Kat66 Posted March 2, 2022 Share Posted March 2, 2022 51 minutes ago, canaanstongue01 said: @Kat66 numbness pretty much non stop here. glad to hear you are feeling again I am so sorry and hope things change for you! History of depression and anxiety. Symptoms of PTSD. 1998-1999 Venlafaxine 2006-2007 Prozac.2013-15 Sertraline 50mg. 2015 cross-tapered to citalopram 20mg. 2015-2021 Citalopram 20mg (brief increase to 30mg for 2/3 months in 2019. 01/2021 Dropped from 20mg to 10mg, back up to 20mg til June. 25/6/21 stopped CT. Started 50mg 5htp after a week without citalopram in the hope this would balance out my serotonin levels. After 3 days increased to 100mg 5htp. 11/7/21 Stopped 5htp with the intention of reinstating citalopram at 1mg. 16/7/21 Reinstated cit at 1mg. 2/8/21 Increased dose to 2mg. 28/11/21 10% reduction to 1.8mg. 8/12/21 2mg 6/1/22 1.8mg 10/2/22 1.6mg 13/5/22 1.5mg 4/6/22 1.55mg 4/7/22 1.4mg 4/8/22 1.25mg 1/11/22 1.1mg 3/3/23 1mg 18/4/23 0.9mg 2/6/23 0.8mg 4/10/23 0.7mg 11/11/23 jumped off @0.7mg started on 5htp 200mg -400mg, L-Theanine, and L-tyrosine 200mg. 25/11/23 came off 5-htp, l-tyrosine and l-Theanine. 24/12/23 went on 7.5mg mirtazapine. 27/12/23 stopped mirtazapine & reinstated citalopram @.35mg. 1/1/24 increased to 0.5mg. PTSD diagnosis October 2023. 11/11/23 started EMDR therapy for PTSD. Multiple unsuccessful attempts to taper off citalopram. Vegan, otherwise healthy lifestyle. Other medications; tapering off combined HRT. Other supplements; magnesium glycinate, vegan omega3. Completely OFF caffeine (since July 21). Finding it difficult to completely give up alcohol but haven’t had any since 25/12/23. Main symptoms; crushing depression, anhedonia/emotional anesthesia, irritability, rage, anxiety/fear, intrusive thoughts, cognitive fog, inability to focus, restlessness and some insomnia Link to comment Share on other sites More sharing options...
ThatOneGirlStitch Posted March 3, 2022 Share Posted March 3, 2022 @Kat66 I am very happy for you. Enjoy every bit you can. I know you can truly appreciate it. It is so important that people come back to offer hope. You doing so is wonderful. People make many post about suffering from it, but if they post at all when they are better they only leave one post or so. It can get easily buried under all their previous ones. I think that might add to the fact that you have to dig to find the positive. People are louder when they are hurting. Continue getting better. 2 Current: Bupropion 450mg, Neurontin 800mg, Klonopin 0.5mg History: July 2020: started Cogentin 1mg, Lamictal 50mg, Zoloft 150mg, Zyprexa 5mg (+5mg as needed), Klonopin 0.5mg November 2020: stopped all meds cold-turkey February 2021: started Latuda 60mg, Lithium 300mg, Melatonin 5mg, Protonix 40mg, Topamax 25mg 2 weeks later: stopped Topamax, increased Lithium 900mg, started Klonopin 1mg, Lexapro 20mg, Neurontin 400mg April 2021: started Bupropion 150mg, Revia ?mg May 2021: stopped Revia, Protonix, Lexapro, increased Neurontin 800mg, started Celexa 10mg August 2021: decreased Celexa 5mg (stopped Celexa 2 weeks later), increased Bupropion 300mg September 2021: increased Latuda 80mg October 2021: decreased Lithium 600mg for 4 days, Lithium 300mg for 4 days, stopped Lithium, Latuda, increased Bupropion 450mg, started Remeron 15mg, decreased Remeron 7.5mg, stopped Remeron Link to comment Share on other sites More sharing options...
miomio Posted March 9, 2022 Share Posted March 9, 2022 Over 3 years in ....still unabe to feel positive emotions and unable to feel compassion or able to cry . It really makes me Mad. Started Venlafaxine around 2007-2008 for around 4,5-5 years 70mg ca .2012 Taper as doctors advise 2 weeks skip a day and stop 7 -8 later months total breakdown after sruggling a lot Hospitalized and started on Cipralex. Taper as doctors advise: Mai 2018 from 20 to 10 mg escitalopram to zero in one Month. supplements Magnesium citrate 600 mg Omega 3 2000 mg vitamin D3 sometimes Link to comment Share on other sites More sharing options...
Sofa Posted March 16, 2022 Share Posted March 16, 2022 @Jnthnslo On 2/2/2022 at 3:02 AM, Jnthnslo said: Yes, I've found a few success stories of people coming out or full blown emotional anesthesia. I've slowly been collecting stories as I find them and can work on posting links as well. Specifically, I've found stories of those who once had anxiety and lost it during the anesthesia. They said their emotions all returned, even the anxiety. Most of them also described it as a very slow process where progress was unnoticeable. For me, the most comforting description was that many of them were like us in thinking that they would never recover with that strange head feeling that fells so permanent. Hi, i am struggling with emotional anesthesia! Could you post some success stories that you have found? Or where you found them? 1 June-July -21 Zyprexa 2.5-7.5 mg July -21 Mianserin 20 mg four days July-Aug -21 Valium 30 mg a day, tapred, return of symptoms Aug-Oct -21 Oxazepam Tapred from 10 mg x 3 to zero Dec-Jan -21/22 On and off mirtazapine 15 mg. Kindling reaction? March 8.-19. - Zopiclone 7.5 mg to combat insomnia March 20 - 5 mg valium because of akathisia and panic April 3. - 5 mg x 2 Link to comment Share on other sites More sharing options...
Sofa Posted March 18, 2022 Share Posted March 18, 2022 Is it possible to get emotional anesthesia after quitting antidepressant? Quit mirtazapine beginning of january after taking it on and off. And after 1.5 months there was like i switch went off. Suddenly i had no emotions at all! Complete zombie, feeling dead inside. No libido, no interest in anything or feeling of connection to the world, intense dp/dr, blank mind and cognitive issues Is this normal? I feel scared and so empty inside June-July -21 Zyprexa 2.5-7.5 mg July -21 Mianserin 20 mg four days July-Aug -21 Valium 30 mg a day, tapred, return of symptoms Aug-Oct -21 Oxazepam Tapred from 10 mg x 3 to zero Dec-Jan -21/22 On and off mirtazapine 15 mg. Kindling reaction? March 8.-19. - Zopiclone 7.5 mg to combat insomnia March 20 - 5 mg valium because of akathisia and panic April 3. - 5 mg x 2 Link to comment Share on other sites More sharing options...
canaanstongue01 Posted March 18, 2022 Share Posted March 18, 2022 @Sofa yes, unfortunately. this was my experience as well, gradual creeping anhedonia and then suddenly the switch was flipped. i’m sorry to hear it’s happened to you. here is the PSSD topic -lexapro 10mg daily from 2012 to 2021 (halfed dose in 4/2021, went all the way off 6/21) -various benzos 2014-2019... valium 2019-10/2021~20mg, inconsistent but daily dosing 10/9-17.5mg 10/23-15m 11/29 - 12.5 12/24 - 12 12/31 - 11.5 2/27/22 - 11 3/31 - 10.5 4/14 - 10 5/3 - 9.5 5/15 - 9 6/6 - 8.5 Link to comment Share on other sites More sharing options...
Sofa Posted March 18, 2022 Share Posted March 18, 2022 @canaanstongue01 Is it possible to heal? I seem to be getting worse, and my cognitive abilities are declining rather fast. I have trouble even watching tv and talking on the phone June-July -21 Zyprexa 2.5-7.5 mg July -21 Mianserin 20 mg four days July-Aug -21 Valium 30 mg a day, tapred, return of symptoms Aug-Oct -21 Oxazepam Tapred from 10 mg x 3 to zero Dec-Jan -21/22 On and off mirtazapine 15 mg. Kindling reaction? March 8.-19. - Zopiclone 7.5 mg to combat insomnia March 20 - 5 mg valium because of akathisia and panic April 3. - 5 mg x 2 Link to comment Share on other sites More sharing options...
canaanstongue01 Posted March 18, 2022 Share Posted March 18, 2022 @Sofa i am the same way, i have a very hard time doing anything, feel so disconnected from all of it. i am told that we heal gradually over many months. i am in my 8th month since quitting now and have had the anhedonia and pssd for about 6.5 of those. from october to february it seemed to just get worse all the time. there have been a couple windows in march where i can at least conceptualize what it would look like to heal. one day i was able to laugh. most of the time i feel like i’m serving a prison sentence. i guess my answer to your question is i really hope so. there are success stories where people have recovered or improved in these areas -lexapro 10mg daily from 2012 to 2021 (halfed dose in 4/2021, went all the way off 6/21) -various benzos 2014-2019... valium 2019-10/2021~20mg, inconsistent but daily dosing 10/9-17.5mg 10/23-15m 11/29 - 12.5 12/24 - 12 12/31 - 11.5 2/27/22 - 11 3/31 - 10.5 4/14 - 10 5/3 - 9.5 5/15 - 9 6/6 - 8.5 Link to comment Share on other sites More sharing options...
kostakonkordia Posted March 18, 2022 Share Posted March 18, 2022 4 hours ago, Sofa said: Is it possible to get emotional anesthesia after quitting antidepressant? Quit mirtazapine beginning of january after taking it on and off. And after 1.5 months there was like i switch went off. Suddenly i had no emotions at all! Complete zombie, feeling dead inside. No libido, no interest in anything or feeling of connection to the world, intense dp/dr, blank mind and cognitive issues Is this normal? I feel scared and so empty inside Did anything happen 1,5 months after quitting? A stressfull event or something? Did you take any medication at this time? Ad's since 2016 (I was 16 then...) (Escitalopram) Nov 2018 switch to venlafaxin 150mg Nov 2019 to march 2020 tapered by 37,5mg to cero. (breakdown, minor w/d symptoms for a few days only panic attacks followed by deep depression came a month later duo to stress). Reinstated venla 150mg in Juli 2020. Nov 2020 to April 2021 tapering by 15mg every month or so until I reached approximately 50 mg(no w/d symptoms) Since April 2021 tapered once by 5% and once by 10% of the last dose because I'm not stable enough for w/d. Current dose 50mg venlafaxin No other medication. No supplements Stopped smoking 29.12.2021 No alcohol Link to comment Share on other sites More sharing options...
kostakonkordia Posted March 18, 2022 Share Posted March 18, 2022 1 hour ago, Sofa said: @canaanstongue01 Is it possible to heal? I seem to be getting worse, and my cognitive abilities are declining rather fast. I have trouble even watching tv and talking on the phone Yes of course it's possible to heal. This is most definitely a inflammatory matter located in the gut microbiom. So yes it's totally possible to heal completely. Go to the pssd subreddit. There is the theory about this if you are interested. Ad's since 2016 (I was 16 then...) (Escitalopram) Nov 2018 switch to venlafaxin 150mg Nov 2019 to march 2020 tapered by 37,5mg to cero. (breakdown, minor w/d symptoms for a few days only panic attacks followed by deep depression came a month later duo to stress). Reinstated venla 150mg in Juli 2020. Nov 2020 to April 2021 tapering by 15mg every month or so until I reached approximately 50 mg(no w/d symptoms) Since April 2021 tapered once by 5% and once by 10% of the last dose because I'm not stable enough for w/d. Current dose 50mg venlafaxin No other medication. No supplements Stopped smoking 29.12.2021 No alcohol Link to comment Share on other sites More sharing options...
canaanstongue01 Posted March 18, 2022 Share Posted March 18, 2022 @kostakonkordia for me, the stressful event that seemed to really break everything down was when i started tapering valium in october. i can’t handle the pssd subreddit. -lexapro 10mg daily from 2012 to 2021 (halfed dose in 4/2021, went all the way off 6/21) -various benzos 2014-2019... valium 2019-10/2021~20mg, inconsistent but daily dosing 10/9-17.5mg 10/23-15m 11/29 - 12.5 12/24 - 12 12/31 - 11.5 2/27/22 - 11 3/31 - 10.5 4/14 - 10 5/3 - 9.5 5/15 - 9 6/6 - 8.5 Link to comment Share on other sites More sharing options...
kostakonkordia Posted March 18, 2022 Share Posted March 18, 2022 1 minute ago, canaanstongue01 said: @kostakonkordia for me, the stressful event that seemed to really break everything down was when i started tapering valium in october. i can’t handle the pssd subreddit. Ahhh okok. Why can't you handle the pssd subreddit? Ad's since 2016 (I was 16 then...) (Escitalopram) Nov 2018 switch to venlafaxin 150mg Nov 2019 to march 2020 tapered by 37,5mg to cero. (breakdown, minor w/d symptoms for a few days only panic attacks followed by deep depression came a month later duo to stress). Reinstated venla 150mg in Juli 2020. Nov 2020 to April 2021 tapering by 15mg every month or so until I reached approximately 50 mg(no w/d symptoms) Since April 2021 tapered once by 5% and once by 10% of the last dose because I'm not stable enough for w/d. Current dose 50mg venlafaxin No other medication. No supplements Stopped smoking 29.12.2021 No alcohol Link to comment Share on other sites More sharing options...
canaanstongue01 Posted March 18, 2022 Share Posted March 18, 2022 @kostakonkordia there is a whole lotta doom and gloom and not much hope at all to be found on it, and it just makes me obsess about something that may very well go away on its own. maybe i’ll feel differently about it if i still feel this way after a year. -lexapro 10mg daily from 2012 to 2021 (halfed dose in 4/2021, went all the way off 6/21) -various benzos 2014-2019... valium 2019-10/2021~20mg, inconsistent but daily dosing 10/9-17.5mg 10/23-15m 11/29 - 12.5 12/24 - 12 12/31 - 11.5 2/27/22 - 11 3/31 - 10.5 4/14 - 10 5/3 - 9.5 5/15 - 9 6/6 - 8.5 Link to comment Share on other sites More sharing options...
canaanstongue01 Posted March 19, 2022 Share Posted March 19, 2022 aa question for mods: am i correct in my understanding that reinstatement doesn’t really address this particular set of symptoms? -lexapro 10mg daily from 2012 to 2021 (halfed dose in 4/2021, went all the way off 6/21) -various benzos 2014-2019... valium 2019-10/2021~20mg, inconsistent but daily dosing 10/9-17.5mg 10/23-15m 11/29 - 12.5 12/24 - 12 12/31 - 11.5 2/27/22 - 11 3/31 - 10.5 4/14 - 10 5/3 - 9.5 5/15 - 9 6/6 - 8.5 Link to comment Share on other sites More sharing options...
Landis Posted March 20, 2022 Share Posted March 20, 2022 On 3/18/2022 at 6:08 PM, kostakonkordia said: Yes of course it's possible to heal. This is most definitely a inflammatory matter located in the gut microbiom. So yes it's totally possible to heal completely. Go to the pssd subreddit. There is the theory about this if you are interested. Hi, kostakonkordia! I am very interested in your message about the close correlation of anhedonia with inflammatory processes in the gut microbiota: the fact is that since the end of 2016 I have been suffering from ulcerative colitis, but this disease has been extremely mild for me, for more than five years there have been no relapses visited me. Unfortunately, for more than four months I have been suffering from unbearable anhedonia, which visited me three days after the abrupt withdrawal of olanzapine: I am now curious if the abrupt termination of olanzapine could have such a negative effect on me due to ulcerative colitis? Perhaps this is a flimsy hypothesis, but I still feel some heuristic potential in it. Oct 20 2021 - Nov 11 2021: 2.5 mg (1.25 mg. in the morning and 1.25 mg. in the evening) -- abruptly stopped taking the drug (cold turkey)Nov 15 2021: an attempt to reinstate olanzapine (I don’t remember the exact dosage, but it was 1.25 or 2.5 mg.), failed due to my fear of this drugNov 16 2021: took 25 mg. quetiapine at nightNov 17 2021 - Nov 18 2021: took olanzapine at a dosage of 1.25 mg for two days in a row, stopped the drug againNov 20 2021 - Nov 29 2021: chaotically took quetiapine these days (I think I took 25 mg one night and 12.5 mg the other) and olanzapine (also a couple of times 1.25 mg each, and the last dose fell on November 29th)Dec 2021 - Jan 2021: for a month and a half to two months I took many different natural supplements (fish oil, 5-HTP, St. John's wort, green tea extract, tyrosine, biotin, citicoline, Alpha GPC) and multivitamin complexes (B vitamins, for example); in addition, in the same weeks I took about 8-10 tablets of phenazepam, but I never did this even for two days in a row, because I just needed to relieve my anxiety, even if temporarily; from time to time I also took hydroxyzine during these months with an approximate regularity equal to one tablet (dosage - 0.25 mg.) in 5-6 days; in the first 14 days of January, I was also injected intramuscularly with peptides (cortexin)beginning of February 2022: four days in a row I used 37.5 mg. venlafaxine, 25 mg. lamotrigine and 50 mg. trazodone (soon gave up all drugs due to lack of visible effects)end of February 2022: I once tried a 50mg sulpiride capsule and a few days later took a 250mg Phenibut tablet (again, no noticeable effects) Link to comment Share on other sites More sharing options...
Landis Posted March 20, 2022 Share Posted March 20, 2022 48 minutes ago, canaanstongue01 said: aa question for mods: am i correct in my understanding that reinstatement doesn’t really address this particular set of symptoms? Double this question. I have only a very rough idea of the pathogenesis of anhedonia induced by antidepressants, but in the case of high-potency antipsychotics everything looks a little more prosaic and transparent: the same olanzapine, after the withdrawal of which anhedonia debuted in me, thoroughly antagonizes all five subtypes of dopamine receptors, so its anhedogenic mechanisms are more or less tangible. On the other hand, no anhedonia followed me during all three weeks of taking olanzapine, it manifested itself only three days after the abrupt withdrawal of the drug. How to explain it? The brain could not return to the pre-drug state on its own, stalled and launched emergency compensatory mechanisms, as a result of which my nucleus accumbens was damaged? I would very much like to be wrong, as this is a fatal assumption... Oct 20 2021 - Nov 11 2021: 2.5 mg (1.25 mg. in the morning and 1.25 mg. in the evening) -- abruptly stopped taking the drug (cold turkey)Nov 15 2021: an attempt to reinstate olanzapine (I don’t remember the exact dosage, but it was 1.25 or 2.5 mg.), failed due to my fear of this drugNov 16 2021: took 25 mg. quetiapine at nightNov 17 2021 - Nov 18 2021: took olanzapine at a dosage of 1.25 mg for two days in a row, stopped the drug againNov 20 2021 - Nov 29 2021: chaotically took quetiapine these days (I think I took 25 mg one night and 12.5 mg the other) and olanzapine (also a couple of times 1.25 mg each, and the last dose fell on November 29th)Dec 2021 - Jan 2021: for a month and a half to two months I took many different natural supplements (fish oil, 5-HTP, St. John's wort, green tea extract, tyrosine, biotin, citicoline, Alpha GPC) and multivitamin complexes (B vitamins, for example); in addition, in the same weeks I took about 8-10 tablets of phenazepam, but I never did this even for two days in a row, because I just needed to relieve my anxiety, even if temporarily; from time to time I also took hydroxyzine during these months with an approximate regularity equal to one tablet (dosage - 0.25 mg.) in 5-6 days; in the first 14 days of January, I was also injected intramuscularly with peptides (cortexin)beginning of February 2022: four days in a row I used 37.5 mg. venlafaxine, 25 mg. lamotrigine and 50 mg. trazodone (soon gave up all drugs due to lack of visible effects)end of February 2022: I once tried a 50mg sulpiride capsule and a few days later took a 250mg Phenibut tablet (again, no noticeable effects) Link to comment Share on other sites More sharing options...
Sofa Posted March 20, 2022 Share Posted March 20, 2022 Is it possible to lose emotions completely? My brain seem to interpret more and more things as just neutral, and nothing works to calm me down anymore because nothing brings comfort and calmness. This is really hard with the akathisa on top. The new thing is no reaction or memory to smell. I first thought i had corona again, but no. My brain does not make a connection to smell. Is this normal? I dont want to eat or drink anymore. I also cant cry some days. This comes and goes. I have this pressure in my head that seems to inhibit it. Bur when i do cry, i still dont «feel» it in the rest of my body, the sadness. Is it normal for it to get worse at two months off? Will this get better someday? June-July -21 Zyprexa 2.5-7.5 mg July -21 Mianserin 20 mg four days July-Aug -21 Valium 30 mg a day, tapred, return of symptoms Aug-Oct -21 Oxazepam Tapred from 10 mg x 3 to zero Dec-Jan -21/22 On and off mirtazapine 15 mg. Kindling reaction? March 8.-19. - Zopiclone 7.5 mg to combat insomnia March 20 - 5 mg valium because of akathisia and panic April 3. - 5 mg x 2 Link to comment Share on other sites More sharing options...
Sofa Posted March 20, 2022 Share Posted March 20, 2022 Since it keeps getting worse, would reinstatement be an option? I just dont understand why it gets worse? I dont want to lose more of myself June-July -21 Zyprexa 2.5-7.5 mg July -21 Mianserin 20 mg four days July-Aug -21 Valium 30 mg a day, tapred, return of symptoms Aug-Oct -21 Oxazepam Tapred from 10 mg x 3 to zero Dec-Jan -21/22 On and off mirtazapine 15 mg. Kindling reaction? March 8.-19. - Zopiclone 7.5 mg to combat insomnia March 20 - 5 mg valium because of akathisia and panic April 3. - 5 mg x 2 Link to comment Share on other sites More sharing options...
Jnthnslo Posted March 20, 2022 Share Posted March 20, 2022 @Sofa I can only speak from my experience personally but I too slowly got worse around the 2 to 3 month period. There were days where I couldn’t feel any emotions at all. Completely blank for weeks. I thought I’d continue to get worse and worse but I’ve started to have days where Ive had hints of my emotions back. Some days are better than others but I do have days where I’m happy. Don’t give up there is hope. 2 Pristiq 25 mg - Oct 9 2021 Pristiq 25 mg - Oct 8 2021 Pristiq 25 mg - Oct 7 2021 Pristiq 25 mg - Oct 6 2021 Link to comment Share on other sites More sharing options...
Sofa Posted March 21, 2022 Share Posted March 21, 2022 @Jnthnslo Thank you so much! I really needed the hope! My akathisia was so bad yesterday, and with nothing being able to make me «feel» calm, i caved and had to take a Valium. Hope i did not screw up recovery too much. Wahts weird is tha the valium lifted some of the head pressure and extreme cog fog for a little while. June-July -21 Zyprexa 2.5-7.5 mg July -21 Mianserin 20 mg four days July-Aug -21 Valium 30 mg a day, tapred, return of symptoms Aug-Oct -21 Oxazepam Tapred from 10 mg x 3 to zero Dec-Jan -21/22 On and off mirtazapine 15 mg. Kindling reaction? March 8.-19. - Zopiclone 7.5 mg to combat insomnia March 20 - 5 mg valium because of akathisia and panic April 3. - 5 mg x 2 Link to comment Share on other sites More sharing options...
kostakonkordia Posted March 21, 2022 Share Posted March 21, 2022 On 3/20/2022 at 1:06 AM, Landis said: Hi, kostakonkordia! I am very interested in your message about the close correlation of anhedonia with inflammatory processes in the gut microbiota: the fact is that since the end of 2016 I have been suffering from ulcerative colitis, but this disease has been extremely mild for me, for more than five years there have been no relapses visited me. Unfortunately, for more than four months I have been suffering from unbearable anhedonia, which visited me three days after the abrupt withdrawal of olanzapine: I am now curious if the abrupt termination of olanzapine could have such a negative effect on me due to ulcerative colitis? Perhaps this is a flimsy hypothesis, but I still feel some heuristic potential in it. Anhedonia and protracted withdrawal is a inflammatory issue. I say this with great emphasis and I don't care if the mods don't like it that I write about this so much. People have to understand that this is not some kind of brain damage or receptor issue. Even the worst heroin addicts are stable after a few weeks. I could explain this to you but it's best you look at my recent posts or you go on the pssd subreddit and read the theories from lastround360. Ad's since 2016 (I was 16 then...) (Escitalopram) Nov 2018 switch to venlafaxin 150mg Nov 2019 to march 2020 tapered by 37,5mg to cero. (breakdown, minor w/d symptoms for a few days only panic attacks followed by deep depression came a month later duo to stress). Reinstated venla 150mg in Juli 2020. Nov 2020 to April 2021 tapering by 15mg every month or so until I reached approximately 50 mg(no w/d symptoms) Since April 2021 tapered once by 5% and once by 10% of the last dose because I'm not stable enough for w/d. Current dose 50mg venlafaxin No other medication. No supplements Stopped smoking 29.12.2021 No alcohol Link to comment Share on other sites More sharing options...
kostakonkordia Posted March 21, 2022 Share Posted March 21, 2022 On 3/20/2022 at 1:06 AM, Landis said: Hi, kostakonkordia! I am very interested in your message about the close correlation of anhedonia with inflammatory processes in the gut microbiota: the fact is that since the end of 2016 I have been suffering from ulcerative colitis, but this disease has been extremely mild for me, for more than five years there have been no relapses visited me. Unfortunately, for more than four months I have been suffering from unbearable anhedonia, which visited me three days after the abrupt withdrawal of olanzapine: I am now curious if the abrupt termination of olanzapine could have such a negative effect on me due to ulcerative colitis? Perhaps this is a flimsy hypothesis, but I still feel some heuristic potential in it. If you had ulceritis before this you should look into Andy cutlers heavy metal chelation. Mercury is one of th most toxic non radioactive metals and they can produce all sorts of issues. Do you have amalgam fillings? Ad's since 2016 (I was 16 then...) (Escitalopram) Nov 2018 switch to venlafaxin 150mg Nov 2019 to march 2020 tapered by 37,5mg to cero. (breakdown, minor w/d symptoms for a few days only panic attacks followed by deep depression came a month later duo to stress). Reinstated venla 150mg in Juli 2020. Nov 2020 to April 2021 tapering by 15mg every month or so until I reached approximately 50 mg(no w/d symptoms) Since April 2021 tapered once by 5% and once by 10% of the last dose because I'm not stable enough for w/d. Current dose 50mg venlafaxin No other medication. No supplements Stopped smoking 29.12.2021 No alcohol Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted March 21, 2022 Administrator Share Posted March 21, 2022 There is zero evidence that anhedonia and protracted withdrawal is a inflammatory issue, @kostakonkordia You may hold to your beliefs, but we would rather have good information on this site rather than wild theories. People are also welcome to participate on reddit for their withdrawal support, just don't bring back reddit nonsense here. 1 This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
kostakonkordia Posted March 21, 2022 Share Posted March 21, 2022 (edited) 39 minutes ago, Altostrata said: There is zero evidence that anhedonia and protracted withdrawal is a inflammatory issue, @kostakonkordia You may hold to your beliefs, but we would rather have good information on this site rather than wild theories. People are also welcome to participate on reddit for their withdrawal support, just don't bring back reddit nonsense here. Has anyone actually made the efford to look into it?? On the pssd subreddit 15 people got tested for dysbiosis and 15 people got a positive result... On the pfs forums people regularly test for ridiculous high autoantibodys and some of the pssd sufferers have been tested too. Also someone from the anhedonia subreddit was tested positive for dopamine receptor autoantibodys. As I said many times the symptoms of alot of autoimmune disease mirror those of protracted withdrawal. To me after thinking about this many times and evaluating everything it's the only logical conclusion I came to... Then whats science saying about protracted withdrawal or pssd? What's their explanation?? They have none. Healy hasn't found anything yet. Also they lack of systematic thinking like most scientists do. And pssd and protracted withdrawal is actually the same. Alot of people with pssd have the same symptoms as the protracted ones... Like akathisia brain fog etc. Lastround was cured by a round of antibiotics, a guy names blauwasser was cured by fmts and there are countless others who have cured themselves with "random" supplements which, who would belive it almost all influence the gut or the immunesystem or liver enzymes. You decide for yourself what you want to do with this knowledge... But more people should look into this if you ask me, alot could benefit from if it is true. Edited March 21, 2022 by kostakonkordia Ad's since 2016 (I was 16 then...) (Escitalopram) Nov 2018 switch to venlafaxin 150mg Nov 2019 to march 2020 tapered by 37,5mg to cero. (breakdown, minor w/d symptoms for a few days only panic attacks followed by deep depression came a month later duo to stress). Reinstated venla 150mg in Juli 2020. Nov 2020 to April 2021 tapering by 15mg every month or so until I reached approximately 50 mg(no w/d symptoms) Since April 2021 tapered once by 5% and once by 10% of the last dose because I'm not stable enough for w/d. Current dose 50mg venlafaxin No other medication. No supplements Stopped smoking 29.12.2021 No alcohol Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted March 21, 2022 Administrator Share Posted March 21, 2022 I'm going to have to ask you to stop posting rumors from reddit, @kostakonkordia 1 This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
Landis Posted March 22, 2022 Share Posted March 22, 2022 3 hours ago, kostakonkordia said: Anhedonia and protracted withdrawal is a inflammatory issue. I say this with great emphasis and I don't care if the mods don't like it that I write about this so much. People have to understand that this is not some kind of brain damage or receptor issue. Even the worst heroin addicts are stable after a few weeks. I could explain this to you but it's best you look at my recent posts or you go on the pssd subreddit and read the theories from lastround360. I understand that you are perceived here as an armchair scientist who calls to accept on faith theories that look like deliberately heretical in the local conceptual discourse, but for some reason it seems to me that there is some rational grain in your assumptions, which we cannot yet carefully cut into theoretically, since we still lack an empirical big data and a consistent categorical apparatus for unproblematic validation of your curious conclusions. I will definitely get acquainted with the ideological heritage of the redditor you mentioned, I hope that his explanatory model will give me rich food for thought and will not turn out to be rigorously doctrinal, I like to learn something new! Oct 20 2021 - Nov 11 2021: 2.5 mg (1.25 mg. in the morning and 1.25 mg. in the evening) -- abruptly stopped taking the drug (cold turkey)Nov 15 2021: an attempt to reinstate olanzapine (I don’t remember the exact dosage, but it was 1.25 or 2.5 mg.), failed due to my fear of this drugNov 16 2021: took 25 mg. quetiapine at nightNov 17 2021 - Nov 18 2021: took olanzapine at a dosage of 1.25 mg for two days in a row, stopped the drug againNov 20 2021 - Nov 29 2021: chaotically took quetiapine these days (I think I took 25 mg one night and 12.5 mg the other) and olanzapine (also a couple of times 1.25 mg each, and the last dose fell on November 29th)Dec 2021 - Jan 2021: for a month and a half to two months I took many different natural supplements (fish oil, 5-HTP, St. John's wort, green tea extract, tyrosine, biotin, citicoline, Alpha GPC) and multivitamin complexes (B vitamins, for example); in addition, in the same weeks I took about 8-10 tablets of phenazepam, but I never did this even for two days in a row, because I just needed to relieve my anxiety, even if temporarily; from time to time I also took hydroxyzine during these months with an approximate regularity equal to one tablet (dosage - 0.25 mg.) in 5-6 days; in the first 14 days of January, I was also injected intramuscularly with peptides (cortexin)beginning of February 2022: four days in a row I used 37.5 mg. venlafaxine, 25 mg. lamotrigine and 50 mg. trazodone (soon gave up all drugs due to lack of visible effects)end of February 2022: I once tried a 50mg sulpiride capsule and a few days later took a 250mg Phenibut tablet (again, no noticeable effects) Link to comment Share on other sites More sharing options...
Landis Posted March 22, 2022 Share Posted March 22, 2022 3 hours ago, kostakonkordia said: If you had ulceritis before this you should look into Andy cutlers heavy metal chelation. Mercury is one of th most toxic non radioactive metals and they can produce all sorts of issues. Do you have amalgam fillings? If my memory serves me right, then there really are amalgam fillings in my oral cavity, and they have been there for more than a year... I have never heard of Andy Cutler's treatment protocol, but it sounds entertaining, I did not even suspect the existence of such a cognitive perspective and interpretive strategy. Unusual point of view, thanks for the enlightenment! Oct 20 2021 - Nov 11 2021: 2.5 mg (1.25 mg. in the morning and 1.25 mg. in the evening) -- abruptly stopped taking the drug (cold turkey)Nov 15 2021: an attempt to reinstate olanzapine (I don’t remember the exact dosage, but it was 1.25 or 2.5 mg.), failed due to my fear of this drugNov 16 2021: took 25 mg. quetiapine at nightNov 17 2021 - Nov 18 2021: took olanzapine at a dosage of 1.25 mg for two days in a row, stopped the drug againNov 20 2021 - Nov 29 2021: chaotically took quetiapine these days (I think I took 25 mg one night and 12.5 mg the other) and olanzapine (also a couple of times 1.25 mg each, and the last dose fell on November 29th)Dec 2021 - Jan 2021: for a month and a half to two months I took many different natural supplements (fish oil, 5-HTP, St. John's wort, green tea extract, tyrosine, biotin, citicoline, Alpha GPC) and multivitamin complexes (B vitamins, for example); in addition, in the same weeks I took about 8-10 tablets of phenazepam, but I never did this even for two days in a row, because I just needed to relieve my anxiety, even if temporarily; from time to time I also took hydroxyzine during these months with an approximate regularity equal to one tablet (dosage - 0.25 mg.) in 5-6 days; in the first 14 days of January, I was also injected intramuscularly with peptides (cortexin)beginning of February 2022: four days in a row I used 37.5 mg. venlafaxine, 25 mg. lamotrigine and 50 mg. trazodone (soon gave up all drugs due to lack of visible effects)end of February 2022: I once tried a 50mg sulpiride capsule and a few days later took a 250mg Phenibut tablet (again, no noticeable effects) Link to comment Share on other sites More sharing options...
Administrator Altostrata Posted March 22, 2022 Administrator Share Posted March 22, 2022 There is no rational grain in the assumption that inflammation causes anhedonia and protracted withdrawal. It is a fantasy. You may have a idea, but that does not mean it is found in reality. I am going to have to ask this line of discussion cease. One Reddit in the world is enough, we don't have to provide a platform here for uninformed speculation and hot air as well. From now on, further pursuit of this line of discussion will earn warning points. If you get 4 warning points, you will be banned. 1 This is not medical advice. Discuss any decisions about your medical care with a knowledgeable medical practitioner. "It has become appallingly obvious that our technology has surpassed our humanity." -- Albert Einstein All postings © copyrighted. Link to comment Share on other sites More sharing options...
julesb Posted March 22, 2022 Share Posted March 22, 2022 great info @kostakonkordia zoloft 50-100 mg 2012-2020 Reinstated zoloft 50mg for 2 months 2021 and switched back to Lexapro 10mg Reinstated 10mg 2021 later that year July-september 2021 Reinstated after 4 week withdrawal for 4 days plus lamictal 5mg october 16th Wellbutrin 100mg for 2 days November 2021 Currently on nothing Link to comment Share on other sites More sharing options...
Moderator Frogie Posted March 22, 2022 Moderator Share Posted March 22, 2022 @julesb Please read what @Altostrata just posted above. Thank you. PREVIOUS medications and discontinuations: Have been on medications since 1996. Valium, Gabapentin, Lamictal, Prilosec and Zantac from 2000 to 2015 with a fast taper by a psychiatrist. Liquid Lexapro Nov, 2016 to 31-March, 2019 Lexapro free!!! (total Lexapro taper was 4 years-started with pill form) ---CURRENT MEDICATIONS:Supplements:Milk Thistle, Metamucil, Magnesium Citrate, Vitamin D3, Levothyroxine 25mcg, Vitamin C, Krill oil. Xanax 1mg 3x day June, 2000 to 19-September, 2020 Went from .150 grams (average weight of 1 Xanax) 3x day to .003 grams 3x day. April 1, 2021 went back on 1mg a day. Started tapering May 19, 2023. July 28, 2023-approximately .87mg. Dr. fast tapered me at the end and realized he messed up. Prescribe it again and I am doing "slower than a turtle" taper. 19-September, 2020 Xanax free!!! (total Xanax taper was 15-1/2 months-1-June, 2019-19-September, 2020) I am not a medical professional. The suggestions I make are based on personal experience. Link to comment Share on other sites More sharing options...
canaanstongue01 Posted March 22, 2022 Share Posted March 22, 2022 aa question for mods: am i correct in my understanding that reinstatement doesn’t really address this particular set of symptoms? i’m still just wondering about this… -lexapro 10mg daily from 2012 to 2021 (halfed dose in 4/2021, went all the way off 6/21) -various benzos 2014-2019... valium 2019-10/2021~20mg, inconsistent but daily dosing 10/9-17.5mg 10/23-15m 11/29 - 12.5 12/24 - 12 12/31 - 11.5 2/27/22 - 11 3/31 - 10.5 4/14 - 10 5/3 - 9.5 5/15 - 9 6/6 - 8.5 Link to comment Share on other sites More sharing options...
ThatOneGirlStitch Posted March 23, 2022 Share Posted March 23, 2022 On 2/1/2022 at 8:02 PM, Jnthnslo said: @ManatiYes, I've found a few success stories of people coming out or full blown emotional anesthesia. I've slowly been collecting stories as I find them and can work on posting links as well. Specifically, I've found stories of those who once had anxiety and lost it during the anesthesia. They said their emotions all returned, even the anxiety. Most of them also described it as a very slow process where progress was unnoticeable. For me, the most comforting description was that many of them were like us in thinking that they would never recover with that strange head feeling that fells so permanent. Out of curiosity did any of them get anhedonia in a matter of day to days? I was just wondering if you know. Current: Bupropion 450mg, Neurontin 800mg, Klonopin 0.5mg History: July 2020: started Cogentin 1mg, Lamictal 50mg, Zoloft 150mg, Zyprexa 5mg (+5mg as needed), Klonopin 0.5mg November 2020: stopped all meds cold-turkey February 2021: started Latuda 60mg, Lithium 300mg, Melatonin 5mg, Protonix 40mg, Topamax 25mg 2 weeks later: stopped Topamax, increased Lithium 900mg, started Klonopin 1mg, Lexapro 20mg, Neurontin 400mg April 2021: started Bupropion 150mg, Revia ?mg May 2021: stopped Revia, Protonix, Lexapro, increased Neurontin 800mg, started Celexa 10mg August 2021: decreased Celexa 5mg (stopped Celexa 2 weeks later), increased Bupropion 300mg September 2021: increased Latuda 80mg October 2021: decreased Lithium 600mg for 4 days, Lithium 300mg for 4 days, stopped Lithium, Latuda, increased Bupropion 450mg, started Remeron 15mg, decreased Remeron 7.5mg, stopped Remeron Link to comment Share on other sites More sharing options...
ThatOneGirlStitch Posted March 23, 2022 Share Posted March 23, 2022 On 3/20/2022 at 3:04 AM, Sofa said: Is it possible to lose emotions completely? My brain seem to interpret more and more things as just neutral, and nothing works to calm me down anymore because nothing brings comfort and calmness. This is really hard with the akathisa on top. The new thing is no reaction or memory to smell. I first thought i had corona again, but no. My brain does not make a connection to smell. Is this normal? I dont want to eat or drink anymore. I also cant cry some days. This comes and goes. I have this pressure in my head that seems to inhibit it. Bur when i do cry, i still dont «feel» it in the rest of my body, the sadness. Is it normal for it to get worse at two months off? Will this get better someday? @Sofa I am the same. Not being able to calm myself is upsetting. Smell triggers emotional feelings. I smell too well now, it is awful, but I do not get feelings from it. I am no longer hungry or thirsty. I also know of the head pressure. Yes it can get better. It is not uncommon for anhedonia to show up after getting off. Sometimes it's so snail slow that you do not notice it changing. Sometimes after a long time it goes away within weeks or days. Also at @canaanstongue01 I am not a mod, but I have not heard reinstatement fixing anhedonia/pssd reliably. I have only heard of one story which it fixed someones pssd. And they didn't just reinstate, they had a pattern and process they were following. I am guessing this was an unlikely out come since I have not heard any of his many followers (it was quite the story at the time) being helped by it. I know one guy who personally tried reinstatement for anhedonia. He said he felt like the feelings where coming back, small things; relief after going to the bathroom, pssd lifting slightly. But it did not last more than a few days. Really I can not say with certainty whether it would or would not work, this is just what I have found lurking on various forums. I am just guessing but reinstatement might have a better change with physical symptoms or anxiety. I myself am skeptical about it helping with anhedonia, I think I would see more people reinstating and reporting back. But drugs can give people anhedonia in different ways. Coming suddenly, slowly, in waves, or most common from what I see, constant. I do not know why this is, but we can certainly make guesses. When I get upset it can spiral down quick. I can not calm myself and must wait it out and try not to think. You can try holding a stuffed animal and wrapping yourself in a blanket, put on a stupid cartoon and try to focus on that to keep your mind from thinking. These thing don't bring comfort but it is a go-to if it happens. Keep focused on something even if you don't care about it. Have an audiobook ready. I listen to peter rabbit or the tale of the frog prince and try to let the words drowned out my thoughts. Just wondering, what do you do when you get upset? Do you have a routine on a go to? Do you have to wait also? 1 Current: Bupropion 450mg, Neurontin 800mg, Klonopin 0.5mg History: July 2020: started Cogentin 1mg, Lamictal 50mg, Zoloft 150mg, Zyprexa 5mg (+5mg as needed), Klonopin 0.5mg November 2020: stopped all meds cold-turkey February 2021: started Latuda 60mg, Lithium 300mg, Melatonin 5mg, Protonix 40mg, Topamax 25mg 2 weeks later: stopped Topamax, increased Lithium 900mg, started Klonopin 1mg, Lexapro 20mg, Neurontin 400mg April 2021: started Bupropion 150mg, Revia ?mg May 2021: stopped Revia, Protonix, Lexapro, increased Neurontin 800mg, started Celexa 10mg August 2021: decreased Celexa 5mg (stopped Celexa 2 weeks later), increased Bupropion 300mg September 2021: increased Latuda 80mg October 2021: decreased Lithium 600mg for 4 days, Lithium 300mg for 4 days, stopped Lithium, Latuda, increased Bupropion 450mg, started Remeron 15mg, decreased Remeron 7.5mg, stopped Remeron Link to comment Share on other sites More sharing options...
ThatOneGirlStitch Posted March 23, 2022 Share Posted March 23, 2022 Below is what I try to do for me or what I have heard others doing, sometime I succeed other times I just can't manage. but I strive for it. In the mean time, routine is important. Get out of bed and get dressed. Dress how you want to feel. Have times in which you sit down and eat. You must eat for your brain to get better. It sucks and its hard, but have times at which you eat. And try to sip at water through out the day. Having a water bottle near you will help. If weather permitted go for a walk, in nature if you can. I have done this, nothing to report, but it is a change of scenery and will help the body. I have been told that is what others who had anhedonia have done. For me: Conversations are hard but sometimes I can get into debates,( should animals have personhood)m it gives the conversation a purpose instead of pointless chat. Phone games may or may not help you but if you find the right ones it can give you instant gratification. You wont feel it but it can keep you occupied. Practice good grooming if I can. Sometimes it is too much effort to move. Practice moving, getting up to eat more. I got a birdfeeder, not much but it gives you movement to watch. I can not relate to characters in books, so I read fairytales from around the world. They are focused on what happens rather than focusing on characters. Reading historical books can be better as well. When feeling the need to cry watch something sad, it may or may not help you. Crying is still good. Eat well, drink well, sleep well, and nature. This is what I have been told from others as this is what they believed helped them. The other thing I heard was keep moving and doing stuff. I purpose is to help your brain. Sorry if this was too much information. I tend to post in bulk. I want to know if others have found ways to manage or if they have heard the same things I have 3 Current: Bupropion 450mg, Neurontin 800mg, Klonopin 0.5mg History: July 2020: started Cogentin 1mg, Lamictal 50mg, Zoloft 150mg, Zyprexa 5mg (+5mg as needed), Klonopin 0.5mg November 2020: stopped all meds cold-turkey February 2021: started Latuda 60mg, Lithium 300mg, Melatonin 5mg, Protonix 40mg, Topamax 25mg 2 weeks later: stopped Topamax, increased Lithium 900mg, started Klonopin 1mg, Lexapro 20mg, Neurontin 400mg April 2021: started Bupropion 150mg, Revia ?mg May 2021: stopped Revia, Protonix, Lexapro, increased Neurontin 800mg, started Celexa 10mg August 2021: decreased Celexa 5mg (stopped Celexa 2 weeks later), increased Bupropion 300mg September 2021: increased Latuda 80mg October 2021: decreased Lithium 600mg for 4 days, Lithium 300mg for 4 days, stopped Lithium, Latuda, increased Bupropion 450mg, started Remeron 15mg, decreased Remeron 7.5mg, stopped Remeron Link to comment Share on other sites More sharing options...
Sofa Posted March 25, 2022 Share Posted March 25, 2022 @ThatOneGirlStitch Thank you for many great tips! My akathisia really makes it hard to relax and causes a lot of anxiety. I also have serious perception and concentration issues because of akathisia and dp/dr. Reading is impossible. Cant understand the words or concentrate. Same with tv and audio. I hear and see, but my brain is not processing it right it feels like, so its hard to get into it. Distraction has become a job on its own. Really exhausting. Dont know what i did to get this unlucky. June-July -21 Zyprexa 2.5-7.5 mg July -21 Mianserin 20 mg four days July-Aug -21 Valium 30 mg a day, tapred, return of symptoms Aug-Oct -21 Oxazepam Tapred from 10 mg x 3 to zero Dec-Jan -21/22 On and off mirtazapine 15 mg. Kindling reaction? March 8.-19. - Zopiclone 7.5 mg to combat insomnia March 20 - 5 mg valium because of akathisia and panic April 3. - 5 mg x 2 Link to comment Share on other sites More sharing options...
ThatOneGirlStitch Posted March 25, 2022 Share Posted March 25, 2022 12 hours ago, Sofa said: @ThatOneGirlStitch Thank you for many great tips! My akathisia really makes it hard to relax and causes a lot of anxiety. I also have serious perception and concentration issues because of akathisia and dp/dr. Reading is impossible. Cant understand the words or concentrate. Same with tv and audio. I hear and see, but my brain is not processing it right it feels like, so its hard to get into it. Distraction has become a job on its own. Really exhausting. Dont know what i did to get this unlucky. I am sorry. distraction is hard for many of use and does feel like we have to put most our energy to it. But it seems like it is a full job for you. I feel like I pissed of some cosmic force. If I remember correctly it feels like the sound is stuck in the back of your head as well. I came across something. It does not seem to fit you exactly but maybe it is some kind of APD. As this is the anhedonia forum, I will post it the hearing forum. Current: Bupropion 450mg, Neurontin 800mg, Klonopin 0.5mg History: July 2020: started Cogentin 1mg, Lamictal 50mg, Zoloft 150mg, Zyprexa 5mg (+5mg as needed), Klonopin 0.5mg November 2020: stopped all meds cold-turkey February 2021: started Latuda 60mg, Lithium 300mg, Melatonin 5mg, Protonix 40mg, Topamax 25mg 2 weeks later: stopped Topamax, increased Lithium 900mg, started Klonopin 1mg, Lexapro 20mg, Neurontin 400mg April 2021: started Bupropion 150mg, Revia ?mg May 2021: stopped Revia, Protonix, Lexapro, increased Neurontin 800mg, started Celexa 10mg August 2021: decreased Celexa 5mg (stopped Celexa 2 weeks later), increased Bupropion 300mg September 2021: increased Latuda 80mg October 2021: decreased Lithium 600mg for 4 days, Lithium 300mg for 4 days, stopped Lithium, Latuda, increased Bupropion 450mg, started Remeron 15mg, decreased Remeron 7.5mg, stopped Remeron Link to comment Share on other sites More sharing options...
Recommended Posts