnaire). He also says: "Thus, only to explain you that this is a general questionnaire only to have (in case we may work on it) already some information."

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Area1255

PSSD is absolutely a sophisticated disorder, but it seems to be also the result of decreased bodily sensitivity to sex hormones

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Altostrata

PSSD is absolutely a sophisticated disorder, but it seems to be also the result of decreased bodily sensitivity to sex hormones

 

Area, this may be your opinion or your guess. It hardly merits an ex cathedra pronouncement.

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Chuck83

For me PSSD It is a set of various factors neurological and endocrinological. Surely there is a desensitization of 5HT1A receptor. There could be a inhibition of pituitary /gonads.

Do not forget that SSRIs inhibit the reuptake of serotonin, It decreases the availability of dopamine in the brain, and a certain amount of dopamine is essential for a good sexual function, the pituitary inhibition, with the lowering of dopamine, also generally lead to a raising of prolactin which is another killer libido.

Unfortunately, the current medical science has decided not to take an interest in this important issue, then  can only make a speculations.

 

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Area1255

For me PSSD It is a set of various factors neurological and endocrinological. Surely there is a desensitization of 5HT1A receptor. There could be a inhibition of pituitary /gonads.

Do not forget that SSRIs inhibit the reuptake of serotonin, It decreases the availability of dopamine in the brain, and a certain amount of dopamine is essential for a good sexual function, the pituitary inhibition, with the lowering of dopamine, also generally lead to a raising of prolactin which is another killer libido.

Unfortunately, the current medical science has decided not to take an interest in this important issue, then  can only make a speculations.

Yup, desensitization certainly plays a role. However, what we know is that there is a negative feedback loop on gonadotropins, and that gonadotropins themselves attempt to inhibit themselves through CRH and thus, cortisol being a HPTA inhibitor. The study below is useful for determining what contributes to these SSRI-induced hypogonadism cases.

 

Endocrinology. 1992 Apr;130(4):1780-8.

Regulation of corticotropin-releasing factor secretion from Leydig cells by serotonin.
Abstract

CRF is produced in the Leydig cells and acts as a negative autocrine regulator of Leydig cell function. To clarify the hormonal control of CRF secretion by Leydig cells, we evaluated the participation of serotonin (5HT) and serotonin agonists in the release of CRF from Leydig cells and their effects on hCG-induced cAMP generation and steroidogenesis. Serotonin stimulated CRF secretion up to 4-fold above basal levels and inhibited basal and hCG-stimulated cAMP generation and testosterone production (ID50, 1 nM). The inhibitory action of 5HT was prevented by a CRF antibody and the alpha-helical CRF-(9-41) antagonist. The selective 5HT2 receptor agonist (+-)1-[2,5-dimethoxy-4-iodophyryl]2-amino propane hydrochloride (DOI) also stimulated CRF secretion and inhibited hCG-stimulated cAMP generation and testosterone production to control levels (ID50, 7 microM). Serotonergic 5HT1A, 5HT1B/1C, 5HT1D, and 5HT3/5HT2 agonists were less effective inhibitors of hCG-stimulated cAMP and testosterone production, while agonists for the 5HT3 receptor had no effect. [125I]DOI binding studies in Leydig cells demonstrated two sets of receptors with Kd values in the nanomolar and micromolar range, with low and high capacities, respectively. The low affinity site differed from that of brain receptors (Kd, 4.2 nM) and displayed higher binding capacity (50-fold). The selective 5HT2 receptor antagonist ketanserin prevented CRF stimulation and blocked the inhibitory actions of 5HT and DOI, while the alpha 1-adrenergic antagonist prazosin had no effect. Also, treatment of cells with ketanserin increased sensitivity to hCG and raised maximal cAMP and testosterone production. 5HT was a more effective stimulus than hCG in stimulating CRF secretion, and gonadotropin-induced CRF release was inhibited by ketanserin. Inhibitory effects of exogenous CRF were demonstrable after blockade of 5HT action by ketanserin. The inhibitory actions of 5HT were unaffected by pertussis and cholera toxins and were reversed by the addition of 8-bromo-cAMP. These results demonstrate that 5HT acts on 5HT2 receptors in Leydig cells that are distinct from those in the brain to stimulate CRF secretion through a pertussis toxin-insensitive G-protein. This action of 5HT is predominantly mediated by the low affinity 5HT2-binding site and requires full occupancy for maximal CRF stimulation, indicating the absence of spare receptors. 5HT-stimulated CRF inhibits basal and hCG-induced cAMP generation and steroidogenesis. Furthermore, 5HT mediates the stimulatory action of LH/hCG on CRF secretion from Leydig cells and, thus, participates in a negative autoregulatory loop to limit the testosterone response to the gonadotropic stimulus.

PMID:   1312425   DOI:   10.1210/endo.130.4.1312425
[PubMed - indexed for MEDLINE]

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Altostrata

Please note that anything Area posts is his theory or guess and is not endorsed by this Web site.

 

Area, you may offer information you think is relevant but please stop presenting it as an expert opinion. No one, including you, knows exactly what causes PSSD.

 

Please consider this a verbal warning. The next step will be a system warning.

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Chuck83

Last year my endo put on me for one month on dostinex for lowering prolactine i had little high, and pregnyl(HCG inejection) to try to fix PSSD, and raise my testo, I have some benefits but I have not completely solved, however, remember that at that time I was very strong in the gym( I really love training with heavy weights), I had a lot of energy, High Libido, the mood was better, and I had great shape.

Now I have a little bit afraid because I have symptoms of ulcerative colitis, is three months that I can not go to the gym because of rectal bleeding,and I lost lot of weight,  I made a virtual colonoscopy, Endo anal ultrasound, and is all normal, and I felt that autoimmune diseases may also be due to low testosterone, I believe that in addition to gastrointerologist I return also from my endo.

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ravijaua

Weightlifting and yoga, especially weightlifting helps a lot with sexual dysfunction. I feel sexually arouse for a like an hour or two after weightlifting.

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Zero

Hormone replacement with 17β-estradiol plus dihydrotestosterone restores male sexual behavior in rats treated neonatally with clomipramine.

https://www.ncbi.nlm.nih.gov/pubmed/25449595

 

Male sexual behavior (MSB) in rodents, in both its consummatory and motivational components, is regulated by hormones such as testosterone, 17β-estradiol and 5-α-dihydrotestosterone. In experiments, neonatal treatment with clomipramine (CMI; a serotonin reuptake inhibitor) reproduces some of the signs of depression in adult age, including reduced sexual behavior manifested in a lower percentage of subjects that mount, intromit and ejaculate, although their testosterone levels were not altered. However, the effect of this treatment on estrogen levels and the consequences of hormone substitution using 17β-estradiol and 5-α-dihydrotestosterone on the expression of male sexual behavior are still unknown. Therefore, the objective of the present study was to analyze the effect of neonatal treatment with CMI on plasma testosterone and 17β-estradiol levels, and the role of testosterone, 17β-estradiol and 5-α-dihydrotestosterone in altering the consummatory and motivational components of sexual behavior in male rats. To this end, it analyzed the copulatory parameters and sexual incentive motivation (SIM) of rats treated with CMI under two conditions: basal and post-hormone replacements. Neonatal treatment with CMI did not affect plasma testosterone or 17β-estradiol concentrations, but did decrease both the consummatory component and sexual motivation according to the results of the SIM test. These aspects were recovered after administering 17β-estradiol +5-α-dihydrotestosterone, but not testosterone.

 

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sjv16477

Hi people! I'm a pssd sufferer. I invite you to think about what is the main problem of PSSD: that doctors, researchers, pharmacologists, journalist media and people don't know the existence of PSSD. No one (maybe also a lot of people who suffer of it) knows that SSRI cause a so severe damage. No one exept us. In my opinion stay sitted down on a sofa posting messages on a forum and hoping that someone will find a solution for us will not lead us to anywhere. In my opinion we ahve to do something of actually concrete to change our situation. For this reason, for example, I contacted every single TV broadcast and inquiry tv programs, journal and tv journal in my country telling him about the problem and asking him to talk about it. I contacted magazines and experts and opinionist on antidepressant and psychiatric.
At least I found a scientist that is very interested to study our condition (I don't write his name because his study is not officially approved yet) for first on human looking for any hormone imbalance in the brain and then doing a study on mice looking for any alteration in the brain, but he needs money (50000 euros) than we are looking for to do a foundraising campaigne to raise money, maybe by crowdfunding: this is in my opinion doing something actually usefull for us.  
Then I'm doing a website on pssd with reliable and clear information about our syndrome. 

You can find it at [link deleted] ("foundation", until now, is only an evocative name that mean there's a pool of people that is collaborating togheter for a purpose but in the future we want to do a legally recognized foundation).
On this website I want to launch a foundraising campaign in order to found the research above when it will be approved.
I'm looking for people that want to help me to tranlsate my website in most language as possible in order to offer reliable information about PSSD to physician and people from all over the world. Is there anyone that want to help me doing translation from english to another language? 
 

Edited by scallywag
delete link - pssdfoundation dot jimdo dot com

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Djderek

Just relax man. It's not permanent. . When I had it, everyone had the same tone as you, everyone told me I was screwed for life and it went away. I almost killed myself because of those people.

 

Do you sleep? Enjoy anything? Exercise? Work? Have fun? Can you relax? Feel calm and rested? These are all problems that your most likely suffering from. Right? Learn how to take a deep breath, sit back and smell the roses

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